Cardiovascular Diabetology

NOVEMBER 25, 2024

Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication of diabetes characterized by myocardial hypertrophy, fibrosis, and impaired cardiac function. Fibroblast growth factor 21 (FGF21) has emerg.

Cardiomyopathy 98

Cardiomyopathy Diabetes Cardiac Function 98

American College of Cardiology

DECEMBER 10, 2024

How do N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-CTnI) predict long-term changes in cardiac structure and function in older adults?

Cardiac Function 52

Cardiac Function Article 52

Medical Xpress - Cardiology

JANUARY 11, 2024

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors. Data from the St. Jude lifetime cohort study (St.

Biomarkers 116

Biomarkers Cancer Cardiac Function Cardiomyopathy 116

JAMA Cardiology

NOVEMBER 14, 2023

This post hoc analysis of the randomized Tafamidis in Transthyretin Cardiomyopathy Clinical Trial examines the effect of tafamidis vs placebo on 30-month changes in cardiac function in patients with transthyretin amyloid cardiomyopathy.

Cardiac Function 40

Cardiac Function Cardiomyopathy 40

Journal of the American Heart Association

JANUARY 16, 2025

U/mL,P<0.001), and these levels correlated with HF severity (New York Heart Association cardiac function class). Patients with HF had higher PKM2 levels than controls (17.44.1 versus 7.82.3 Patients with reduced left ventricular ejection fraction had higher PKM2 concentrations than those with preserved ejection fraction (18.34.5

Cardiac Function 45

Cardiac Function Heart Failure Biomarkers Preserved Ejection Fraction 45

Medical Xpress - Cardiology

DECEMBER 10, 2024

The therapy increases the amount of blood the heart can pump and dramatically improves survival, in what a paper describing the results calls "an unprecedented recovery of cardiac function."

Heart Failure 97

Heart Failure Cardiac Function 97

Frontiers in Cardiovascular Medicine

MARCH 26, 2024

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

Cardiac Function 64

Cardiac Function Aortic Stroke Strokes 64

HeartRhythm

APRIL 30, 2024

Catheter ablation is recommended in patients with suspected atrial fibrillation-mediated cardiomyopathy (AMC) for the recovery of cardiac function.

Atrial Fibrillation 40

Atrial Fibrillation Cardiac Function Cardiomyopathy Ablation 40

Circulation

NOVEMBER 11, 2024

addition, its robust performance suggests a strong potential for widespread adoption in routine cardiac evaluations. Our approach provides rapid, accurate assessments of LVID makes it an invaluable tool for cardiac function evaluation.

Cardiac Function 40

Cardiac Function Pediatrics Echocardiogram Circulation 40

Medical Xpress - Cardiology

JANUARY 19, 2024

The study, published in the journal Science Advances, identifies the first therapeutic target that can be modulated to preserve cardiac function in pulmonary hypertension, providing hope in the fight against this rare but fatal disease for which there is currently no cure.

Pulmonary 101

Pulmonary Hypertension Cardiac Function Research 101

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

The patient required prolonged catecholamine support owing to poor cardiac function, and heart transplantation was considered. Case presentation A 43-year-old man with a body mass index of 41 kg/m 2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy.

Heart Failure 124

Heart Failure Obesity Heart Transplant Transplant 124

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

CAMK2D-edited mice recovered cardiac function, showed improved exercise performance, and were protected from myocardial fibrosis, which was otherwise observed in injured control mice after IR. Our findings identify a potentially effective strategy for cardioprotection in response to oxidative damage.

Cardiac Function 40

Cardiac Function Ischemia Exercise Cardiovascular Disease 40

Cardiovascular Diabetology

NOVEMBER 4, 2024

Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in ag.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Cardiac Function Heart Dysfunction Heart Failure 52

HCPLive

MARCH 14, 2024

The AccuCinch® System, utilized by Allegheny General Hospital, offers a breakthrough approach to treating heart failure by targeting the left ventricle.

