BMI, Heart Failure and Hypertension - Cardiovascular Update

Hypertensive pregnancy disorder, an under‐recognized women specific risk factor for heart failure?

European Journal of Heart Failure

NOVEMBER 19, 2024

Hypertensive disorders of pregnancy as a risk factor for heart failure. BMI, body mass index; CV, cardiovascular; CVD, cardiovascular disease; HELLP, haemolysis, elevated liver enzymes, low platelet count.

Risk Factors

Risk Factors Heart Failure Hypertension Preserved Ejection Fraction

Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP?HF II trial

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). of patients had BMI ≥30 kg/m 2. Strain measurements in all four chambers were maintained as BMI increased. Overall, 60.9%

Preserved Ejection Fraction

Preserved Ejection Fraction Obesity Heart Failure BMI

Abstract WP294: Racial Disparities among the risk of Stroke and other clinical outcomes post Infective Endocarditis: A Propensity Matched Analysis

Stroke Journal

JANUARY 30, 2025

Propensity score-matched analysis (PSM) (1:1) was performed on age, gender, BMI, hypertension, diabetes mellitus, chronic kidney disease, hemoglobin level, LDL level, left ventricular ejection fraction and various drugs including beta blockers, ACEi and ARBi. The mean age of patients was comparable between both groups (59.8

Cardiogenic Shock

Cardiogenic Shock Strokes Stroke Outcomes

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Abstract 52: Glucagon-like peptide-1 receptor agonists use and outcomes in Cardiac Amyloidosis patients: A Propensity Matched Analysis

Stroke Journal

JANUARY 30, 2025

Propensity score-matched analysis (PSM) (1:1) was performed with matching for age, gender, race, BMI, hypertension, diabetes mellitus, chronic kidney disease, hemoglobin level, low-density lipid (LDL) level, left ventricular ejection fraction, and various drugs including ACEi, ARBi, ARNI, beta-blockers, and diuretics.

Outcomes

Outcomes Atrial Fibrillation Heart Failure Tachycardia

Finerenone, chronic obstructive pulmonary disease, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

European Journal of Heart Failure

APRIL 13, 2025

The beneficial effects of finerenone in patients with heart failure (HF) and mildly reduced or preserved ejection fraction were consistent, regardless of a history of chronic obstructive pulmonary disease (COPD) status. BMI, body mass index; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-B-type natriuretic peptide.

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Pulmonary Peripheral Arterial Disease

Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

JULY 25, 2023

There are significant data that show that if you have obesity, you have a high risk of developing coronary heart disease, heart failure, type 2 diabetes (T2D) or risk factors such as hypertension and dyslipidemia. [1] to 25 kg/m2) and underweight (BMI less than 18.5 Is the obesity paradox a real phenomenon?

Obesity

Obesity BMI Heart Failure Cardiovascular Disease

Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

ObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n=47) and a non-diabetic group (non-T2DM group, n=61).

Exercise

Exercise Heart Failure Diabetes BMI

Abstract 4146852: Impact of Left Ventricular Diastolic Function in Pulmonary Arterial Hypertension Outcomes

Circulation

NOVEMBER 11, 2024

Introduction:The demographics of patients with pulmonary arterial hypertension (PAH) is shifting towards older age, increased comorbidity burden, and an increase in the risk of left ventricular (LV) diastolic dysfunction. Results:Overall, 140 participants were identified (age: 56±16 years; BMI: 30.04±8.04 2022 were included.

Pulmonary

Pulmonary Hypertension Preserved Ejection Fraction Outcomes

Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

Open Heart

AUGUST 5, 2022

Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. The study population comprised 40 482 participants: 703 underweight (BMI <18.5 kg/m 2 ), 13 095 normal (BMI=18.5–24.9

Atrial Fibrillation

Atrial Fibrillation BMI Outcomes Obesity

Semaglutide Leads to Greater Weight Loss in Women than Men with HF, Improves HF Symptoms in Both Sexes

DAIC

JUNE 26, 2024

Getty Images milla1cf Wed, 06/26/2024 - 18:59 June 26, 2024 — Semaglutide , a medication initially developed for type 2 diabetes and obesity, significantly improves symptoms in men and women with a common type of heart failure that has had few therapeutic options. It also lowered their systolic blood pressure and waist circumference.

