Medical Xpress - Cardiology

MARCH 28, 2024

Magnesium is a mineral critical to a wide range of biological functions, and a new study takes aim at how it's transported to address cardiac dysfunction and other diseases, opening new possibilities for treatment.

Cardiac Function 104

Cardiac Function Research 104

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

CAMK2D-edited mice recovered cardiac function, showed improved exercise performance, and were protected from myocardial fibrosis, which was otherwise observed in injured control mice after IR. Our findings identify a potentially effective strategy for cardioprotection in response to oxidative damage.

Cardiac Function 40

Cardiac Function Ischemia Exercise Cardiovascular Disease 40

Medical Xpress - Cardiology

JANUARY 10, 2024

Inflammation of the heart muscle, also known as myocarditis, is a serious consequence of a viral infection. This can impede the heart's ability to pump blood in the long term. In a recent study, researchers of the Faculty of Medicine of the University of Freiburg have discovered a new approach for treating myocarditis.

Cardiac Function 63

Cardiac Function Research 63

Cardiovascular Diabetology

AUGUST 7, 2024

We sought to explore the underlying mechanisms in terms of structural and functional remodelling in HCM pati. The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood.

Cardiomyopathy 52

Cardiomyopathy Diabetes Cardiac Function Research 52

Frontiers in Cardiovascular Medicine

MARCH 26, 2024

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

Cardiac Function 64

Cardiac Function Aortic Strokes Stroke 64

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

Before enrollment, the patients’ left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), N-terminal pro-B-type natriuretic peptide (NT-proBNP), liver and kidney function electrolytes, and Minnesota Living with Heart Failure Questionnaire (MLHFQ) and other indicators were measured.

Heart Failure 52

Heart Failure Preserved Ejection Fraction Cardiac Function Quality of Life 52

HCPLive

MARCH 14, 2024

The AccuCinch® System, utilized by Allegheny General Hospital, offers a breakthrough approach to treating heart failure by targeting the left ventricle.

Quality of Life 52

Quality of Life Heart Failure Cardiac Function Innovation 52

Circulation

NOVEMBER 11, 2024

Outcomes analyzed included mortality, complications, cardiac function, and hospital stay.Results:Meta-analysis of 5 studies with 58,232 patients showed that off-pump CABG was associated with a slightly lower complication rate: 15% for on-pump CABG and 13.5% The optimal approach remains debated. 1.19) and 1.15 (95% CI: 1.10-1.20),

Coronary Artery Bypass Graft 40

Coronary Artery Bypass Graft Cardiac Function Outcomes Hospital 40

Circulation

NOVEMBER 11, 2024

RALBP1 knockout were generated to investigate the impact of RALBP1 on cardiac function and related signaling pathways. RALBP1 knockout significantly improved cardiac function, reduced arginylation reaction, inhibition of MAM-CAMKIIδ pathway activation in ICIAM mice.

Cardiac Function 40

Cardiac Function Cancer Circulation 40

HeartRhythm

APRIL 30, 2024

Whether and how STIM1 expression in cardiomyocytes (CM) impacts cardiac remodeling in response to I/R injury is unclear. Loss of stromal interaction molecule 1 (STIM1) expression in smooth muscle cells protects against ischemia reperfusion (I/R) injury.

Cardiac Function 40

Cardiac Function Ischemia 40

Medical Xpress - Cardiology

JANUARY 11, 2024

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors. Data from the St. Jude lifetime cohort study (St.

Biomarkers 111

Biomarkers Cancer Cardiac Function Cardiomyopathy 111

Circulation

NOVEMBER 11, 2024

Cardiac function was assessed by echocardiography at 2-, 4- and 6-weeks post-MI. Cardiac damage and structural remodeling were evaluated using circulating biomarkers of cardiac function and histological assessment.Results:ETX-258 was selected as a highly active siRNA for the treatment of heart failure with a long duration of action.

