Physiologically Speaking

JANUARY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. COSMOS tested a cocoa extract supplement and a multivitamin-mineral supplement against one another and a placebo for reducing the risk of cardiovascular disease and cancer.

Physiology 52

Physiology Diet Cardiovascular Disease BMI 52

Journal of Cardiothoracic Surgery

DECEMBER 7, 2023

Frailty develops as a result of age-related decline in many physiological systems and is associated with increased vulnerability to adverse outcomes following thoracic surgery. We prospectively tested our hypo.

Cancer 40

Cancer Physiology Pulmonary Outcomes 40

Heart BMJ

MAY 10, 2024

HF affects around a million people in the UK and has a worse prognosis than most cancers. In this article, we will review the physiology of NPs and study their biological effects. While progress has been made in the management of most aspects of cardiovascular disease, the incidence and prevalence of heart failure (HF) remains high.

Biomarkers 52

Biomarkers Heart Failure Physiology Article 52

Physiologically Speaking

DECEMBER 20, 2023

Physiologically Speaking is a reader-supported publication. Physiologically Speaking is a reader-supported publication. After some time, we began to talk about research into TOR kinases (Jack was quick to point out that much of contemporary cancer research has moved to immune checkpoint inhibitors). ” Sounds good, right?

Cancer 52

Cancer Physiology Research Laboratory 52

Hypertension Journal

DECEMBER 7, 2023

ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. Hypertension, Ahead of Print.

Kidney Disease 45

Kidney Disease Hypertension Pulmonary Atherosclerosis 45

Circulation

NOVEMBER 11, 2024

While each device has a different physiological impact on the heart, limited studies compare genetic changes in the heart t-MCS. 1C) of the downregulated miRs exhibited a regulatory role in inflammatory and cancer-based genes. and 4 bridged with IABP. Results:The top upregulated (Fig. 1A) and downregulated (Fig. UpSet plots (Fig.

Cardiogenic Shock 40

Cardiogenic Shock Cancer Heart Failure Physiology 40

Physiologically Speaking

OCTOBER 9, 2024

Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. Physiologically Speaking is a reader-supported publication. LaKe is an ester composed of (S)-lactate and (R)-1,3-butanediol, a precursor to BHB.

Exercise 75

Exercise Physiology Diet Obesity 75

Journal of the American Heart Association

NOVEMBER 28, 2023

BackgroundSingle‐cell RNA sequencing is widely used in cancer research and organ development because of its powerful ability to analyze cellular heterogeneity. Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023.

Pacemaker 40

Pacemaker Physiology Cancer Research 40

Journal of Cardiovascular Pharmacology

OCTOBER 14, 2024

TRPC channels are multidimensional signalling protein complexes that play essential roles in a variety of physiological and pathological processes in humans, including cancer, neurological disorders, cardiovascular diseases, and others.

Cardiovascular Disease 40

Cardiovascular Disease Cardiac Function Article Physiology 40

Dr. Smith's ECG Blog

MARCH 15, 2021

An 80-something year old man with history of metastatic cancer had acute onset of chest pain and called 911. Here was his cardiac echo (remember, done 9 hours after the one above): Pericardial Effusion with Tamponade physiology, developed within 9 hours. Here is his prehospital ECG: What do you think?

Chest Pain 40

Chest Pain Ultrasound Pericarditis STEMI 40

Circulation

NOVEMBER 11, 2024

Introduction:During natural aging, physiological remodeling of the heart is a critical for the cardiovascular disease and heart failure. miR-30a-5p is related to kidney injury, cancer, and autoimmune diseases. Circulation, Volume 150, Issue Suppl_1 , Page A4139176-A4139176, November 12, 2024.

Physiology 40

Physiology Cancer Heart Failure Cardiovascular Disease 40

Physiologically Speaking

SEPTEMBER 20, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What physiological mechanisms make moderate to high levels of activity so favorable, especially in our modern environment? This week, I’m sharing one of my favorite articles I’ve ever written.

