Journal of Cardiovascular Pharmacology

NOVEMBER 16, 2023

Abstract: N(6)-methyladenosine (m6A) methylation modification is involved in the progression of myocardial infarction (MI). Overexpression of ALKBH5 inhibited H/R-induced cardiomyocyte apoptosis and oxidative stress in vitro, and inhibited I/R-induced collagen deposition, cardiac function, and apoptosis in vivo.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Ischemia Article 40

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

The intergroup comparison showed the therapeutic effect of the combination was equivalent in HF caused by myocardial Infarction (MI), dilated cardiomyopathy (DCM) or Valvular Heart Disease (VHD).ConclusionVericiguat and improved patients’ quality of life scores.

Heart Failure 52

Heart Failure Preserved Ejection Fraction Cardiac Function Quality of Life 52

DAIC

APRIL 30, 2024

Myocardial infarctions , commonly known as “heart attacks,” are on the rise, resulting in a significant number of deaths each year. Heart attacks typically kill millions of cardiac muscle cells, leaving the heart in a weakened state. First, the team verified the correct reprogramming of HiPSCs into cardiomyocytes.

Transplant 105

Transplant Heart Transplant Myocardial Infarction Heart Attack 105

Journal of the American Heart Association

FEBRUARY 14, 2025

BackgroundBranchedchain amino acids (BCAAs), which are derived from the diet, are markedly elevated in cardiac tissue following myocardial infarction (MI). The low BCAA diet preserved stroke volume and cardiac output after MI, whereas the high BCAA diet promoted progressive decreases in cardiac function.

Diet 45

Diet Cardiac Function Myocardial Infarction Circulation 45

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Moreover, blocking chemokine CXCR2 to inhibit the specification of the S100a9+Ly6c+-biased inflammatory fate in P10 hearts resulted in elevated wound repair responses and marked improvements in cardiac function after injury.

Myocardial Infarction 52

Myocardial Infarction Cardiac Function 52

European Journal of Heart Failure

MARCH 11, 2025

Abstract Aims Sodiumglucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. Two weeks after surgery, mice were randomized to 6weeks of empagliflozin or vehicle treatment.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Circulation 40

Journal of Cardiovascular Pharmacology

FEBRUARY 11, 2024

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. The specific role of CD137 in the development of post-MI myocardial fibrosis remains unclear. Copyright © 2024 Wolters Kluwer Health, Inc.

Cardiac Function 40

Cardiac Function Myocardial Infarction Article 40

Dr. Smith's ECG Blog

SEPTEMBER 11, 2024

Electrocardiographic Criteria to Differentiate Acute Anterior ST Elevation Myocardial Infarction from Left Ventricular Aneurysm. Acute MI per se usually does not depress cardiac function and blood pressure enough to cause syncope ( Mostafa et al — J Com Hosp Intern Med Perspect 13(4):9-12, 2023 - ).

Chest Pain 115

Chest Pain Aneurysm Stents Stent 115

Circulation

NOVEMBER 11, 2024

Mean patient age was 55 yrs, 56% (n=575) were women, and comorbid conditions were frequent: hypertension (64.1%), dyslipidemia (46.1%), diabetes (25.7%), documented coronary artery disease (19.3%), previous revascularization (20.6%), previous myocardial infarction (10.1%). Length of stay (LOS) in the CPU to discharge was 10.4

Chest Pain 40

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease 40

Circulation

OCTOBER 27, 2023

Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and compositional changes in the extracellular matrix. Conditional knockout ofVcanin cardiac fibroblasts decreased cardiomyocyte proliferation and impaired neonatal heart regeneration.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Heart Disease Circulation 40

Circulation

NOVEMBER 11, 2024

Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Aortic 40

Circulation

FEBRUARY 23, 2024

BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Circulation, Ahead of Print.

Myocardial Infarction 45

Myocardial Infarction Cardiac Function Biomarkers Heart Failure 45

All About Cardiovascular System and Disorders

MARCH 7, 2024

Experimental studies have suggested that micro and nanoplastics promote oxidative stress, inflammation and apoptosis in endothelial and other vascular cells which could lead to impairement in cardiac function, myocardial fibrosis and endothelial dysfunction [4]. Inflammatory biomarkers were also estimated.

Plaque 52

Plaque Myocardial Infarction Laboratory Cardiac Function 52

Dr. Smith's ECG Blog

JULY 21, 2024

Troponin T peaked at 38,398 ng/L ( = a very large myocardial infarction, but not massive-- thanks to the pre-PCI spontaneous reperfusion, and rapid internvention!! ). Cardiac function is poor, with akinesis of the LAD territory. Inotropic medication was continued.

Arrhythmia 132

Arrhythmia Cardiogenic Shock Bradycardia Defibrillator 132

Dr. Smith's ECG Blog

MARCH 6, 2019

Thus, the available evidence supports the common sense theory that even asymptomatic patients with persistent ECG evidence of full thickness infarction (Occlusion MI) should receive emergent angiogram and PCI. Timing of Revascularization in Patients with Transient ST-Segment Elevation Myocardial Infarction: A Randomized Clinical Trial.

STEMI 52

STEMI Chest Pain Ischemia Myocardial Infarction 52

Cardiomatics

FEBRUARY 9, 2022

This results in a deficiency of oxygen and nutrients in the cells of the body, which can have a huge impact on how it functions. Moreover, the improvement of care for patients with myocardial infarction has resulted in higher survival rates, but as a result, more patients suffer from heart failure.

Heart Failure 52

Heart Failure Myocardial Infarction Medicare Defibrillator 52

Heart BMJ

NOVEMBER 25, 2024

Background and aims Current ESC guidelines on the management of patients after acute myocardial infarction only include the evaluation of left ventricular (LV) function by assessment of the ejection fraction in addition to clinical risk scores to estimate the patient’s prognosis.

Myocardial Infarction 52

Myocardial Infarction Coronary Artery Disease Blood Pressure Tricuspid 52

Frontiers in Cardiovascular Medicine

JANUARY 6, 2025

ObjectiveTo investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset post-myocardial infarction heart failure (HF).MethodsA

Myocardial Infarction 52

Myocardial Infarction Cardiac Function Heart Failure Research 52

Frontiers in Cardiovascular Medicine

JANUARY 20, 2025

Despite its known effects on cholesterol metabolism, the role of PCSK9 in cardiac function, especially post-myocardial infarction (MI), remains unclear. Cardiac function was assessed via echocardiography and isolated working heart model experiments.

Myocardial Infarction 52

Myocardial Infarction Cardiac Function Cholesterol Pharmacology 52