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A summary of current and novel biomarkers and their potential stages of release in cardiogenicshock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenicshock: progression from cardiac dysfunction/stress, through to inflammation and end-organ dysfunction.
Background Cardiogenicshock (CS) induced by severe aortic stenosis (AS) is a life-threatening condition with high mortality. In-hospital mortality pooled estimated rates were 11% for eTAVI (CI 0.06 - 0.18) and for eBAV 40% (CI 0.28 - 0.54). Methods A systematic literature review and meta-analysis was performed.
Background Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenicshock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes.
Windtree Therapeutics’ istaroxime appears to have scored in its latest Phase 2b trial , showing that the steroidal drug significantly improves systolic blood pressure in cardiogenicshock patients. That could be a big deal in the cardiogenicshock space, which many believe is still in need of more effective treatments.
Cardiogenicshock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. Age is a nonmodifiable risk factor for mortality in patients with cardiogenicshock and is often considered in the decision-making process for eligibility for various therapies.
Publication date: Available online 24 January 2025 Source: The American Journal of Cardiology Author(s): Eric J. Hall, Colby R. Ayers, Nicholas S. Hendren, Christopher Clark, Amit Saha, Hadi Beaini, Isabella L. Alexander, Evan P. Gee, Ian R. McConnell, Emily S. Samson, Roslyn J. Saplicki, Christopher S. Grubb, Grant Tucker, Justin L.
with SmartAssist and Impella CP with SmartAssist heart pumps, granting premarket approval (PMA) for use in specific pediatric patients with symptomatic acute decompensated heart failure (ADHF) and cardiogenicshock. and Impella CP, both left-sided heart pumps, for pediatric patients with symptomatic ADHF and cardiogenicshock.
BackgroundVenoarterial extracorporeal membrane oxygenation (VA‐ECMO) is increasingly used for patients with cardiogenicshock. Although Impella or intra‐aortic balloon pump (IABP) is frequently used for left ventricular unloading (LVU) during VA‐ECMO treatment, there are limited data on comparative outcomes. versus 25.8%;P‐trend<0.001).
BackgroundClinical outcome of ischemic cardiogenicshock (CS) requiring extracorporeal membrane oxygenation is highly variable, necessitating appropriate assessment of prognosis. Fifteen parameters were selected to assess in‐hospital mortality. Journal of the American Heart Association, Ahead of Print.
Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in patients with acute myocardial infarction-related cardiogenicshock (AMICS). Impella patients were older (34% vs. 13% >75 years, p < 0.001) and less frequently presented after an out-of-hospital cardiac arrest (18% vs. 40%, p < 0.001).
The quarterly prevalence and outcomes were reported. After adjusting for the confounders, the risk difference in the fourth quarter of 2021 relative to the first quarter of 2019 for in‐hospital mortality was not significant (adjusted odds ratio, 0.84 [95% CI, 0.69–1.01]).ConclusionsOur in the first quarter of 2019 to 58.3%
Abstract Worldwide, valvular heart disease (VHD) is a common cause of hospitalization for acute heart failure. In acute heart failure caused by VHD, symptoms result from rapid haemodynamic changes and subsequent decline in cardiac function, and if left untreated, leads to acute decompensation and cardiogenicshock.
Introduction The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in extracorporeal cardiopulmonary resuscitation (ECPR) in selected patients after out-of-hospital cardiac arrest (OHCA) is an established method if return of spontaneous circulation cannot be achieved.
Magenta's technology stands at the forefront of innovation in the MCS field and has the potential to significantly improve outcomes in patients with severe cardiovascular conditions,” said Eric Snyder, Partner, Venture Investments, Novo Holdings US. “We Francis Hospital and Heart Center , both in New York. Magenta completed a U.S.
In the light of increasing availability, the analyses of outcome-relevant predisposing characteristics are of growing importance. We evaluated the prognostic influence of gender in patients presenting with out-of-hospital cardiac arrest (OHCA) treated with eCPR.