Quality of Life 52

Quality of Life Heart Failure Cardiac Function Innovation 52

Frontiers in Cardiovascular Medicine

JANUARY 20, 2025

Despite its known effects on cholesterol metabolism, the role of PCSK9 in cardiac function, especially post-myocardial infarction (MI), remains unclear. Cardiac function was assessed via echocardiography and isolated working heart model experiments. PCSK9 and LDL receptor levels were measured using ELISA and qRT-PCR.

Myocardial Infarction 52

Myocardial Infarction Cardiac Function Cholesterol Pharmacology 52

Cardiovascular Diabetology

AUGUST 7, 2024

We sought to explore the underlying mechanisms in terms of structural and functional remodelling in HCM pati. The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood.

Cardiomyopathy 52

Cardiomyopathy Diabetes Cardiac Function Research 52

HeartRhythm

NOVEMBER 26, 2024

Mavacamten is a selective, allosteric, and reversible cardiac myosin inhibitor, representing the first disease-specific treatment for obstructive hypertrophic cardiomyopathy (HCM) that targets the core pathophysiological mechanism of this condition.

Cardiac Function 75

Cardiac Function Cardiomyopathy 75

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

Before enrollment, the patients’ left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), N-terminal pro-B-type natriuretic peptide (NT-proBNP), liver and kidney function electrolytes, and Minnesota Living with Heart Failure Questionnaire (MLHFQ) and other indicators were measured.

Heart Failure 52

Heart Failure Preserved Ejection Fraction Cardiac Function Quality of Life 52

American College of Cardiology

DECEMBER 4, 2024

Are plasma factor XI levels associated with cardiovascular events and cardiac function in humans?

Cardiac Function 56

Cardiac Function Article 56

Frontiers in Cardiovascular Medicine

JANUARY 15, 2025

It is characterized by left ventricular hypertrophy and impaired cardiac function, with forms categorized into obstructive (oHCM) and nonobstructive (nHCM). IntroductionHypertrophic cardiomyopathy (HCM) is a common genetic heart disorder. Further research is needed to confirm long-term benefits.

Cardiomyopathy 52

Cardiomyopathy Cardiac Function Research Outcomes 52

HeartRhythm

APRIL 30, 2024

Whether and how STIM1 expression in cardiomyocytes (CM) impacts cardiac remodeling in response to I/R injury is unclear. Loss of stromal interaction molecule 1 (STIM1) expression in smooth muscle cells protects against ischemia reperfusion (I/R) injury.

Cardiac Function 40

Cardiac Function Ischemia 40

Cardiovascular Diabetology

DECEMBER 3, 2024

Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabe.

Cardiac Function 52

Cardiac Function Risk Factors Cardiovascular Disease Diabetes 52

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

At baseline, cKO mice exhibited a reduced cardiac function, elevated stress markers and a decrease in FAO and GO gene expression compared to WT mice. LVH resulted in increased cardiac remodeling and a decreased expression of FAO and GO genes, but a comparable decline in cardiac function in cKO compared to WT mice.

Heart Failure 59

Heart Failure Cardiac Function Aortic 59

HCPLive

DECEMBER 12, 2023

Presented at ASH 2023, findings of a new study showed patients with sickle cell disease and venous thromboembolism have longitudinal worsening of left ventricular diastolic and right-sided cardiac function.

Sickle Cell Disease 52

Sickle Cell Disease Cardiac Function 52

DAIC

JUNE 7, 2024

In CAVD, microcrystals of hydroxyapatite (a calcium phosphate mineral) deposit onto the heart valve leaflets and impair cardiac function. The disease has a dismal prognosis with most untreated patients dying two years after diagnosis.

Aortic valve 105

Aortic valve Aortic Heart Valves Pharmacology 105

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2023

The secondary outcomes were changes in hemodynamic and cardiac function. As adjuvants to etomidate induction, they do not impair cardiac function (ChiCTR1900028030). Results The incidence of the response to cardiovascular stress was 23.1%, 30.8%, and 65.4% in groups A, B, and C, respectively. Discussion Esketamine 0.5 mg/kg

Cardiac Function 64

Cardiac Function Outcomes Stroke Strokes 64

European Journal of Heart Failure

DECEMBER 19, 2024

This placebo-controlled study investigates whether IA/IgG treatment enhances left ventricular (LV) systolic function as compared to a control group receiving pseudo-treatment.

