Cardiac Function, Circulation and Heart Failure

Cardiac Function

Circulation

Heart Failure

Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

OCTOBER 17, 2023

Associations of colchicine-related plasma proteins, incident heart failure (HF) and cardiac structure and function. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.

Heart Failure

Heart Failure Preserved Ejection Fraction Circulation Pharmacology

Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction

Circulation: Heart Failure

FEBRUARY 1, 2024

Circulation: Heart Failure, Ahead of Print. Background:NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heart failure with preserved ejection fraction (HFpEF), even in the presence of increased left ventricular filling pressures.

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Atrial Fibrillation Cardiac Function

Cardiac Reverse Remodeling and Changes in Heart Failure Indices After Transcatheter Tricuspid Valve Replacement in Adults With Congenital Heart Disease

Circulation: Cardiovascular Interventions

NOVEMBER 9, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. Background:There are limited data about changes in cardiac function (cardiac reverse remodeling) and heart failure indices after transcatheter tricuspid valve-in-valve replacement (TT-VIVR).

Congenital Heart Disease

Congenital Heart Disease Tricuspid Heart Failure Congenital

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Circulation

NOVEMBER 14, 2023

Circulation, Ahead of Print. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiac function in a pressure overload–induced HF model in vivo.

Heart Failure

Heart Failure Pharmacology Cardiac Function Circulation

Aerobic Exercise Attenuates Pressure Overload–Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice

Circulation: Heart Failure

FEBRUARY 27, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates. Quantitative real-time polymerase chain reaction was used to detect the expression levels of miR-574-3p and cardiac hypertrophy markers.

Exercise

Exercise Cardiac Rehabilitation Cardiac Function Heart Failure

Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction

Open Heart

SEPTEMBER 13, 2024

Background In acute heart failure (HF), reduced cardiac output, vasoconstriction and congestion may damage the intestinal mucosa and disrupt its barrier function. This could facilitate the leakage of bacterial products into circulation and contribute to inflammation and adverse cardiac remodelling.

Cardiac Function

Cardiac Function Myocardial Infarction Heart Failure STEMI

Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism

Circulation

FEBRUARY 23, 2024

Circulation, Ahead of Print. BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing.

Myocardial Infarction

Myocardial Infarction Cardiac Function Biomarkers Heart Failure

Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy

DAIC

APRIL 30, 2024

Since mammals cannot regenerate cardiac muscle cells on their own, heart transplants are currently the only clinically viable option for patients suffering (or likely to suffer) heart failure. They monitored the condition of the animals for twelve weeks, taking regular measurements of cardiac function.

Transplant

Transplant Heart Transplant Myocardial Infarction Heart Attack

USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

DAIC

DECEMBER 12, 2023

The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should. That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An

Heart Attack

Heart Attack Heart attacks Heart Disease Pharmacology

Severe Lung Infection During COVID-19 Can Cause Damage to the Heart

DAIC

MARCH 20, 2024

Getty Images milla1cf Wed, 03/20/2024 - 19:16 March 20, 2024 — SARS-CoV-2 , the virus that causes COVID-19 , can damage the heart even without directly infecting the heart tissue, a National Institutes of Health -supported study has found.

COVID-19

COVID-19 Heart Attack Heart attacks Research

INO80-Dependent Remodeling of Transcriptional Regulatory Network Underlies the Progression of Heart Failure

Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. Cardiomyocyte-specific overexpression ofIno80, its core catalytic subunit, induced heart failure within 4 days.

Heart Failure

Heart Failure Cardiac Function Circulation

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Journal of Cardiovascular Pharmacology

JULY 23, 2024

Although the mineralocorticoid-receptor antagonist spironolactone, in conjunction with renin-angiotensin system (RAS) inhibitors, has been shown to reduce mortality in patients with heart failure with reduced ejection fraction (HFrEF), its efficacy in managing degenerative MR is uncertain.

Bicuspid/Mitral

Bicuspid/Mitral Cardiac Function Heart Failure Circulation

AAV-Mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans

Circulation: Genomic and Precision Medicine

JANUARY 30, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Pathogenic variants in PKP2 (plakophilin-2) cause arrhythmogenic right ventricular cardiomyopathy, a disease characterized by life-threatening arrhythmias and progressive cardiomyopathy leading to heart failure.

Cardiomyopathy

Cardiomyopathy Arrhythmia Cardiac Function Heart Failure

Cardiac resynchronization therapy (CRT) – why is it so important?

Cardiomatics

FEBRUARY 9, 2022

One of these diseases is heart failure – a condition in which the heart is unable to pump enough blood to the organs in our body. This results in a deficiency of oxygen and nutrients in the cells of the body, which can have a huge impact on how it functions. Heart Fail. Circulation 2010, 122, 2022–2030. [6]

Heart Failure

Heart Failure Myocardial Infarction Medicare Cardiac Function

Cardiovascular Update

Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction

Cardiac Reverse Remodeling and Changes in Heart Failure Indices After Transcatheter Tricuspid Valve Replacement in Adults With Congenital Heart Disease

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

Aerobic Exercise Attenuates Pressure Overload–Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice

Intestinal fatty acid binding protein is associated with infarct size and cardiac function in acute heart failure following myocardial infarction

Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism

Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy

USF Health Heart Institute Doctors Are Upbeat about Cardiac Regeneration

Severe Lung Infection During COVID-19 Can Cause Damage to the Heart

INO80-Dependent Remodeling of Transcriptional Regulatory Network Underlies the Progression of Heart Failure

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

AAV-Mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans

Cardiac resynchronization therapy (CRT) – why is it so important?

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