Journal of Clinical Investigation - Cardiology

SEPTEMBER 17, 2024

BACKGROUND Metastatic hormone-sensitive prostate cancer (mHSPC) is androgen dependent, and its treatment includes androgen deprivation therapy (ADT) with gonadal testosterone suppression.

Cancer 75

Cancer Pharmacology Physiology Outcomes 75

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Crosstalk between different types of ubiquitination results in distinct biological outcomes for proteins. Using high-throughput sequencing, we found that ubiquitin-conjugating enzyme E2 C (UBE2C) was overexpressed in bladder cancer (BCa) and was strongly associated with an unfavorable prognosis.

Cancer 96

Cancer Outcomes 96

HCPLive

JANUARY 5, 2024

Patients with lean NAFLD had fewer metabolic comorbidities but maintained similar risk of NASH, cirrhosis, nonliver cancer, and mortality compared to their overweight and obese counterparts.

BMI 105

BMI Obesity Cancer Outcomes 105

Journal of Cardiothoracic Surgery

FEBRUARY 3, 2024

Early-stage esophageal cancer is treated using endoscopic submucosal dissection and esophagectomy. Field cancerization in patients with early-stage esophageal cancer affects treatment outcomes and causes synch.

Cancer 52

Cancer Outcomes Research 52

Journal of Cardiothoracic Surgery

JUNE 21, 2024

The question of whether segmentectomy and lobectomy have similar survival outcomes for patients with early-stage non-small cell lung cancer (NSCLC) is a matter of debate.

Cancer 52

Cancer Outcomes 52

Society of Thoracic Surgeons - Surgeon

OCTOBER 15, 2024

The esophagectomy for cancer risk calculator is powered by enhanced STS esophagectomy for cancer risk models using data from 18,503 patients across 254 hospitals between January 2015 and December 2022. Key updates include the incorporation of new risk factors such as preoperative cancer staging and body surface area.

Cancer 52

Cancer Risk Factors Hospital Research 52

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Obesity is a known driver of endometrial cancer. In this issue of the JCI, Gómez-Banoy and colleagues investigated a cohort of patients with advanced endometrial cancer treated with immune checkpoint inhibitors targeting the interaction between programmed cell death receptor-1 (PD-1) and its ligand (PD-L1).

Cancer 63

Cancer Obesity BMI Biomarkers 63

Society of Thoracic Surgeons - Surgeon

OCTOBER 16, 2024

Resource Pulmonary Resection for Lung Cancer Risk Calculator gmckinney Wed, 10/16/2024 - 07:59 The new pulmonary resection for lung cancer risk calculator is engineered using contemporary data from the STS General Thoracic Surgery Database.

Cancer 52

Cancer Pulmonary Hospital Outcomes 52

Hypertension Journal

JANUARY 2, 2024

Using Cox proportional hazards regression, we tested interactions between history of cancer and intensive blood pressure control on major cardiovascular outcomes.RESULTS:The study included a total of 9336 patients, with a mean age of 67.9±9.4 years, among whom 2066 (22.2%) were cancer survivors. Hypertension, Ahead of Print.

Blood Pressure 40

Blood Pressure Cancer Outcomes Myocardial Infarction 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Atrial fibrillation (AF) and cancer are both independently associated with worse outcomes in patients with acute ischemic stroke. Few studies have evaluated the impact of AF on outcomes of cancer-related stroke. The primary outcome was in-hospital mortality. The primary exposure was a diagnosis of AF.

Cancer 40

Cancer Atrial Fibrillation Stroke Strokes 40

DAIC

JANUARY 29, 2024

The researchers found that Medicare patients undergoing esophagectomy for cancer exhibit identifiable predictors for long-term survival and readmission. These findings suggest opportunities to enhance clinical practice and improve outcomes for Medicare patients undergoing esophagectomy for cancer.

Research 111

Research TAVR Aortic valve Atrial Fibrillation 111

Heart BMJ

JULY 25, 2024

Background Data on the management of patients with cancer presenting with sudden cardiac arrest (SCA) are scarce. We aimed to assess the characteristics and outcomes of SCA according to cancer history. Results Out of 4069 patients who had SCA admitted alive in hospital, 207 (5.1%) had current or past medical history of cancer.