Myocardial Infarction 40

Myocardial Infarction Heart Failure Cardiac Function Biomarkers 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4134796-A4134796, November 12, 2024. Introduction:Over 6 million patients (pts) present to US emergency departments annually with chest pain (CP), of which the majority are found to have no serious disease.

Chest Pain 40

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease 40

Medical Xpress - Cardiology

JANUARY 19, 2024

The study, published in the journal Science Advances, identifies the first therapeutic target that can be modulated to preserve cardiac function in pulmonary hypertension, providing hope in the fight against this rare but fatal disease for which there is currently no cure.

Pulmonary 89

Pulmonary Hypertension Cardiac Function Research 89

Circulation

NOVEMBER 11, 2024

We have previously shown that the DNA damage accumulation and the consequent activation of DDR in cardiomyocytes are the cause of cardiac function impairment. Cases with mutations in theLMNAgene, which encodes lamin A/C protein and constitutes the nuclear lamina, are known to have a poor prognosis.

Cardiomyopathy 40

Cardiomyopathy Cardiac Function Heart Failure Circulation 40

Circulation

NOVEMBER 11, 2024

Hypothesis:Fbxo44 regulates cardiac aging through the RyR2-related pathway.Methods:The doxorubicin was used to established the animal models of cardiac aging in Cardiac myocyte-specific Fbxo44 knockout (CKO) and control mice. Cardiac function of mice was assessed using Doppler ultrasound.

Cardiac Function 40

Cardiac Function Ultrasound Circulation 40

Circulation

NOVEMBER 11, 2024

To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it. Cardiomyocyte-specific deletion of LDHA also led to a reduction in cardiac hypertrophy.

Cardiac Function 40

Cardiac Function Aortic Circulation 40

HCPLive

DECEMBER 12, 2023

Presented at ASH 2023, findings of a new study showed patients with sickle cell disease and venous thromboembolism have longitudinal worsening of left ventricular diastolic and right-sided cardiac function.

Sickle Cell Disease 52

Sickle Cell Disease Cardiac Function 52

Circulation

NOVEMBER 11, 2024

Mice were treated with curcumin, and cardiac function was assessed by echocardiography. Post-myocardial infarction, macrophages were isolated and subjected to RNA-Seq analysis, which revealed that IFNβ1 was the most significantly downregulated transcription factor.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Outcomes Circulation 40

Circulation

NOVEMBER 11, 2024

We hypothesize that hPSC-derived CAR-neutrophils engineered to target FAP will effectively reduce cardiac fibrosis and improve cardiac function post-injury due to their potent cytotoxic effects and ability to infiltrate infarct regions.

Cardiac Function 40

Cardiac Function Pharmacology Innovation Heart Failure 40

Circulation

NOVEMBER 11, 2024

Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Aortic 40

HeartRhythm

APRIL 30, 2024

Cardiac Contractility Modulation (CCM) is a non-excitatory electrical stimulation for improving cardiac function. However, the effect of CCM on metabolic remodeling of heart failure is unknown.

Heart Failure 40

Heart Failure Cardiac Function 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

At baseline, cKO mice exhibited a reduced cardiac function, elevated stress markers and a decrease in FAO and GO gene expression compared to WT mice. LVH resulted in increased cardiac remodeling and a decreased expression of FAO and GO genes, but a comparable decline in cardiac function in cKO compared to WT mice.

Heart Failure 59

Heart Failure Cardiac Function Aortic 59

Frontiers in Cardiovascular Medicine

APRIL 7, 2024

In these patients, congenital defects themselves, surgical operations and remaining lesions may alter cardiac anatomy and impact the mechanical performance of both ventricles. Cardiac function significantly influences outcomes in CHDs, necessitating regular patient follow-up to detect clinical changes and relevant risk factors.

Congenital Heart Disease 40

Congenital Heart Disease Congenital Heart Disease Anatomy 40

HeartRhythm

APRIL 30, 2024

Einthoven's and Goldberger's lead systems are the basis of electrocardiography, providing insights into cardiac function and heart health. Despite their long-standing use, the new landscape of technology and lack of current validation of these systems require a re-evaluation.

