Cardiac Function and Pharmacology - Cardiovascular Update

Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy

Frontiers in Cardiovascular Medicine

MARCH 14, 2025

ZGCD not only significantly reduces blood pressure, but also enhances cardiac function while producing fewer adverse effects. Meanwhile, the utilization of ZGCD during intervention was more effective in reducing SBP, and DBP. In addition, the ZGCD showed potential in reducing the occurrence of adverse events.

Pharmacology

Pharmacology Cardiomyopathy Diabetes Blood Pressure

New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

DAIC

JUNE 7, 2024

In CAVD, microcrystals of hydroxyapatite (a calcium phosphate mineral) deposit onto the heart valve leaflets and impair cardiac function. The disease has a dismal prognosis with most untreated patients dying two years after diagnosis.

Aortic valve

Aortic valve Aortic Heart Valves Pharmacology

USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

DAIC

DECEMBER 12, 2023

Since mitochondrial protein synthesis is critical to its structure, as well as normal cardiac function, the authors focused much of their study on how alteration of the mitochondrial protein balance affects heart health.

Heart Attack

Heart Attack Heart attacks Heart Disease Pharmacology

Abstract 4140419: Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils from Human Pluripotent Stem Cells

Circulation

NOVEMBER 11, 2024

Cardiac fibrosis is a pathological hallmark of almost all forms of heart disease, characterized by excessive deposition of extracellular matrix (ECM) proteins by activated fibroblasts, leading to cardiomyocyte hypertrophy, arrhythmias, and heart failure.

Cardiac Function

Cardiac Function Pharmacology Innovation Heart Failure

Ovarian Tumor Domain?Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel?Like Factor 4

Journal of the American Heart Association

DECEMBER 12, 2023

Currently, no pharmacological interventions have been specifically tailored to treat CH. Furthermore, OTUD7B deficiency exacerbated transverse aortic coarctation surgery‐induced myocardial hypertrophy, abnormal cardiac function, and fibrosis.

Pharmacology

Pharmacology Aortic Cardiac Function Risk Factors

Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

OCTOBER 17, 2023

Abstract Aims Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.

Heart Failure

Heart Failure Preserved Ejection Fraction Circulation Pharmacology

Protective Effect of CD137 Deficiency against Post-infarction Cardiac Fibrosis and Adverse Cardiac Remodeling via ERK1/2 Signaling Pathways

Journal of Cardiovascular Pharmacology

FEBRUARY 11, 2024

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared to wild-type mice at day 28 post-MI.

Cardiac Function

Cardiac Function Myocardial Infarction Article

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Circulation

NOVEMBER 14, 2023

We investigated the effect of ERR agonist on cardiac function in a pressure overload–induced HF model in vivo. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics.

Heart Failure

Heart Failure Pharmacology Cardiac Function Circulation

Canonical Transient Receptor Potential (TRPC) Channels in Cardiovascular Pathology and their Modulators

Journal of Cardiovascular Pharmacology

OCTOBER 14, 2024

Ion channels play a crucial role in various aspects of cardiac function, such as regulating rhythm and contractility. Cell function is substantially influenced by the concentration of free cytosolic calcium (Ca2+) and the voltage across the plasma membrane.

Cardiovascular Disease

Cardiovascular Disease Cardiac Function Article Physiology

Canagliflozin mediates mitophagy through the AMPK/PINK1/PARKIN pathway to alleviate isoprenaline-induced cardiac remodelling

Journal of Cardiovascular Pharmacology

AUGUST 12, 2024

Furthermore, the differential expression of AMPK/PINK1/Parkin pathway-related proteins in ISO-induced cardiac remodeling was effectively reversed by canagliflozin, suggesting the therapeutic potential of targeting this pathway with the drug. Heart failure has always been a prevalent, disabling, and potentially life-threatening disease.

Heart Failure

Heart Failure Cardiac Function Research Article

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Journal of Cardiovascular Pharmacology

JULY 23, 2024

Serial echocardiography and pressure-volume loops were utilized to assess cardiac function and hemodynamics. Serial echocardiography and pressure-volume loops were utilized to assess cardiac function and hemodynamics. In contrast, combination therapy resulted in significant improvement.

