Cardiac Function and Hypertension - Cardiovascular Update

GOLD 2025 Report: Addressing Heart Disease in COPD

HCPLive

JANUARY 31, 2025

In stable COPD, cardiovascular complications are a leading cause of mortality, whereas acute exacerbations can worsen heart function. Key treatable traits in COPD-associated pulmonary hypertension include hypoxemia, inflammation, and right ventricular dysfunction.

Heart Disease

Heart Disease Cardiac Function Pulmonary Hypertension

Scientists discover first therapeutic target for preserving heart function in patients with pulmonary hypertension

Medical Xpress - Cardiology

JANUARY 19, 2024

A research team has discovered a possible therapeutic target for pulmonary hypertension.

Pulmonary

Pulmonary Hypertension Cardiac Function Research

Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor?Associated Hypertension

Journal of the American Heart Association

FEBRUARY 29, 2024

BackgroundMyosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho‐MLC (p‐MLC).

Hypertension

Hypertension Blood Pressure Cardiac Function

Myocardial Interstitial Fibrosis in Hypertensive Heart Disease: From Mechanisms to Clinical Management

Hypertension Journal

DECEMBER 12, 2023

Hypertension, Ahead of Print. Hypertensive heart disease (HHD) can no longer be considered as the beneficial adaptive result of the hypertrophy of cardiomyocytes in response to pressure overload leading to the development of left ventricular hypertrophy.

Heart Disease

Heart Disease Hypertension Cardiac Function Research

Relationship Between RNF213 p.R4810K and Echocardiographic Findings in Patients with Cerebrovascular Diseases: A Multicenter Prospective Cohort Study

Journal of the American Heart Association

JANUARY 27, 2025

Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension. BackgroundRING finger protein 213 (RNF213) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people.

Cerebrovascular Disease

Cerebrovascular Disease Pulmonary Cardiac Function Hypertension

Sulforaphane improves redox homeostasis and right ventricular contractility in a model of pulmonary hypertension

Journal of Cardiovascular Pharmacology

MARCH 13, 2024

Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance, imposing overload on the right ventricle (RV) and imbalance of redox state. Data express a benefit of SFN treatment on the cardiac function of rats with PAH associated with the cellular redox state. Treatment with SFN (2.5

Pulmonary

Pulmonary Hypertension Tricuspid Cardiac Function

EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION

Journal of Cardiovascular Pharmacology

APRIL 4, 2024

Myocardial infarction (MI) and pulmonary artery hypertension (PAH) are two prevalent cardiovascular diseases. PTE administration promoted protective effects in terms of oxidative stress in two experimental models of cardiac diseases: MI and PAH. In both conditions, oxidative stress is associated with a worse prognosis.

Myocardial Infarction

Myocardial Infarction Cardiovascular Disease Pulmonary Hypertension

Abstract 4134796: Safety of over 1000 consecutive, selected low risk patients with accelerated discharge from a chest pain unit with early generation cardiac troponin use, no cardiac functional or anatomic testing and no clinical risk scores

Circulation

NOVEMBER 11, 2024

We assessed demographics, comorbidities, medications, and major cardiac events at 30 d and 6 mos post-discharge.Results:The study group of 1037 pts comprised 26% of the 4010 pts admitted to the CPU during the study interval from May 2005 to March 2015. Length of stay (LOS) in the CPU to discharge was 10.4

Chest Pain

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease

Abstract 4140979: CD34+ Cells Contributed to Cardiac Fibrosis Are Regulated by Hyperlipidemia

Circulation

NOVEMBER 11, 2024

Background:Lipid metabolic alterations are emerging as significant mechanisms in the prognosis of cardiac remodeling induced by hypertension and could impact the therapies for cardiac fibrosis. Circulation, Volume 150, Issue Suppl_1 , Page A4140979-A4140979, November 12, 2024.

Hypertension

Hypertension Transplant Cardiac Function Circulation

Myocardial sodium–glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO?AS study

European Journal of Heart Failure

JANUARY 21, 2024

Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT2) gene and protein in patients with severe AS stratified in high gradient (HG) and low flow-low gradient (LF-LG) AS and its association with cardiac functional impairments.

Stenosis

Stenosis Aortic Aortic valve Coronary Artery Disease

Orthostatic hypotension onset after invasive procedure?

Dr. Smith's ECG Blog

JANUARY 13, 2024

If it does not sense a native rhythm (perhaps from lead fracture or displacement), it will attempt to pace at 60 beats per minute, which can cause unnecessary pacing spikes interrupting normal cardiac function. A few days later, midodrine and fludrocortisone were held due to hypertension and the patient was discharged.

Pacemaker

Pacemaker Bicuspid/Mitral Blood Pressure Bradycardia

Medications for Congenital Heart Disease: What Every Parent Should Know

Conquering CHD

JUNE 20, 2023

POTENTIAL SIDE EFFECTS : While diuretics can be effective in managing symptoms such as edema and hypertension, possible side effects include electrolyte imbalances, dehydration, and hypotension. Cardiac Glycosides WHAT THEY DO : Cardiac glycosides improve cardiac function in children with CHD.

Congenital Heart Disease

Congenital Heart Disease Congenital Heart Disease ACE Inhibitor

What will you do for this patient transferred to you who is now asymptomatic?

Dr. Smith's ECG Blog

MARCH 6, 2019

A middle-aged woman with history of hypertension presented to another hospital approximately 2 hours after onset of chest pain and shortness of breath. Compared with sustained STEMI, transient STEMI was associated with less myocardial damage, less extensive coronary artery disease, higher TIMI flow grade, and better cardiac function.

STEMI

STEMI Chest Pain Ischemia Myocardial Infarction

Identification of an increased lifetime risk of major adverse cardiovascular events in UK Biobank participants with scoliosis

Open Heart

MAY 3, 2023

Cardiac compression of the top and bottom of the heart and decompression of the sides was observed through S2S analysis. Additionally, associations between scoliosis and older age, female sex, heart failure, valve disease, hypercholesterolemia, hypertension and decreased enrolment for CMR were identified.

Heart Failure

Heart Failure Atrial Fibrillation Cardiac Function Hypertension

Cardiac function in pregnant women with preeclampsia

Frontiers in Cardiovascular Medicine

DECEMBER 15, 2024

While it has been demonstrated that PE may be a consequence of maternal cardiovascular maladaptation, the exact role of maternal cardiac function remains to be determined. ConclusionChanges in cardiac function in the context of hypertensive pregnancy diseases can be observed with regard to various echocardiographic parameters.

Cardiac Function

Cardiac Function Tricuspid Pulmonary Hypertension