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Background In acute heartfailure (HF), reduced cardiac output, vasoconstriction and congestion may damage the intestinal mucosa and disrupt its barrier function. This could facilitate the leakage of bacterial products into circulation and contribute to inflammation and adverse cardiac remodelling.
BackgroundOral treatment with the exogenous ketone body 3hydroxybutyrate improves cardiacfunction in patients with heartfailure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Twelve patients with heartfailure with reduced ejection fraction were included. L/min (95% CI, 0.71.1
Journal of the American Heart Association, Ahead of Print. BackgroundThe purpose of this study was to investigate whether circulating pyruvate kinase M2 (PKM2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in patients with heartfailure (HF).Methods versus 7.82.3
Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiacfunction, eventually leading to heartfailure. Cardiomyocyte-specific overexpression ofIno80, its core catalytic subunit, induced heartfailure within 4 days.
Associations of colchicine-related plasma proteins, incident heartfailure (HF) and cardiac structure and function. HFpEF, heartfailure with preserved ejection fraction; HFrEF, heartfailure with reduced ejection fraction.
Circulation, Volume 150, Issue Suppl_1 , Page A4144084-A4144084, November 12, 2024. Not only did EECP improve the patient's angina and functional status, but it also enhanced her cardiacfunction. EECP may alleviate the need for heart transplantation through its integration as a standard early intervention.
Circulation, Volume 150, Issue Suppl_1 , Page A4115947-A4115947, November 12, 2024. Background:The positive effects of sodium glucose co-transporter-2 (SGLT2) inhibitors on reducing cardiovascular mortality and hospitalizations due to heartfailure have been well established.
Circulation, Volume 150, Issue Suppl_1 , Page A4139191-A4139191, November 12, 2024. Introduction:Heart failure with reduced ejection fraction (HFrEF) remains a significant clinical challenge, evidenced by high hospitalization rates and five-year mortality. Cardiacfunction was assessed by echocardiography at 2-, 4- and 6-weeks post-MI.
Circulation: HeartFailure, Ahead of Print. Background:NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heartfailure with preserved ejection fraction (HFpEF), even in the presence of increased left ventricular filling pressures.
Circulation: Cardiovascular Interventions, Ahead of Print. Background:There are limited data about changes in cardiacfunction (cardiac reverse remodeling) and heartfailure indices after transcatheter tricuspid valve-in-valve replacement (TT-VIVR).
Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Pathogenic variants in PKP2 (plakophilin-2) cause arrhythmogenic right ventricular cardiomyopathy, a disease characterized by life-threatening arrhythmias and progressive cardiomyopathy leading to heartfailure.
Circulation, Ahead of Print. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heartfailure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiacfunction in a pressure overload–induced HF model in vivo.
Circulation: HeartFailure, Volume 17, Issue 12 , Page e011729, December 1, 2024. Cardiacfunction was measured by echocardiography. In EAM, the treatment prevented deterioration of cardiacfunction, measured on day 42 post-disease induction (left ventricular ejection fraction: 56.5% versus 51.0%
Circulation, Volume 150, Issue Suppl_1 , Page A4145572-A4145572, November 12, 2024. Introduction:Dilated cardiomyopathy (DCM) is one of the causative diseases of heartfailure, caused by genetic mutations. However, the method to reduce DNA damage in the heart has not been elucidated.
Since mammals cannot regenerate cardiac muscle cells on their own, heart transplants are currently the only clinically viable option for patients suffering (or likely to suffer) heartfailure. They monitored the condition of the animals for twelve weeks, taking regular measurements of cardiacfunction.
The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should. That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An
Getty Images milla1cf Wed, 03/20/2024 - 19:16 March 20, 2024 — SARS-CoV-2 , the virus that causes COVID-19 , can damage the heart even without directly infecting the heart tissue, a National Institutes of Health -supported study has found.
Although the mineralocorticoid-receptor antagonist spironolactone, in conjunction with renin-angiotensin system (RAS) inhibitors, has been shown to reduce mortality in patients with heartfailure with reduced ejection fraction (HFrEF), its efficacy in managing degenerative MR is uncertain.
Circulation, Volume 150, Issue Suppl_1 , Page A4146466-A4146466, November 12, 2024. Background:Without timely intervention, pressure-overloading left ventricular (poLV) remodeling may become progressive and readily degenerate into heartfailure.
Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Cardiac fibrosis is a pathological hallmark of almost all forms of heart disease, characterized by excessive deposition of extracellular matrix (ECM) proteins by activated fibroblasts, leading to cardiomyocyte hypertrophy, arrhythmias, and heartfailure.
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates. Quantitative real-time polymerase chain reaction was used to detect the expression levels of miR-574-3p and cardiac hypertrophy markers.
One of these diseases is heartfailure – a condition in which the heart is unable to pump enough blood to the organs in our body. This results in a deficiency of oxygen and nutrients in the cells of the body, which can have a huge impact on how it functions. Heart Fail. Circulation 2010, 122, 2022–2030. [6]
The multisociety working group defined five outcome domains: vital status, patient-reported outcomes, progression of the disease, cardiacfunction and durability, and complications of treatment. tim.hodson Tue, 02/18/2025 - 16:41 Feb.
Circulation, Volume 150, Issue Suppl_1 , Page A4115027-A4115027, November 12, 2024. Background:The emerging field of cardiac optogenetics uses pulses of light to stimulate optically-sensitive proteins in the heart, influencing cellular physiology with unprecedented spatiotemporal resolution. cm/s (Δ 0.87
Circulation, Ahead of Print. BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing.
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