Preserved Ejection Fraction

Preserved Ejection Fraction Obesity BMI Heart Failure

Association between body mass index and clinical outcomes in patients with acute myocardial infarction and reduced systolic function: Analysis of PARADISE‐MI trial data

European Journal of Heart Failure

DECEMBER 18, 2024

Association between body mass index (BMI) and clinical outcomes in PARADISE-MI. ( A ) Histogram for BMI (kg/m 2 ), ( B ) adverse events for BMI subgroups, and spline model curves for ( C ) the primary composite outcome and ( D ) cardiovascular (CV) death by BMI subgroups. 100 patient-years for BMI 40kg/m 2 ).

Myocardial Infarction

Myocardial Infarction BMI Outcomes Heart Failure

Machine learning approach to identify phenotypes in patients with ischaemic heart failure with reduced ejection fraction

European Journal of Heart Failure

DECEMBER 10, 2024

Aims Patients experiencing ischaemic heart failure with reduced ejection fraction (HFrEF) represent a diverse group. Association between clusters and the composite of (i) heart failure hospitalization or all-cause death, (ii) cardiovascular (CV) hospitalization or all-cause death, and (iii) major adverse CV events was assessed.

Heart Failure

Heart Failure Peripheral Arterial Disease Blood Pressure Atrial Fibrillation

Abstract WP388: Plasma Eicosanoids Are Associated with Incident Stroke Over Decades in Participants in the Atherosclerosis Risk in Communities (ARIC) Study

Stroke Journal

JANUARY 30, 2025

Results:Among the 9,444 participants included, the mean age was 57 (5.7 SD), and 43.2% were men.

Atherosclerosis

Atherosclerosis Strokes Stroke Atrial Fibrillation

Physiology Friday #196: Resistance Training and Heart Health

Physiologically Speaking

DECEMBER 15, 2023

Of course, these benefits can also extend to individuals with a BMI in the normal range. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).

Physiology

Physiology Exercise Blood Pressure Risk Factors

Physiology Friday #196: Resistance Training and Heart Health

Physiologically Speaking

DECEMBER 15, 2023

Of course, these benefits can also extend to individuals with a BMI in the normal range. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).

Physiology

Physiology Exercise Blood Pressure Risk Factors

Abstract 4141539: Impact of Left Ventricular End-Diastolic Diameter on the Prognosis in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Undergoing PCI

Circulation

NOVEMBER 11, 2024

Studies have shown that an increased left ventricular end-diastolic diameter (LVEDD) is associated with worse outcomes in various cardiovascular conditions, including heart failure, and coronary artery disease (CAD). The restrictive cubic spline in Figure 2 showed that LVEDD greater than 60 mm increased the risk of MACEs.

Atrial Fibrillation

Atrial Fibrillation Coronary Artery Bypass Graft Coronary Artery Disease Myocardial Infarction

Association between asthma and cardiovascular disease: evidence from the national health and nutrition examination survey 1999–2018

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2024

CVD included stroke, congestive heart failure, coronary heart disease, and angina. Compared with participants without asthma, the prevalence of stroke in those with asthma was increased by 1.607 times; the prevalence of congestive heart failure was increased by 1.911 times.

Cardiovascular Disease

Cardiovascular Disease Heart Failure Angina BMI

Hypertensive pregnancy disorder, an under‐recognized women specific risk factor for heart failure?

Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP?HF II trial

Abstract WP294: Racial Disparities among the risk of Stroke and other clinical outcomes post Infective Endocarditis: A Propensity Matched Analysis

Webinars

Abstract 52: Glucagon-like peptide-1 receptor agonists use and outcomes in Cardiac Amyloidosis patients: A Propensity Matched Analysis

Finerenone, chronic obstructive pulmonary disease, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise

Abstract 4146852: Impact of Left Ventricular Diastolic Function in Pulmonary Arterial Hypertension Outcomes

Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

Semaglutide Leads to Greater Weight Loss in Women than Men with HF, Improves HF Symptoms in Both Sexes

Association between body mass index and clinical outcomes in patients with acute myocardial infarction and reduced systolic function: Analysis of PARADISE‐MI trial data

Machine learning approach to identify phenotypes in patients with ischaemic heart failure with reduced ejection fraction

Abstract WP388: Plasma Eicosanoids Are Associated with Incident Stroke Over Decades in Participants in the Atherosclerosis Risk in Communities (ARIC) Study

Physiology Friday #196: Resistance Training and Heart Health

Physiology Friday #196: Resistance Training and Heart Health

Abstract 4141539: Impact of Left Ventricular End-Diastolic Diameter on the Prognosis in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Undergoing PCI

Association between asthma and cardiovascular disease: evidence from the national health and nutrition examination survey 1999–2018

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