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A summary of current and novel biomarkers and their potential stages of release in cardiogenicshock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenicshock: progression from cardiac dysfunction/stress, through to inflammation and end-organ dysfunction.
Organ perfusion pressure as a predictor of outcomes in cardiogenicshock: insights from the Altshock-2 registry. ABSTRACT Aims The diagnosis of cardiogenicshock (CS) relies upon signs and/or symptoms of end-organ hypoperfusion. The primary outcome was in-hospital all-cause mortality.
Implantation of an intra-aortic balloon pump (IABP) did not improve 60-day survival or bridge to heart replacement (HRT) therapies in patients with heart failure-cardiogenicshock (HF-CS) compared to standard care, according to a study presented during a Featured Clinical Research session at ACC.25
Cardiogenicshock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%.
Background Cardiogenicshock (CS) induced by severe aortic stenosis (AS) is a life-threatening condition with high mortality. Despite advancements in emergency interventions, the optimal treatment approach remains uncertain.
BackgroundPatients with severe mitral regurgitation and cardiogenicshock demonstrate a poor prognosis. The primary outcome was device success and allcause death, while secondary outcomes included myocardial infarction, stroke, and heart failure hospitalization rates at 30day and intermediateterm followup.
Henry Ford Health's National CardiogenicShock Initiative research team. Cardiogenicshock is a critical condition in which the heart is unable to pump enough blood to sustain the body’s needs, depriving vital organs of blood supply. This can cause those organs to eventually stop functioning.
Background Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenicshock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes.
Windtree Therapeutics’ istaroxime appears to have scored in its latest Phase 2b trial , showing that the steroidal drug significantly improves systolic blood pressure in cardiogenicshock patients. That could be a big deal in the cardiogenicshock space, which many believe is still in need of more effective treatments.
Cardiogenicshock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. Age is a nonmodifiable risk factor for mortality in patients with cardiogenicshock and is often considered in the decision-making process for eligibility for various therapies.
Publication date: Available online 24 January 2025 Source: The American Journal of Cardiology Author(s): Eric J. Hall, Colby R. Ayers, Nicholas S. Hendren, Christopher Clark, Amit Saha, Hadi Beaini, Isabella L. Alexander, Evan P. Gee, Ian R. McConnell, Emily S. Samson, Roslyn J. Saplicki, Christopher S. Grubb, Grant Tucker, Justin L.
Publication date: Available online 14 November 2024 Source: The American Journal of Cardiology Author(s): Pedro Arturo Villablanca, Raef Ali Fadel, Gennaro Giustino, Ahmad Jabri, Mir Babar Basir, Jennifer Cowger, Khaldoon Alaswad, Brian O'Neill, Pedro Engel Gonzalez, Gillian Grafton Gyzm, Tiberio Frisoli, James Lee, Lindsey Aurora, Sarah Gorgis, Hassan (..)
BackgroundVenoarterial extracorporeal membrane oxygenation (VA‐ECMO) is increasingly used for patients with cardiogenicshock. Although Impella or intra‐aortic balloon pump (IABP) is frequently used for left ventricular unloading (LVU) during VA‐ECMO treatment, there are limited data on comparative outcomes. P<0.001).ConclusionsIn
with SmartAssist and Impella CP with SmartAssist heart pumps, granting premarket approval (PMA) for use in specific pediatric patients with symptomatic acute decompensated heart failure (ADHF) and cardiogenicshock. and Impella CP, both left-sided heart pumps, for pediatric patients with symptomatic ADHF and cardiogenicshock.
Cardiogenicshock (CS)is the most feared event following STEMI. Outcome There are differing data about prognosis of CS in STEMI vs NSTEMI. Ironically, in many patients of CS in NSTEMI, the outcome can be worse than STEMI, as there is no single culprit and myocardial salvage does not appear to be a primary issue.
Patients at each shock stage may behave and present differently with a spectrum of shock severity and adverse outcomes. Shock severity, shock aetiology, and several factors should be integrated in management decision-making.
Cardiogenicshock (CS) remains a significant challenge in cardiovascular medicine, characterized by substantial morbidity and mortality. Historically, patient outcomes in CS have been varied, highly dependent on the timeliness of interventions and the expertise available at treating centers.
Cardiogenicshock rates were highest among SV-CHD patients, with significant fluctuations, followed by DV-CHD patients. Variations in cardiogenicshock, MCS usage, and cardiac transplants emphasize the need for adaptive clinical practices to optimize patient outcomes. Patients without CHD were older (mean age 71.5
Aims Among patients with cardiogenicshock, immediate initiation of extracorporeal membrane oxygenation (ECMO) did not demonstrate any benefit at 30days. The present study evaluated 1-year clinical outcomes of the Extracorporeal Membrane Oxygenation in the therapy of CardiogenicShock (ECMO-CS) trial.
Ventilatory modalities in cardiogenicshock: insights from the AltShock-2 registry. Aims To describe the use and the relation to outcome of different ventilation strategies in a contemporary, large, prospective registry of cardiogenicshock patients.
BackgroundClinical outcome of ischemic cardiogenicshock (CS) requiring extracorporeal membrane oxygenation is highly variable, necessitating appropriate assessment of prognosis. Journal of the American Heart Association, Ahead of Print. Fifteen parameters were selected to assess in‐hospital mortality.