Cardiac Arrest 52

Cardiac Arrest Cancer Hospital Embolism 52

DAIC

APRIL 9, 2024

Anthracyclines are a well-established class of cancer drugs that are used to treat several types of cancer. While they are effective at eradicating cancer, they are known to carry a risk of causing damage to the heart muscle. The PROACT study will continue to track outcomes in the study participants for at least 12 months.

ACE Inhibitor 105

ACE Inhibitor Cancer Biomarkers Heart Failure 105

DAIC

APRIL 30, 2024

Tricuspid Valve Repair Existing literature on national surgical outcomes of isolated tricuspid valve repair or replacement is based on data from over a decade ago and may not reflect current practice results. Outcomes were worse with increasing surgical urgency, older age, dialysis dependence, and multiple reoperations.

TAVR 111

TAVR Aortic valve Tricuspid Coronary Artery Bypass Graft 111

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

The precise conditions by which cytokines drive cancer is relevant to improving immune checkpoint inhibition (ICI) responses while decreasing toxicity. The authors evaluated T cell populations, cytokine signatures, immune related adverse events (irAEs), and survival outcomes. In this issue of the JCI, Kao et al.

Cancer 95

Cancer Outcomes 95

Open Heart

APRIL 13, 2023

Objective Patients with cancer are at increased bleeding risk, and anticoagulants increase this risk even more. Yet, validated bleeding risk models for prediction of bleeding risk in patients with cancer are lacking. The aim of this study is to predict bleeding risk in anticoagulated patients with cancer.

Cancer 52

Cancer Outcomes 52

Medical Xpress - Cardiology

JULY 11, 2024

New research from the University of Alberta offers the hope of better long-term outcomes for survivors of childhood cancer—and the path to those better outcomes is exercise.

Cancer 40

Cancer Research Exercise Outcomes 40

Circulation

NOVEMBER 11, 2024

Background:The consequences of cancer and anti-cancer treatments are often described as representing an “accelerated aging” phenotype. Participants missing vital data and those diagnosed with multiple cancers, childhood cancers, cancer within the previous 5 years, or skin cancer were excluded.

Cancer 40

Cancer Circulation Outcomes 40

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundPatients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. 30.78];P<0.05).ConclusionsElevated

Cancer 40

Cancer Stroke Strokes Outcomes 40

Society of Thoracic Surgeons - Surgeon

NOVEMBER 3, 2023

While both trials showed similar results, there are important differences in design, demographics, and patients’ outcomes. The presenters will debate the nuances of the trials and their potential applications in clinical practice.

Cancer 52

Cancer Webinar Biomarkers Hospital 52

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. Although generally well tolerated, the administration of ICIs can result in unique side effects known as immune-related adverse events (irAEs).

Pulmonary 81

Pulmonary Cancer Outcomes 81

Journal of Clinical Investigation - Cardiology

JULY 15, 2024

These circadian mechanisms represent potential pathophysiological pathways linking circadian disruption to adverse metabolic health outcomes, including obesity, metabolic syndrome, and type 2 diabetes.

Diabetes 111

Diabetes Obesity Cancer Risk Factors 111

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and the recruitment and behavior of stromal cells. explored the potent anticancer effect of the combination of a glutaminase inhibitor (CB-839) and 5-FU against PIK3CA-mutant colorectal cancer tumors. In this issue of the JCI, Li et al.

Cancer 40

Cancer Outcomes 40

Circulation

NOVEMBER 11, 2024

Limited data indicate an elevated risk of atrial fibrillation (AF) after neoadjuvant chemoradiation in esophageal cancer however the role of AF as an independent predictor of outcomes post-esophagectomy remains under-studied. Outcomes over a 5-year period were mortality, ischemic stroke, and use of anticoagulation.

Atrial Fibrillation 40

Atrial Fibrillation Cancer Outcomes BMI 40

Circulation

NOVEMBER 11, 2024

Background:Cardiovascular disease is an important cause for mortality in cancer patients and cancer is a primary cause of non- cardiac mortality in patients with heart failure. Patients with a principal discharge diagnosis of heart failure were stratified into two groups based on presence of cancer. vs 3.1%; OR: 1.6;

Heart Failure 40

Heart Failure Cancer Hospital Outcomes 40

HeartRhythm

APRIL 30, 2024

Atrial arrhythmias (AA) are common in patients with pulmonary disease and various cancers. However, the association between AA and non-small cell lung cancer (NSCLC), and the impact of AA on overall clinical outcome in patients with NSCLC are not well-known.

