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Interplay between mitochondrial dysfunction and lysosomal storage: challenges in genetic metabolic muscle diseases with a focus on infantile onset Pompe disease

Frontiers in Cardiovascular Medicine

Background Pompe disease (PD) is a rare, progressive autosomal recessive lysosomal storage disorder that directly impacts mitochondrial function, leading to structural abnormalities and potentially culminating in heart failure or cardiogenic shock.

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Critical Left Main

EMS 12-Lead

Echocardiogram findings (pre-procedure) 1. Mitral valve calcification with mild regurgitation Laboratory data (pre-procedure) 1. Had such been the case, this patient would likely have been a prehospital cardiac arrest, or have been in profound cardiogenic shock at the time of ED arrival. Stage II diastolic dysfunction 3.

Angina 52
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Chest Pain and Inferior ST Elevation.

Dr. Smith's ECG Blog

I have always said that tachycardia should argue against acute MI unless there is cardiogenic shock or 2 simultaneous pathologies. The patient underwent an emergent formal echocardiogram to look for wall motion abnormality: The estimated left ventricular ejection fraction is 63 %. PR depression, which suggests pericarditis 4.