We aimed to investigate the prevalence and outcomes of patients with SMuRF-less ACS undergoing percutaneous coronary intervention (PCI) compared with those with SMuRFs. The primary outcome was 30-day mortality. Secondary outcomes included in-hospital and 30-day events. Patients with coronary artery disease were excluded.
As heart failure with preserved ejection fraction (HFpEF) comprises half of all heart failure cases, understanding its management and effect on outcomes is crucial. Multivariate logistic and linear regression analyses were performed, adjusting for multiple patient and hospital confounders.
Patient characteristics, outcomes, and procedural volume were compared among 3 cohorts: admissions to non-ATCs, admissions to ATCs, and transfers to ATCs. A secondary analysis evaluated outcomes for severe HF hospitalizations (cardiogenicshock, cardiac arrest, and mechanical ventilation).
As a low-volume PCI centre in the Middle East, we wanted to find out if the outcomes of our PCI procedures are different from those of high-volume PCI centres in the UK and the Western world. Prospectively collected data of all comers for PCI (urgent and elective) were retrospectively analysed. and the average number of stents 2.6.
Abstract Aims To evaluate the association between transcatheter edge-to-edge repair (TEER) and outcomes in patients with significant mitral regurgitation (MR) following acute myocardial infarction (MI), focusing on the aetiology of acute post-MI MR in high-risk surgical patients.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Admissions to CICUs with the highest tertile of CCRx utilization had a greater burden of comorbidities, had more diagnoses of ST–elevation myocardial infarction, cardiac arrest, or cardiogenicshock, and had higher Sequential Organ Failure Assessment scores.
Organ perfusion pressure as a predictor of outcomes in cardiogenicshock: insights from the Altshock-2 registry. ABSTRACT Aims The diagnosis of cardiogenicshock (CS) relies upon signs and/or symptoms of end-organ hypoperfusion. The primary outcome was in-hospital all-cause mortality. Low OPP (i.e. <57.0mmHg)
BackgroundPatients with severe mitral regurgitation and cardiogenicshock demonstrate a poor prognosis. The primary outcome was device success and allcause death, while secondary outcomes included myocardial infarction, stroke, and heart failure hospitalization rates at 30day and intermediateterm followup.
Thus, this ECG predicts poor myocardial perfusion and poor outcome. His included cardiogenicshock, V Tach, AV block. He was hospitalized for 16 days. Small vessel occlusion is measured by "blush" on the angiogram, and codified by TIMI Myocardial Perfusion (TMP) Grading. Such large infarcts have many complications.
Henry Ford Health's National CardiogenicShock Initiative research team. Cardiogenicshock is a critical condition in which the heart is unable to pump enough blood to sustain the body’s needs, depriving vital organs of blood supply. This can cause those organs to eventually stop functioning.
An elderly man with sudden cardiogenicshock, diffuse ST depressions, and STE in aVR Literature 1. However, STE-aVR with multilead ST depression was associated with 31% in-hospital mortality compared with only 6.2% 2 cases of Aortic Stenosis: Diffuse Subendocardial Ischemia on the ECG. Left main? 3-vessel disease? Knotts et al.
BACKGROUND:There are limited large-scale data on the outcomes of patients with cardiogenicshock (CS) transferred to hub centers. Overlap propensity score weighting was performed to assess the association between transfer status and in-hospital mortality. In-hospital mortality was lower in transferred patients39.1%
Aims Among patients with cardiogenicshock, immediate initiation of extracorporeal membrane oxygenation (ECMO) did not demonstrate any benefit at 30days. The present study evaluated 1-year clinical outcomes of the Extracorporeal Membrane Oxygenation in the therapy of CardiogenicShock (ECMO-CS) trial.
BACKGROUND:In patients with ST-segment–elevation myocardial infarction complicated by cardiogenicshock, primary percutaneous coronary intervention (pPCI) is the preferred revascularization option. The incidence of the primary safety outcome was 10.1% pharmacoinvasive and 46.2% pharmacoinvasive and 46.2% 1.09];P=0.08).CONCLUSIONS:In
BackgroundVenoarterial extracorporeal membrane oxygenation (ECMO) provides full hemodynamic support for patients with cardiogenicshock, but optimal timing of ECMO initiation remains uncertain. Multivariable logistic regression evaluated the association between time from admission to ECMO initiation and in‐hospital death.
