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Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

Abstract Aims Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.

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Abstract 4140419: Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils from Human Pluripotent Stem Cells

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Cardiac fibrosis is a pathological hallmark of almost all forms of heart disease, characterized by excessive deposition of extracellular matrix (ECM) proteins by activated fibroblasts, leading to cardiomyocyte hypertrophy, arrhythmias, and heart failure.

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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Circulation

Circulation, Ahead of Print. Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiac function in a pressure overload–induced HF model in vivo. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heart failure (HF).

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The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Journal of Cardiovascular Pharmacology

Serial echocardiography and pressure-volume loops were utilized to assess cardiac function and hemodynamics. Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins.

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USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

DAIC

That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should.