Cardiac Function 40

Cardiac Function Technology 40

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

The patient required prolonged catecholamine support owing to poor cardiac function, and heart transplantation was considered. Case presentation A 43-year-old man with a body mass index of 41 kg/m 2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy.

Heart Failure 124

Heart Failure Obesity Heart Transplant Transplant 124

Journal of Cardiovascular Pharmacology

FEBRUARY 11, 2024

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared to wild-type mice at day 28 post-MI.

Cardiac Function 40

Cardiac Function Myocardial Infarction Article 40

Nature Reviews - Cardiology

JUNE 4, 2024

Nature Reviews Cardiology, Published online: 05 June 2024; doi:10.1038/s41569-024-01048-4 Milda Folkmanaite and Manuela Zaccolo highlight a study that demonstrates a role for phase-separated condensates of protein kinase A in buffering molecules of cAMP, to illustrate how phase separation of proteins in cardiac cells might contribute to the regulation (..)

Cardiac Function 40

Cardiac Function 40

Journal of Cardiovascular Pharmacology

OCTOBER 14, 2024

Ion channels play a crucial role in various aspects of cardiac function, such as regulating rhythm and contractility. Cell function is substantially influenced by the concentration of free cytosolic calcium (Ca2+) and the voltage across the plasma membrane.

Cardiovascular Disease 40

Cardiovascular Disease Cardiac Function Article Physiology 40

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Moreover, blocking chemokine CXCR2 to inhibit the specification of the S100a9+Ly6c+-biased inflammatory fate in P10 hearts resulted in elevated wound repair responses and marked improvements in cardiac function after injury.

Myocardial Infarction 52

Myocardial Infarction Cardiac Function 52

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2023

The secondary outcomes were changes in hemodynamic and cardiac function. As adjuvants to etomidate induction, they do not impair cardiac function (ChiCTR1900028030). Results The incidence of the response to cardiovascular stress was 23.1%, 30.8%, and 65.4% in groups A, B, and C, respectively. Discussion Esketamine 0.5 mg/kg

Cardiac Function 64

Cardiac Function Outcomes Strokes Stroke 64

Clinical Trial Results

APRIL 7, 2024

Loading… Taking too long? Reload document | Open in new tab Download [958.21 KB] Disclosures: TBD

Download 40

Download Cardiac Function Document Cardiomyopathy 40

Circulation

DECEMBER 28, 2023

BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. Circulation, Ahead of Print.

Heart Failure 53

Heart Failure Cardiac Function Circulation 53

HeartRhythm

JUNE 4, 2024

1 It allows individuals to play a more active role in their health care, improving understanding of cardiac function and its pathologies among individuals with and without cardiac disease.2 2 However, risk of misdiagnoses exists.3,4

Atrial Fibrillation 40

Atrial Fibrillation Electrocardiogram Cardiac Function 40

Frontiers in Cardiovascular Medicine

OCTOBER 7, 2024

ConclusionsThis research presents evidence of a potential causal association between traits of SLE and alterations in cardiac function, guiding cardiac examinations and disease prevention in lupus patients.

Cardiac Function 59

Cardiac Function Aortic Heart Disease Research 59

HeartRhythm

JANUARY 29, 2024

Mitochondria control cardiac function by regulating adenosine triphosphate synthesis, reactive oxygen species (ROS) generation, intracellular calcium (Ca2+), and the cellular redox state. Yet, their role in the pathophysiology of arrhythmias remains massively underappreciated.

Arrhythmia 40

Arrhythmia Cardiac Function Article 40

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

Cardiac function was measured by echocardiography during hospitalization and follow-up. Major adverse cardiac events (MACEs) were recorded for prognostic analysis. Results At the 6-month follow-up, AMI patients who received TPE after primary PCI had significantly lower levels of CTCF (24.27 ± 2.40

Myocardial Infarction 59

Myocardial Infarction Outcomes Cardiac Function Thrombolysis 59