Cardiac Function 40

Cardiac Function Cardiomyopathy Heart Failure Outcomes 40

Dr. Smith's ECG Blog

JUNE 9, 2024

Here is the transesophageal echo (TEE) at the same time as this 2nd ECG: Excellent LV Function. I have had many cases of severe Hyperkalemia with wide complex that show good cardiac function. How could that be with such a 12-lead? The ECG above is bizarrely wide. It is nearly a sine wave.

Cardiac Arrest 103

Cardiac Arrest Defibrillator Cardiac Function Tachycardia 103

Circulation

NOVEMBER 11, 2024

Outcomes analyzed included mortality, complications, cardiac function, and hospital stay.Results:Meta-analysis of 5 studies with 58,232 patients showed that off-pump CABG was associated with a slightly lower complication rate: 15% for on-pump CABG and 13.5% The optimal approach remains debated. 1.19) and 1.15 (95% CI: 1.10-1.20),

Coronary Artery Bypass Graft 40

Coronary Artery Bypass Graft Cardiac Function Outcomes Hospital 40

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2024

Despite cardiac MRI being unsuggestive of myocarditis, myocardial biopsies were obtained and histologically confirmed anti-PD-1 antibody-associated myocarditis. After the initiation of prednisone at 1 mg/kg body weight, the patient gradually recovered and was discharged three weeks later with markedly improved cardiac function.

Cardiac Arrest 72

Cardiac Arrest Hospital Cancer Cardiac Function 72

Circulation

NOVEMBER 11, 2024

RALBP1 knockout were generated to investigate the impact of RALBP1 on cardiac function and related signaling pathways. RALBP1 knockout significantly improved cardiac function, reduced arginylation reaction, inhibition of MAM-CAMKIIδ pathway activation in ICIAM mice.

Cardiac Function 40

Cardiac Function Cancer Circulation 40

Circulation

DECEMBER 28, 2023

BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. Circulation, Ahead of Print.

Heart Failure 53

Heart Failure Cardiac Function Circulation 53

Journal of the American Heart Association

JANUARY 11, 2024

Blood pressure and measures of cardiac geometry and function were obtained in 2001 to 2003 and 2006 to 2009. We used generalized estimating equations to evaluate the association of declines in blood lead with changes in blood pressure; cardiac function and geometry measures were considered secondary. μg/dL at baseline.

Blood Pressure 81

Blood Pressure Cardiac Function Cardiovascular Disease 81

DAIC

MAY 2, 2024

The team of investigators built a dataset of 1,032,975 cardiac ultrasound videos and corresponding expert interpretations to develop EchoCLIP. Key takeaways from the study include: EchoCLIP displayed strong performance when assessing cardiac function using heart images.

Echocardiogram 101

Echocardiogram Ultrasound Aortic valve Bicuspid/Mitral 101

Journal of the American Heart Association

FEBRUARY 29, 2024

Our purpose is to investigate the effect of MYPT2 on cardiac function and fibrosis in mineralocorticoid receptor‐related hypertension.Methods and ResultsHL‐1 murine cardiomyocytes were incubated with different concentrations or durations of aldosterone.

Hypertension 75

Hypertension Blood Pressure Cardiac Function 75

Journal of Cardiovascular Electrophysiology

NOVEMBER 5, 2024

Abstract Introduction This case report highlights the novel role of His-bundle pacing (HBP) from right atrium, not just for preserving cardiac function, but also for avoiding interference with TriClip devices. Conclusion HBP is effective for patients with TriClip devices, ensuring optimal cardiac function and lead stability.

Pacemaker 40

Pacemaker Cardiac Function Tricuspid 40

Clinical Trial Results

APRIL 7, 2024

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