Remove Cardiac Arrest Remove Pediatrics Remove Sudden Cardiac Death
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Brugada Syndrome: Diagnosis and Risk Stratification

All About Cardiovascular System and Disorders

Brugada syndrome is thought to account for about one fourth of sudden cardiac deaths in individuals with structurally normal heart. It is seldom done in pediatric age group. Yet, SCN5A variants are identified in only about one fifth of persons with Brugada syndrome. With proper precautions, risk can be reduced.

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A man in his 70s with weakness and syncope

Dr. Smith's ECG Blog

This discussion comes from this previous post: Hyperthermia and ST Elevation Discussion Brugada Type 1 ECG changes are associated with sudden cardiac death (SCD) and the occurrence of ventricular dysrhythmias. Pediatric and elderly patients were more predisposed to developing an arrhythmic event in the setting of fever [7].

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Hyperthermia and ST Elevation

Dr. Smith's ECG Blog

The limb lead abnormalities appear to be part of the Brugada pattern, as described in this article: Inferior and Lateral Electrocardiographic RepolarizationAbnormalities in Brugada Syndrome Discussion Brugada Type 1 ECG changes are associated with sudden cardiac death (SCD) and the occurrence of ventricular dysrhythmias.

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QT Correction Formulas Compared to The Rule of Thumb ("Half the RR")

Dr. Smith's ECG Blog

However, according to these diagnostic criteria (JACC 2011; 57(7):802), it is a Bazett corrected QT of less than 330-370, depending on other diagnostic criteria, including 1) h/o cardiac arrest, 2) sudden syncope, 3) family hx of sudden unexplained arrest at age less than 40, 4) family hx of SQTS.

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Independent External Evaluation of Pediatric Hypertrophic Cardiomyopathy Risk Scores in Predicting Severe Ventricular Arrhythmias

Circulation: Arrhythmia and Electrophysiology

BACKGROUND:Sudden cardiac death is the most common cause of death in childhood hypertrophic cardiomyopathy (HCM). Recently, 2 risk scores have been developed to estimate the 5-year risk of sudden cardiac death. HCM Risk-Kids and PRIMaCY risk scores were calculated at diagnosis and during follow-up.

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A young F is hyperthermic, delirious, and dry: Fever-induced Brugada? Diphenhydramine toxicity? Tricyclic?

Dr. Smith's ECG Blog

Further history later: This patient personally has no further high risk features (syncope / presyncope), but her mother had sudden cardiac arrest in sleep. Twenty-one percent (18 of 88) had a family history of sudden cardiac death and 26.4% (14 of 53) carried a pathogenic SCN5A mutation.