Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death across different metastatic breast cancer subtypes.

Cancer 133

Cancer Outcomes 133

Med Page Today

JULY 6, 2024

(MedPage Today) -- Long-term cancer survivors tended to live longer if they consumed a Mediterranean diet, analysis of an Italian cohort study found. With a follow-up of almost 13 years, survivors with high adherence to the diet had a 32% lower.

Diet 122

Diet Cancer 122

HCPLive

FEBRUARY 29, 2024

Cancer patients with behavioral health disorders, such as substance abuse, eating disorders, and sleep disorders have a 7.76% increase in health care costs, a new study found.

Cancer 123

Cancer 123

DAIC

JUNE 19, 2024

Getty Images milla1cf Wed, 06/19/2024 - 20:54 June 19, 2024 — Modern therapies have extended the lives of many cancer patients; however, survivors often live with chronic health conditions, including cardiovascular disease. They found that exposure to PM2.5,

Cardio Oncology 111

Cardio Oncology Cancer Health Disparities Cardiovascular Disease 111

Medical Xpress - Cardiology

JANUARY 11, 2024

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors.

Biomarkers 116

Biomarkers Cancer Cardiac Function Cardiomyopathy 116

HCPLive

OCTOBER 4, 2024

The approval is based on findings from BLUE-C, where Cologuard Plus demonstrated sensitivities of 95% for colorectal cancer and 43% for advanced precancerous lesions at 94% specificity.

Cancer 115

Cancer 115

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients.

Cancer 119

Cancer 119

Nature Reviews - Cardiology

APRIL 9, 2024

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01017-x Patients with cardiovascular disease (CVD) have an increased risk of cancer, and patients with cancer have an increased risk of CVD.

Risk Factors 105

Risk Factors Cardiovascular Disease Cancer 105

Science Daily - Heart Disease

JUNE 3, 2024

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that inhibiting CDK7 could help enhance the medication's cancer-killing capability.

Cancer 104

Cancer Research 104

Med Page Today

OCTOBER 8, 2024

(MedPage Today) -- BOSTON -- Patients with metastatic lung cancer who were treated with immune checkpoint inhibitors (ICIs) had higher odds of developing a pulmonary embolism, according to a retrospective cohort study. Among propensity-matched.

Embolism 111

Embolism Cancer Pulmonary 111

Med Page Today

JULY 5, 2024

(MedPage Today) -- GLP-1 receptor agonists lowered the risk of several obesity-associated cancers, a retrospective analysis of electronic health records suggested. Compared with insulin, GLP-1s were associated with a lower risk for developing.

Obesity 116

Obesity Cancer Diabetes 116

Med Page Today

SEPTEMBER 26, 2024

(MedPage Today) -- Recent skin cancer risk stratification guidelines did not improve rates of timely dermatologic follow-up visits among solid organ transplant recipients, according to an analysis of claims data. The rate of post-transplant dermatology.

Transplant 111

Transplant Cancer 111

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Salivary gland dysfunction is a common side effect of cancer treatments. Consequently, changes in salivary function can profoundly impair quality of life for cancer patients. Current and emerging approaches to treat cancer therapy–induced dry mouth are presented using radiation-induced salivary dysfunction as a model.

Cancer 96

Cancer Quality of Life Anatomy Pharmacology 96

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underlying cues may provide novel strategies for managing metastatic disease.

Cancer 94

Cancer Education 94

Medical Xpress - Cardiology

AUGUST 20, 2024

Researchers from Brigham and Women's Hospital have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

Cancer 111

Cancer Arrhythmia Hospital Research 111

Medical Xpress - Cardiology

SEPTEMBER 16, 2024

New evidence shows that extended estrogen suppression treatment using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.

Cancer 117

Cancer Heart Disease Atherosclerosis 117

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified.

Cancer 116

Cancer Pharmacology Ablation 116

Med Page Today

DECEMBER 12, 2024

(MedPage Today) -- The non-small cell lung cancer (NSCLC) drug osimertinib (Tagrisso) was associated with an increased risk of therapy-related cardiovascular (CV) events compared with older EGFR inhibitors, a retrospective cohort study from Taiwan.

Cancer 98

Cancer 98

Medical Xpress - Cardiology

JULY 2, 2024

The Mediterranean diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation—Department of Epidemiology and Prevention of the I.R.C.C.S.

Diet 115

Diet Cancer Cardiovascular Disease Research 115

Med Page Today

JUNE 6, 2024

(MedPage Today) -- The addition of androgen receptor signaling inhibitors (ARSIs) alongside standard androgen deprivation therapy (ADT) in advanced prostate cancer was associated with a significantly increased risk of adverse heart events, a systematic.

Cancer 111

Cancer 111

Open Heart

FEBRUARY 27, 2024

Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. vs 74.7%, p=0.50).

Aortic valve 98

Aortic valve Cancer Aortic TAVR 98

HCPLive

JUNE 10, 2024

Study from RAD 2024 finds 36% higher risk of nonmelanoma skin cancer in patients with atopic dermatitis relative to matched controls.

Cancer 111

Cancer 111

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Several poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved by FDA to treat cancer with BRCA mutations. A high expression level of GSDMC predicted better response to PARPi treatment in patients with triple-negative breast cancer (TNBC). BRCA mutations are considered to fuel a PARPi killing effect by inducing apoptosis.

Cancer 105

Cancer 105

DAIC

JANUARY 29, 2024

occurrence of postoperative PE in patients undergoing a first-time pulmonary resection for lung cancer. The researchers found no difference in PE risk based on how well the lungs functioned before surgery, cancer cell type (histology), or whether or not the patients received chemotherapy before surgery.

Cancer 116

Cancer Pulmonary Research Blood Clot 116

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Whether NETs can kill cancer cells is unexplored. Here, we report that a combination of glutaminase inhibitor CB-839 and 5-FU inhibited the growth of PIK3CA-mutant colorectal cancers (CRCs) in xenograft, syngeneic, and genetically engineered mouse models in part through NETs.

Cancer 111

Cancer 111

HCPLive

NOVEMBER 12, 2024

These results point to the value of awareness among physicians and patients of the risk of psoriasis linked to immunotherapy during cancer care.

Cancer 105

Cancer 105

Med Page Today

DECEMBER 8, 2023

(MedPage Today) -- Pharmacovigilance is needed to identify, monitor, and prevent cardiovascular adverse events (CV-AEs) associated with new agents for breast cancer and to reduce the risk of cardiotoxicity for the growing number of survivors, according.

Cancer 119

Cancer 119

Science Daily - Heart Disease

DECEMBER 2, 2024

A cancer therapy that prompts the body's immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke. A possible explanation for this side effect is that the treatment interferes with immune regulation in the heart's largest blood vessels, a new study suggests.

Cancer 97

Cancer Heart attacks Heart Attack Heart Disease 97

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Microscopic hemorrhage is a common aspect of cancers, yet its potential role as an independent factor influencing both cancer progression and therapeutic response is largely ignored. These TAMs stabilized epithelial-mesenchymal transition, enhancing cancer invasiveness and metastatic potential.

Cancer 98

Cancer Hemorrhage 98

Medical Xpress - Cardiology

FEBRUARY 2, 2024

To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional "heart-on-a-chip" to evaluate drug safety. Chemotherapy can be toxic to heart cells.

Cancer 114

Cancer 114

DAIC

FEBRUARY 28, 2024

The findings – published this week in the Journal of the American College of Cardiology — could fuel advocacy for a paradigm shift in clinical heart health guidelines to address cardiovascular risk factors at an earlier age in childhood cancer survivors. “We Wendy Bottinor, MD.

Risk Factors 105

Risk Factors Cancer Cardio Oncology Blood Pressure 105

Heart BMJ

SEPTEMBER 16, 2024

Background Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple ‘hits’ over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. compared with 1.7%

Cancer 98

Cancer Heart Failure Risk Factors Hypertension 98

HCPLive

DECEMBER 12, 2023

In a new study, a subgroup analysis demonstrated a reduced risk of colorectal cancer among patients <65 years old with gout.

Cancer 105

Cancer 105

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Following a period of slow progress, the completion of genome sequencing and the paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led to a new perspective on the biology and therapeutic solutions for this deadly cancer.

Cancer 92

Cancer Research 92

Med Page Today

NOVEMBER 19, 2024

(MedPage Today) -- Adding an anthracycline to adjuvant chemotherapy for TOP2A-normal early breast cancer significantly improved disease-free survival (DFS) but not overall survival (OS) at 10 years, and doubled the risk of heart failure, a randomized.

Cancer 97

Cancer Heart Failure 97

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Here, we show in a mouse tumor model representative of human lymphocyte–depleted cancer that RT enhanced spontaneous priming of thymus-derived (FOXP3+Helios+) Tregs by the tumor. Radiotherapy (RT) is considered immunogenic, but clinical data demonstrating RT-induced T cell priming are scarce.

Cancer 115

Cancer 115

HCPLive

SEPTEMBER 17, 2024

Mathew emphasizes the importance of routine liver cancer screening in patients with advanced liver disease and the need to overcome insurance barriers for HCC panel testing.

Cancer 94

Cancer 94