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Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

Abstract Aims Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.

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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Circulation

Circulation, Ahead of Print. Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiac function in a pressure overload–induced HF model in vivo. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heart failure (HF).

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USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

DAIC

That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should.

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The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Journal of Cardiovascular Pharmacology

Serial echocardiography and pressure-volume loops were utilized to assess cardiac function and hemodynamics. Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins.