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Long-term Survivors of Childhood Cancer at Higher Risk of Death Following Heart Issues; Threshold for Treating Risk Factors Should be Lower

DAIC

The findings – published this week in the Journal of the American College of Cardiology — could fuel advocacy for a paradigm shift in clinical heart health guidelines to address cardiovascular risk factors at an earlier age in childhood cancer survivors. “We Wendy Bottinor, MD.

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Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research

DAIC

Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension (PAH).

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Effect of Intensive Blood Pressure Control on Cardiovascular Outcomes in Cancer Survivors

Hypertension Journal

Hypertension, Ahead of Print. Using Cox proportional hazards regression, we tested interactions between history of cancer and intensive blood pressure control on major cardiovascular outcomes.RESULTS:The study included a total of 9336 patients, with a mean age of 67.9±9.4 years, among whom 2066 (22.2%) were cancer survivors.

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The potential impact of renin-angiotensin system inhibitors on cancer survival and recurrence: A systemic review and meta-analysis

Journal of Cardiovascular Pharmacology

Renin-angiotensin-system inhibitors (RASi), specifically angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs), are widely used anti-hypertensives. Their impact on the prognostic outcomes among cancer patients has been subject to scrutiny and debate. 0.93; P=0.01) in cancer patients.

Cancer 40
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Study suggests hypoxia overexpression causes pericytes to contribute to pulmonary hypertension

Medical Xpress - Cardiology

Pericytes, the multifunctional cells that work within the walls of capillaries, have been a subject of focus in the study of vascular development, cerebral blood flow, cancer, and neurodevelopment diseases.

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Endothelin System in Hypertension and Chronic Kidney Disease

Hypertension Journal

Hypertension, Ahead of Print. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc.

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Heart Disease Mortality in Cancer Survivors: A Population?Based Study in Japan

Journal of the American Heart Association

BackgroundData on the risk of cardiovascular‐related mortality in patients with cancer are limited.Methods and ResultsThis retrospective cohort study used data from the Osaka Cancer Registry and vital statistics in Japan between 1985 and 2013. The risk of fatal heart disease increased over time after cancer diagnosis.

Cancer 40