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Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction

Open Heart

Background In acute heart failure (HF), reduced cardiac output, vasoconstriction and congestion may damage the intestinal mucosa and disrupt its barrier function. This could facilitate the leakage of bacterial products into circulation and contribute to inflammation and adverse cardiac remodelling.

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Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3‐Butanediol in Patients With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association

BackgroundOral treatment with the exogenous ketone body 3hydroxybutyrate improves cardiac function in patients with heart failure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Twelve patients with heart failure with reduced ejection fraction were included. L/min (95% CI, 0.71.1

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Increased Plasma Pyruvate Kinase M2 (PK‐M2) in Heart Failure: A Novel Biomarker Related to Cardiac Function and its Clinical Implications

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThe purpose of this study was to investigate whether circulating pyruvate kinase M2 (PKM2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in patients with heart failure (HF).Methods versus 7.82.3

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INO80-Dependent Remodeling of Transcriptional Regulatory Network Underlies the Progression of Heart Failure

Circulation

Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. Cardiomyocyte-specific overexpression ofIno80, its core catalytic subunit, induced heart failure within 4 days.

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Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility in murine heart failure

European Journal of Heart Failure

Abstract Aims Sodiumglucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. Empagliflozin treatment resulted in a twofold increase in circulating ketone bodies.

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Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

Associations of colchicine-related plasma proteins, incident heart failure (HF) and cardiac structure and function. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.

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Abstract 4144084: Enhanced External Counterpulsation as a Novel Treatment for Heart Transplant Candidates with Ischemic Heart Failure with Reduced Ejection Fraction

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4144084-A4144084, November 12, 2024. Not only did EECP improve the patient's angina and functional status, but it also enhanced her cardiac function. EECP may alleviate the need for heart transplantation through its integration as a standard early intervention.