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Effects of weight loss after sleeve gastrectomy on left ventricular myocardial work in obese patients

Frontiers in Cardiovascular Medicine

BackgroundObesity is a global epidemic and a major risk factor for cardiovascular diseases. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery, but its effect on cardiac functions remains unclear.

Obesity 52
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CRISPR-Cas9 base editing of pathogenic CaMKII? improves cardiac function in a humanized mouse model

Journal of Clinical Investigation - Cardiology

Cardiovascular diseases are the most common cause of worldwide morbidity and mortality, highlighting the necessity for advanced therapeutic strategies. Our findings identify a potentially effective strategy for cardioprotection in response to oxidative damage.

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SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes

Cardiovascular Diabetology

Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabe.

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EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION

Journal of Cardiovascular Pharmacology

Myocardial infarction (MI) and pulmonary artery hypertension (PAH) are two prevalent cardiovascular diseases. Pterostilbene (PTE), an antioxidant compound, has been studied as a possible therapy for cardiovascular diseases. PTE also improved cardiac function in infarcted rats and pulmonary artery flow in animals with PAH.

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Relationship Between RNF213 p.R4810K and Echocardiographic Findings in Patients with Cerebrovascular Diseases: A Multicenter Prospective Cohort Study

Journal of the American Heart Association

BackgroundRING finger protein 213 (RNF213) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension.

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The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study

Journal of the American Heart Association

BackgroundChronic lead exposure is associated with both subclinical and clinical cardiovascular disease. Blood pressure and measures of cardiac geometry and function were obtained in 2001 to 2003 and 2006 to 2009. Journal of the American Heart Association, Ahead of Print. Mean blood lead was 2.04 μg/dL at baseline.

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Canonical Transient Receptor Potential (TRPC) Channels in Cardiovascular Pathology and their Modulators

Journal of Cardiovascular Pharmacology

Ion channels play a crucial role in various aspects of cardiac function, such as regulating rhythm and contractility. As a result, they serve as key targets for therapeutic interventions in cardiovascular diseases. As a result, they serve as key targets for therapeutic interventions in cardiovascular diseases.