Circulation

DECEMBER 28, 2023

Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure.

Heart Failure 53

Heart Failure Cardiac Function Circulation 53

Journal of the American Heart Association

FEBRUARY 14, 2025

Cardiac structural and functional changes were evaluated by echocardiography, gravimetry, and histopathological analyses. The low BCAA diet preserved stroke volume and cardiac output after MI, whereas the high BCAA diet promoted progressive decreases in cardiac function.

Diet 45

Diet Cardiac Function Myocardial Infarction Circulation 45

Circulation: Genomic and Precision Medicine

JANUARY 30, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print. Cardiac function and disease progression were monitored by survival analyses, echocardiography, and electrocardiography.RESULTS:Consistent with prior findings, loss of PKP2 expression caused 100% mortality within 50 days after tamoxifen injection.

Cardiomyopathy 72

Cardiomyopathy Arrhythmia Cardiac Function Heart Failure 72

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140489-A4140489, November 12, 2024. Outcomes analyzed included mortality, complications, cardiac function, and hospital stay.Results:Meta-analysis of 5 studies with 58,232 patients showed that off-pump CABG was associated with a slightly lower complication rate: 15% for on-pump CABG and 13.5%

Coronary Artery Bypass Graft 40

Coronary Artery Bypass Graft Cardiac Function Outcomes Hospital 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4139191-A4139191, November 12, 2024. Cardiac function was assessed by echocardiography at 2-, 4- and 6-weeks post-MI. These results highlight the potential of ETX-258 to improve cardiac function and pathogenic structural remodeling post-MI.

Myocardial Infarction 40

Myocardial Infarction Heart Failure Cardiac Function Biomarkers 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144179-A4144179, November 12, 2024. RALBP1 knockout were generated to investigate the impact of RALBP1 on cardiac function and related signaling pathways. RBC8 could significantly improve mouse cardiac function and suppress necroptosis occurrence.

Cardiac Function 40

Cardiac Function Cancer Circulation 40

European Journal of Heart Failure

MARCH 11, 2025

Abstract Aims Sodiumglucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. Empagliflozin treatment resulted in a twofold increase in circulating ketone bodies.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Circulation 40

Circulation: Heart Failure

NOVEMBER 8, 2024

Circulation: Heart Failure, Volume 17, Issue 12 , Page e011729, December 1, 2024. Cardiac function was measured by echocardiography. In EAM, the treatment prevented deterioration of cardiac function, measured on day 42 post-disease induction (left ventricular ejection fraction: 56.5% versus 51.0%

Cardiac Function 40

Cardiac Function Heart Failure Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4134796-A4134796, November 12, 2024. Introduction:Over 6 million patients (pts) present to US emergency departments annually with chest pain (CP), of which the majority are found to have no serious disease.

Chest Pain 40

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4145572-A4145572, November 12, 2024. We have previously shown that the DNA damage accumulation and the consequent activation of DDR in cardiomyocytes are the cause of cardiac function impairment. However, the method to reduce DNA damage in the heart has not been elucidated.

Cardiomyopathy 40

Cardiomyopathy Cardiac Function Heart Failure Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141340-A4141340, November 12, 2024. Hypothesis:Fbxo44 regulates cardiac aging through the RyR2-related pathway.Methods:The doxorubicin was used to established the animal models of cardiac aging in Cardiac myocyte-specific Fbxo44 knockout (CKO) and control mice.

Cardiac Function 40

Cardiac Function Ultrasound Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4134695-A4134695, November 12, 2024. To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it.

Cardiac Function 40

Cardiac Function Aortic Circulation 40

DAIC

APRIL 30, 2024

In a recent study, a Japanese research team from Shinshu University and Keio University School of Medicine , tested a new strategy for regenerative heart therapy that involves injecting ‘cardiac spheroids’ derived from HiPSCs into monkeys with myocardial infarction.

Transplant 105

Transplant Heart Transplant Myocardial Infarction Heart Attack 105

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141714-A4141714, November 12, 2024. These DAMPs activate the Stimulator of Interferon Genes pathway, which subsequently induces the release of type I interferon and other pro-inflammatory cytokines, contributing to the inflammatory microenvironment and exacerbating cardiac dysfunction.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Outcomes Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Cardiac fibrosis is a pathological hallmark of almost all forms of heart disease, characterized by excessive deposition of extracellular matrix (ECM) proteins by activated fibroblasts, leading to cardiomyocyte hypertrophy, arrhythmias, and heart failure.

Cardiac Function 40

Cardiac Function Pharmacology Innovation Heart Failure 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4115947-A4115947, November 12, 2024. Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Aortic 40

DAIC

DECEMBER 12, 2023

That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should.

Heart Attack 105

Heart Attack Heart attacks Heart Disease Pharmacology 105

DAIC

MARCH 20, 2024

The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV2-associated acute respiratory distress syndrome ( ARDS ), a serious lung condition that can be fatal.