Atrial fibrillation (AF) is a common sequela in cardiogenicshock (CS) and portends a worse prognosis. Despite its potential to worsen shock, no large-scale studies have investigated the impact of CV on patient outcomes. Electrical cardioversion (CV) is often employed for sinus rhythm restoration.
Background Data are lacking on the effects of the alternation of P2Y12 receptor antagonists (P2Y12) on bleeding and outcome in patients with myocardial infarction (MI) with cardiogenicshock (CS). We compared the effects of different P2Y12 and alternation of P2Y12 (combination) on bleeding and outcome in patients with MI and CS.
Cardiogenicshock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown to improve survival over the past few decades. A slowly maturing evidence base has suggested that cardiogenicshock teams may improve patient outcomes.
BackgroundVenoarterial extracorporeal membrane oxygenation (ECMO) provides full hemodynamic support for patients with cardiogenicshock, but optimal timing of ECMO initiation remains uncertain. 1.10];P<0.001).
Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in patients with acute myocardial infarction-related cardiogenicshock (AMICS). Conclusion This is the largest, most recent European cohort study describing outcomes, adverse events, and resource demands based on claims data in patients with Impella and/or VA-ECMO.
BACKGROUND:In patients with ST-segment–elevation myocardial infarction complicated by cardiogenicshock, primary percutaneous coronary intervention (pPCI) is the preferred revascularization option. The incidence of the primary safety outcome was 10.1% pharmacoinvasive and 46.2% pharmacoinvasive and 46.2% 1.09];P=0.08).CONCLUSIONS:In
Introduction Cardiogenicshock (CS) complicates 5%–15% of cases of acute myocardial infarction (AMI) with inpatient mortality greater than 40%. The implementation of standardised protocols may improve clinical outcomes in patients with AMI-CS.
BackgroundThe Society for Cardiovascular Angiography and Interventions proposed a staging system (A–E) to predict prognosis in cardiogenicshock. Patients enrolled in the RECOVER III study were assigned a baseline Society for Cardiovascular Angiography and Interventions shock stage. P<0.001).ConclusionsIn
Using inverse probability treatment weighting, we assessed for the association between device type and clinical outcomes. The primary outcome was allcause mortality. The primary outcome was allcause mortality. We identified 2879 patients without CS who underwent PCI with either an intraaortic balloon pump or microaxial LVAD.
The quarterly prevalence and outcomes were reported. ConclusionsOur study revealed substantial changes in the use of different mechanical circulatory support modalities in acute coronary syndrome complicated with cardiogenicshock, but they did not significantly improve the outcomes. in the first quarter of 2019 to 58.3%
Clinical presentation, shock severity and mortality in patients with de novo versus acute-on-chronic heart failure-related cardiogenicshock. ACHF-CS, acute-on-chronic failure-related cardiogenicshock; CI, confidence interval; DNHF-CS, de novo heart failure-related cardiogenicshock; HR, hazard ratio.
Abstract Objectives This study aimed to assess the impact of anemia and iron deficiency (ID) on clinical outcome in patients with cardiogenicshock (CS) complicating acute myocardial infarction (AMI). Nevertheless, data concerning the impact of anemia and ID on clinical outcome in patients with CS are scarce.
BackgroundMultidisciplinary teams and regionalized care systems have been suggested to improve cardiogenicshock (CS) outcomes. Journal of the American Heart Association, Ahead of Print. Methods and ResultsConsecutive patients with CS were evaluated (N=1162).
In acute heart failure caused by VHD, symptoms result from rapid haemodynamic changes and subsequent decline in cardiac function, and if left untreated, leads to acute decompensation and cardiogenicshock. After screening a total of 2234 articles, 76 published between 1994 and 2023 were included in subsequent analysis.
Now appears to be in cardiogenicshock." However, cardiogenicshock usually takes some time to develop, so it is probably subacute." Cardiogenicshock and ACS is an indication for the cath lab, even if you don't think there is OMI. I was texted these ECGs. Then SOB and nausea the next day.
Additionally, acute heart failure (AHF) can occur in up to 40% of cases, and its presence can impact the clinical outcomes of patients with IE. Cardiogenicshock (CGS) is often more likely to occur after AHF has taken place. If bacteria invade the blood, infectious shock can occur.
We aimed to investigate the prevalence and outcomes of patients with SMuRF-less ACS undergoing percutaneous coronary intervention (PCI) compared with those with SMuRFs. The primary outcome was 30-day mortality. Secondary outcomes included in-hospital and 30-day events. Patients with coronary artery disease were excluded.
Magenta's technology stands at the forefront of innovation in the MCS field and has the potential to significantly improve outcomes in patients with severe cardiovascular conditions,” said Eric Snyder, Partner, Venture Investments, Novo Holdings US. “We The financing will be used to advance the company’s U.S. Magenta completed a U.S.
There are conflicting sources regarding the relationship between hyperglycemia and outcomes in STEMI patients. We aimed to compile evidence to assess the association between hyperglycemia and adverse outcomes. Mortality was the most often outcome reported related to hyperglycemia. 3.45) and 4.47 (95% CI: 2.54–7.87),
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