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NAFLD Presents Similar Risk for Adverse Outcomes Regardless of BMI

HCPLive

Patients with lean NAFLD had fewer metabolic comorbidities but maintained similar risk of NASH, cirrhosis, nonliver cancer, and mortality compared to their overweight and obese counterparts.

BMI 105
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BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Cardiovascular Diabetology

BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been la.

BMI 59
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Why Mechanical AVR Valves Still Matter

CardiacWire

They also often had lower BMI (31.0 The studys design also wasnt powered to make any certain conclusions due to its reliance on registry data, meaning a randomized head-to-head trial would be needed to confirm these outcomes. Patients receiving bioprosthetic valves tended to be older (65.2 vs 71.8%) or prior PCI (6.7

BMI 80
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Obesity and acute type A aortic dissection: unraveling surgical outcomes through the lens of the upper hemisternotomy approach

Frontiers in Cardiovascular Medicine

Obesity, a pervasive health concern, has been identified as a significant risk factor for ATAAD, introducing unique surgical challenges that can influence postoperative outcomes. Based on BMI (WS/T 428-2013), patients were categorized into normal weight, overweight, and obese. Further ROC curve analysis identifies a BMI cutoff of 25.5

Obesity 64
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BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease

Cardiovascular Diabetology

Understanding the relationship between serum ferritin levels and cardiovascular outcomes in type 2 diabetes is crucial for improving risk stratification and guiding therapeutic interventions aimed at preventin.

BMI 59
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Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study

Cardiovascular Diabetology

Associations between metabolic status and metabolic changes with the risk of cardiovascular outcomes have been reported. However, the role of genetic susceptibility underlying these associations remains unexpl.

BMI 52
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Mineralys Therapeutics Announces Phase 2 Clinical Trial of Lorundrostat

DAIC

This program aligns with our strategy to develop lorundrostat in conditions driven by dysregulated aldosterone, with poor cardiovascular outcomes and few treatment options, stated Jon Congleton, Chief Executive Officer of Mineralys Therapeutics. The primary outcome measure is absolute change in the frequency of apnea-hypopnea episodes.