COVID-19 105

COVID-19 Heart Attack Heart attacks Research 105

Journal of Cardiovascular Pharmacology

JULY 23, 2024

Serial echocardiography and pressure-volume loops were utilized to assess cardiac function and hemodynamics. Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins.

Bicuspid/Mitral 40

Bicuspid/Mitral Cardiac Function Heart Failure Circulation 40

Circulation: Heart Failure

FEBRUARY 27, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates. Quantitative real-time polymerase chain reaction was used to detect the expression levels of miR-574-3p and cardiac hypertrophy markers.

Exercise 40

Exercise Cardiac Rehabilitation Cardiac Function Heart Failure 40

DAIC

JANUARY 17, 2024

The study found AI was superior in assessing cardiac function in echocardiograms when compared with assessments made by sonographers. Ouyang has published nearly 100 academic research studies in medical journals such as Journal of the American College of Cardiology ( JACC ), European Heart Journal , and Circulation.

Academic 59

Academic Innovation Research Echocardiogram 59

DAIC

FEBRUARY 18, 2025

The multisociety working group defined five outcome domains: vital status, patient-reported outcomes, progression of the disease, cardiac function and durability, and complications of treatment. tim.hodson Tue, 02/18/2025 - 16:41 Feb.

Heart Valves 52

Heart Valves Quality of Life Cardiothoracic Outcomes 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142203-A4142203, November 12, 2024. Background:Donation after Circulatory Death (DCD) donor hearts are rarely utilized for transplantation following more than 30 minutes of ischemia.

Ischemia 40

Ischemia Transplant Cardiac Function Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140979-A4140979, November 12, 2024. Background:Lipid metabolic alterations are emerging as significant mechanisms in the prognosis of cardiac remodeling induced by hypertension and could impact the therapies for cardiac fibrosis.

Hypertension 40

Hypertension Transplant Cardiac Function Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4115027-A4115027, November 12, 2024. Background:The emerging field of cardiac optogenetics uses pulses of light to stimulate optically-sensitive proteins in the heart, influencing cellular physiology with unprecedented spatiotemporal resolution. cm/s (Δ 0.87

Echocardiogram 40

Echocardiogram Bicuspid/Mitral Heart Rhythm Cardiac Function 40

Circulation

FEBRUARY 23, 2024

Circulation, Ahead of Print. BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing.

Myocardial Infarction 45

Myocardial Infarction Cardiac Function Biomarkers Heart Failure 45

Circulation

OCTOBER 27, 2023

Circulation, Ahead of Print. Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and compositional changes in the extracellular matrix. Conditional knockout ofVcanin cardiac fibroblasts decreased cardiomyocyte proliferation and impaired neonatal heart regeneration.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Heart Disease Circulation 40

Circulation: Cardiovascular Interventions

NOVEMBER 9, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. Background:There are limited data about changes in cardiac function (cardiac reverse remodeling) and heart failure indices after transcatheter tricuspid valve-in-valve replacement (TT-VIVR).

Congenital Heart Disease 40

Congenital Heart Disease Tricuspid Heart Failure Congenital 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146466-A4146466, November 12, 2024. Plasma Kyn levels were clinically associated with the cardiac functions and the degree of remodeling.

Congenital Heart Disease 40

Congenital Heart Disease Heart Failure Pediatrics Transplant 40

Circulation: Heart Failure

FEBRUARY 1, 2024

Circulation: Heart Failure, Ahead of Print. Background:NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heart failure with preserved ejection fraction (HFpEF), even in the presence of increased left ventricular filling pressures.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Atrial Fibrillation Cardiac Function 40

Circulation

NOVEMBER 14, 2023

Circulation, Ahead of Print. Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. We investigated the effect of ERR agonist on cardiac function in a pressure overload–induced HF model in vivo. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heart failure (HF).

Heart Failure 40

Heart Failure Pharmacology Cardiac Function Circulation 40

Dr. Smith's ECG Blog

JULY 21, 2024

Cardiac function is poor, with akinesis of the LAD territory. Troponin T peaked at 38,398 ng/L ( = a very large myocardial infarction, but not massive-- thanks to the pre-PCI spontaneous reperfusion, and rapid internvention!! ). The echo images below were obtained on the day of presentation after PCI.

Arrhythmia 132

Arrhythmia Cardiogenic Shock Bradycardia Defibrillator 132

Cardiomatics

FEBRUARY 9, 2022

Cardiac resynchronization therapy (CRT) exists as an option for patients with heart failure with reduced ejection fraction (HFrEF), for whom pharmacotherapy alone is insufficient to reduce symptoms and control cardiac function [2]. Circulation 2010, 122, 2022–2030. [6] Heart Fail. 2012, 14, 628–634. [5] 6] Howell, S.J.;

Heart Failure 52

Heart Failure Myocardial Infarction Medicare Defibrillator 52