Cancer 40

Cancer Arrhythmia Pulmonary Outcomes 40

Circulation

NOVEMBER 11, 2024

Background:Metabolic syndrome and obesity are known to increase the incidence of lung cancer. We investigated the association between metabolic health and overweight/obesity phenotypes and clinical outcomes in patients with resectable non-small cell lung cancer (NSCLC).Methods:This 0.96, p = 0.022).Conclusions:After

Obesity 40

Obesity Cancer Outcomes Circulation 40

HeartRhythm

APRIL 30, 2024

Furthermore the outcomes among patients with known cancer is not well documented. Transvenous lead extraction (TLE) is a revered procedure among Cardiologist.

Cancer 40

Cancer Document Outcomes 40

Journal of Cardiovascular Pharmacology

JUNE 24, 2024

Their impact on the prognostic outcomes among cancer patients has been subject to scrutiny and debate. The aim of this study is to evaluate the effect of RASi on survival in cancer patients. Their impact on the prognostic outcomes among cancer patients has been subject to scrutiny and debate.

Cancer 40

Cancer Hypertension Outcomes Article 40

ECG Cases

JULY 30, 2024

A cultural shift emphasizing the importance of compassion in patient care needs to occur to improve outcomes of our patients and our job satisfaction; as such, compassion should be part of our training and CME. The post Compassionate Care to Improve Patient Outcomes and Your Career from EMU 2024 appeared first on Emergency Medicine Cases.

CME 52

CME Outcomes Cancer Patient Care 52

Circulation

NOVEMBER 11, 2024

Adverse CVD outcomes was defined as a composite of incident heart failure, incident atrial fibrillation / flutter, incident myocardial infarction or all-cause mortality. Adverse CVD outcomes was defined as a composite of incident heart failure, incident atrial fibrillation / flutter, incident myocardial infarction or all-cause mortality.

Cancer 40

Cancer Cardiovascular Disease Myocardial Infarction Stroke 40

Heart BMJ

NOVEMBER 27, 2023

The number of patients at the intersection of cancer and cardiovascular disease (CVD) is increasing, reflecting ageing global populations, rising burden of shared cardiometabolic risk factors, and improved cancer survival. Many cancer treatments carry a risk of cardiotoxicity.

Cardio Oncology 40

Cardio Oncology Cancer Cardiovascular Disease Risk Factors 40

Open Heart

JULY 15, 2022

However, data about the predictive value of CPET for cardiovascular outcome after gastric or oesophageal cancer surgery are inconclusive. Methods This is a prospective single-centre interventional cohort study including 200 consecutive patients who underwent elective surgery for oesophageal and/or gastric cancer. An AT <9.5

Cancer 52

Cancer Exercise Myocardial Infarction Atrial Fibrillation 52

HCPLive

MAY 17, 2024

This analysis may help bring to light more specific skin cancer-related data on the underserved population of non-Hispanic Black, or NHB, patients.

Cancer 52

Cancer Outcomes 52

Medical Xpress - Cardiology

DECEMBER 3, 2024

Early disease detection is beneficial for securing the best possible outcomes for patients. But finding noninvasive, effective ways to predict disease risk is a tremendous challenge.

Cancer 45

Cancer Outcomes 45

Journal of Clinical Investigation - Cardiology

DECEMBER 16, 2024

BRAFV600E-mutant metastatic colorectal cancer (mCRC) is associated with poor prognosis.

Cancer 40

Cancer Outcomes 40

Open Heart

DECEMBER 8, 2022

Background Cancer treatment with vascular endothelial growth factor signalling pathway (VSP) inhibitors frequently causes hypertension. Objectives The study aims to clarify whether RASIs exhibit clinical benefits for patients with cancer with hypertension. to 1.06, p=0.386).

Cancer 40

Cancer Hypertension Outcomes 40