Remove Cardiac Function Remove CMS Remove Ischemia
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Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

Circulation

Here, we aimed to evaluate the role and mechanism of Nrf3 in injury-induced pathological cardiac remodeling.METHODS:Global (Nrf3-KO) and CM-specific (Nrf3CM) Nrf3 knockout mice were subjected to MI or ischemia/reperfusion injury, followed by functional and histopathological analysis.