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Associations of colchicine-related plasma proteins, incident heartfailure (HF) and cardiac structure and function. HFpEF, heartfailure with preserved ejection fraction; HFrEF, heartfailure with reduced ejection fraction.
BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heartfailure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiacfunction in a pressure overload–induced HF model in vivo. Circulation, Ahead of Print.
Since mitochondrial protein synthesis is critical to its structure, as well as normal cardiacfunction, the authors focused much of their study on how alteration of the mitochondrial protein balance affects heart health.
Cardiac fibrosis is a pathological hallmark of almost all forms of heart disease, characterized by excessive deposition of extracellular matrix (ECM) proteins by activated fibroblasts, leading to cardiomyocyte hypertrophy, arrhythmias, and heartfailure.
Heartfailure has always been a prevalent, disabling, and potentially life-threatening disease. For the treatment of heartfailure, controlling cardiac remodeling is very important. Heartfailure has always been a prevalent, disabling, and potentially life-threatening disease.
Although the mineralocorticoid-receptor antagonist spironolactone, in conjunction with renin-angiotensin system (RAS) inhibitors, has been shown to reduce mortality in patients with heartfailure with reduced ejection fraction (HFrEF), its efficacy in managing degenerative MR is uncertain.
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