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Long-term Survivors of Childhood Cancer at Higher Risk of Death Following Heart Issues; Threshold for Treating Risk Factors Should be Lower

DAIC

The findings – published this week in the Journal of the American College of Cardiology — could fuel advocacy for a paradigm shift in clinical heart health guidelines to address cardiovascular risk factors at an earlier age in childhood cancer survivors. “We Wendy Bottinor, MD.

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Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis

Heart BMJ

Background Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple ‘hits’ over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. compared with 1.7%

Cancer 98
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Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research

DAIC

Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension (PAH).

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The intersection of heart failure and cancer in women: a review

Frontiers in Cardiovascular Medicine

Cancer and cardiovascular disease represent the two leading causes of morbidity and mortality worldwide. However, this comes at a cost with more women developing diabetes, hypertension and coronary artery disease as they age. Women continue to enjoy a greater life expectancy than men.

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Study suggests hypoxia overexpression causes pericytes to contribute to pulmonary hypertension

Medical Xpress - Cardiology

Pericytes, the multifunctional cells that work within the walls of capillaries, have been a subject of focus in the study of vascular development, cerebral blood flow, cancer, and neurodevelopment diseases.

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Effect of Intensive Blood Pressure Control on Cardiovascular Outcomes in Cancer Survivors

Hypertension Journal

Hypertension, Ahead of Print. Using Cox proportional hazards regression, we tested interactions between history of cancer and intensive blood pressure control on major cardiovascular outcomes.RESULTS:The study included a total of 9336 patients, with a mean age of 67.9±9.4 years, among whom 2066 (22.2%) were cancer survivors.

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Personal Genetic-Hypertension Odyssey From Phenotypes to Genotypes and Targets

Hypertension Journal

Hypertension, Ahead of Print. Hypertension requires increased systemic vascular resistance. Thus far, Mendelian hypertension–related genes are related to salt retention, an indirect regulatory effect. Hypertension and the bony phenotype invariably occur together.