Exercise 114

Exercise Physiology Blood Pressure Obesity 114

Physiologically Speaking

MAY 1, 2024

This dietary approach has been studied for weight loss, metabolic syndrome, type 2 diabetes, epilepsy, Alzheimer’s disease, and cancer. Burke - 2021 - The Journal of Physiology - Wiley Online Library Let’s transition to discussing how exogenous ketones impact metabolism and fuel use during exercise.

Diet 52

Diet Exercise Physiology Cancer 52

Physiologically Speaking

SEPTEMBER 6, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Diabetes, cardiovascular disease, cancer, Alzheimer’s disease, depression. Thanks to the premium sponsor of this newsletter: FSTFUEL electrolyte supplement. It’s a zero-sugar electrolyte drink that tastes awesome.

Physiology 111

Physiology Exercise Research Diabetes 111

Physiologically Speaking

OCTOBER 18, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Research has linked circadian rhythm disruptions to a wide range of health issues, including cardiovascular disease, diabetes, obesity, and even certain cancers.

Physiology 64

Physiology Diet Research Exercise 64

Dr. Paddy Barrett

AUGUST 23, 2024

While I have covered many of these fitness measures individually in previous posts, I wanted to summarise these metrics and how they relate to living longer and preventing major diseases such as cardiovascular disease, cancer and dementia. A higher daily step count is also linked to significantly lower cancer, stroke and heart disease rates.

Exercise 116

Exercise Dementia Cancer Chronic Disease 116

Physiologically Speaking

DECEMBER 13, 2023

Physiologically Speaking is a reader-supported publication. Researchers understood its unique role in eukaryotic cell growth, and the implications it had for cancer research, aging, and diseases immediately became apparent. Harnessing this switch may prove crucial to treating cancer, immune disorders, and longevity in animals.

Cancer 52

Cancer Research Physiology 52

Physiologically Speaking

DECEMBER 13, 2023

Physiologically Speaking is a reader-supported publication. Researchers understood its unique role in eukaryotic cell growth, and the implications it had for cancer research, aging, and diseases immediately became apparent. Harnessing this switch may prove crucial to treating cancer, immune disorders, and longevity in animals.

Cancer 52

Cancer Research Physiology 52

Physiologically Speaking

MARCH 20, 2024

cardiovascular disease and cancer) mortality. regarding demographic, socioeconomic, dietary, and health-related factors collected via surveys and physiological measurements/lab tests. Adults with cardiovascular disease and cancer had a 107% and 204% greater risk, respectively, when they had an 8-hour eating window.

Diet 119

Diet Cardiovascular Disease Cancer Research 119

Physiologically Speaking

OCTOBER 16, 2024

Physiologically Speaking is a reader-supported publication. heart disease, cancer treatments). And even if we can live to 150, should we? As researchers make strides in understanding the biology of aging, these questions will continue to shape the longevity debate.

Research 72

Research Technology Public Health Physiology 72

Physiologically Speaking

FEBRUARY 26, 2024

Physiologically Speaking is a reader-supported publication. Even cancer is rare. Physiologically Speaking is a reader-supported publication. Michael Easter calls this the Scarcity Loop, and it’s the ultimate behavior loop for pushing us into behaviors we repeat — eventually to our detriment. More on these later.

Diet 52

Diet Cardiovascular Disease Exercise Research 52

Dr. Paddy Barrett

OCTOBER 24, 2023

Not everyone who meets the criteria for metabolic syndrome will become diabetic, but falling into this category means you share much of the same underlying physiology. Share Why you die earlier is likely down to the earlier onset of the two major diseases that are the leading causes of death worldwide: Cardiovascular Disease Cancer.

Diabetes 52

Diabetes Cancer Exercise Cardiovascular Disease 52

Journal of Clinical Investigation - Cardiology

MARCH 17, 2025

Protein arginine methyl transferases (PRMTs) are generally upregulated in cancers. Here, we identify PRMT5, the main symmetric arginine methyltransferase, as a critical driver of chemoresistance in high-grade serous ovarian cancer (HGSOC).

Cancer 40

Cancer Physiology 40