CRISPR-Cas9 base editing of pathogenic CaMKII? improves cardiac function in a humanized mouse model
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is a prominent inducer of various cardiac disorders, which is mediated by 2 oxidation-sensitive methionine residues within the regulatory domain. Here, we extended this therapeutic concept toward potential clinical translation.
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