Abstract Objectives This study aimed to assess the impact of anemia and iron deficiency (ID) on clinical outcome in patients with cardiogenicshock (CS) complicating acute myocardial infarction (AMI). Nevertheless, data concerning the impact of anemia and ID on clinical outcome in patients with CS are scarce.
BackgroundPatients hospitalized with COVID19 from socioeconomically vulnerable communities are at risk for inhospital cardiovascular events. A total of 3783 (52%) patients experienced a composite outcome. Findings suggest targeting public health efforts toward dual eligible patients to mitigate poor outcomes.
We reviewed the characteristics and in-hospitaloutcomes and developed a novel risk score for TC. Multivariable regression analysis was conducted to identify factors associated with TC diagnosis and adverse outcomes, leading to the development of a risk-scoring system. for other ACS) in-hospital mortality events.
Background:Cardiogenic shock (CS) has high morbidity and mortality rates. Among AMI-CS hospitalizations, Black patients were less likely to receive IABP (aOR: 0.87, 95%CI: 0.82-0.93), Among AMI-CS hospitalizations, Black patients were less likely to receive IABP (aOR: 0.87, 95%CI: 0.82-0.93), 0.93), pLVAD (aOR: 0.79, 95%CI: 0.72-0.86),
Prevalence, clinical characteristics, and short‐ and long‐term outcomes of patients with TTS were recorded. The aim of the study was to evaluate TTS‐associated neurological phenotypes and outcome.Methods and ResultsPatients with TTS enrolled in the international multicenter GEIST (German Italian Spanish Takotsubo) registry were analyzed.
INTRODUCTION:Percutaneous coronary intervention for complex coronary disease is associated with a high risk of cardiogenicshock. Cardiogenicshock and acute ST-segment–elevation myocardial infarction are exclusions. Circulation: Cardiovascular Interventions, Ahead of Print.
Assessment was severe sudden cardiogenicshock. However, in multiple studies, even in the absence of AMI, both acute and chronic myocardial injury (as diagnosed by any elevated cTn) are powerful markers of adverse outcomes in both the short and long term. Clinically — the patient was felt to be in cardiogenicshock.
TIMI flow 0) is rare in the ED, as most either die before arrival or are recognized clinically due to cardiogenicshock. 67) Less than 3% of anterior STEMI has LM OMI, and most are recognized clinically due to cardiogenicshock. (68, Current Emergency and Hospital Medicine Reports 2013;1:43-52.
The patient went into cardiogenicshock and ultimately died of this MI. Setting Secondary and tertiary care hospitals in the United Kingdom and United States. Main outcome measures Positive predictive value of an elevated cardiac troponin concentration for a diagnosis of type 1 myocardial infarction. to 18.2%).
Adult Cardiac Surgery Database Lead Author Title Publication Date Jacob Raphael Red Blood Cell Transfusion and Pulmonary Complications: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis The Annals of Thoracic Surgery January 2024 Joseph Sabik Multi-Arterial versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million (..)
Program Designations Access and Publications (A&P) 1 Participant User File (PUF) 2 Task Force on Funded Research (TFR) 3 Special Projects 4 Adult Cardiac Surgery Database Lead Author Title Publication Date William Keeling 2 National Trends in Emergency Coronary Artery Bypass Grafting European Journal of Cardiothoracic Surgery October 2023 Jake (..)
Objective This study describes the differences in treatment and clinical outcomes in patients aged ≥75 years compared with those aged ≤74 years presenting with acute coronary syndrome (ACS) and undergoing invasive management. Patients aged ≥75 years are more likely to die in-hospital than younger patients.
The Golden Hour post the Myocardial infarction (MI) It is a matter of great concern that 50% of individuals experiencing an acute heart attack pass away before reaching the hospital. It is imperative to act swiftly when faced with such a medical emergency to ensure the best possible outcome.
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