Bicuspid/Mitral

Bicuspid/Mitral Cardiac Function Heart Failure Circulation

The protective effects of ruscogenin against lipopolysaccharide-induced myocardial injury in septic mice

Journal of Cardiovascular Pharmacology

MARCH 24, 2024

We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice. We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice.

Cardiac Function

Cardiac Function Article

EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION

Journal of Cardiovascular Pharmacology

APRIL 4, 2024

PTE administration promoted protective effects in terms of oxidative stress in two experimental models of cardiac diseases: MI and PAH. PTE also improved cardiac function in infarcted rats and pulmonary artery flow in animals with PAH. In the PAH model, PTE improved pulmonary artery flow and decreased ROS levels in the lung.

Myocardial Infarction

Myocardial Infarction Cardiovascular Disease Pulmonary Hypertension

Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function.

Cardiac Function

Cardiac Function Ischemia Article

ALKBH5 regulates N(6)-methyladenosine (m6A) methylation of MG53 to attenuate myocardial infarction by inhibiting apoptosis and oxidative stress

Journal of Cardiovascular Pharmacology

NOVEMBER 16, 2023

Overexpression of ALKBH5 inhibited H/R-induced cardiomyocyte apoptosis and oxidative stress in vitro, and inhibited I/R-induced collagen deposition, cardiac function, and apoptosis in vivo. We observed that ALKBH5 and MG53 were highly expressed in MI. We observed that ALKBH5 and MG53 were highly expressed in MI.

Myocardial Infarction

Myocardial Infarction Cardiac Function Ischemia Article

Sulforaphane improves redox homeostasis and right ventricular contractility in a model of pulmonary hypertension

Journal of Cardiovascular Pharmacology

MARCH 13, 2024

Data express a benefit of SFN treatment on the cardiac function of rats with PAH associated with the cellular redox state. Data express a benefit of SFN treatment on the cardiac function of rats with PAH associated with the cellular redox state. Catalase and GSH/GSSG ratio were diminished in MCT compared to CTR (P<0.05).

Pulmonary

Pulmonary Hypertension Tricuspid Cardiac Function

Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia

Journal of Cardiovascular Pharmacology

NOVEMBER 22, 2023

Echocardiography was used to estimate cardiac function. Echocardiography was used to estimate cardiac function. After 6 weeks, some WT mice (n=24) in CIH group were given sildenafil or saline gavage for another 4 weeks. Blood pressure was regularly measured during the experiment.

Blood Pressure

Blood Pressure Cardiac Function Article

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction

Frontiers in Cardiovascular Medicine

JANUARY 20, 2025

Despite its known effects on cholesterol metabolism, the role of PCSK9 in cardiac function, especially post-myocardial infarction (MI), remains unclear. Cardiac function was assessed via echocardiography and isolated working heart model experiments. PCSK9 and LDL receptor levels were measured using ELISA and qRT-PCR.

Myocardial Infarction

Myocardial Infarction Cardiac Function Cholesterol Pharmacology

Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy

New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

Abstract 4140419: Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils from Human Pluripotent Stem Cells

Ovarian Tumor Domain?Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel?Like Factor 4

Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

Protective Effect of CD137 Deficiency against Post-infarction Cardiac Fibrosis and Adverse Cardiac Remodeling via ERK1/2 Signaling Pathways

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Canonical Transient Receptor Potential (TRPC) Channels in Cardiovascular Pathology and their Modulators

Canagliflozin mediates mitophagy through the AMPK/PINK1/PARKIN pathway to alleviate isoprenaline-induced cardiac remodelling

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

The protective effects of ruscogenin against lipopolysaccharide-induced myocardial injury in septic mice

EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION

Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance

ALKBH5 regulates N(6)-methyladenosine (m6A) methylation of MG53 to attenuate myocardial infarction by inhibiting apoptosis and oxidative stress

Sulforaphane improves redox homeostasis and right ventricular contractility in a model of pulmonary hypertension

Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction

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