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Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients with Heart Failure with Preserved Ejection Fraction and Obesity: A Prespecified Analysis of the STEP-HFpEF Trial

Circulation

Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. In the STEP-HFpEF trial, once-weekly semaglutide 2.4 mg or placebo for 52 weeks.

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Abstract 4146852: Impact of Left Ventricular Diastolic Function in Pulmonary Arterial Hypertension Outcomes

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4146852-A4146852, November 12, 2024. The H2FPEF score and probability were developed to assist in heart failure with preserved ejection fraction (HFpEF) diagnosis. Results:Overall, 140 participants were identified (age: 56±16 years; BMI: 30.04±8.04 2022 were included.

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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2. These individuals tend to have a better prognosis when compared to both individuals with normal weight (BMI of 18.5 to 25 kg/m2) and underweight (BMI less than 18.5

Obesity 52
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Abstract 4118122: Effect of Beta Blockers on Exercise Capacity, Diastolic Function, and Quality of Life in Patients with Heart Failure with Preserved Ejection Fraction

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4118122-A4118122, November 12, 2024. Patients studied were older (68 years old), white (90%), obese (average BMI 34 kg/m2) individuals with an average LVEF of 61%. Baseline demographics are shown in Table 1.