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NAFLD Presents Similar Risk for Adverse Outcomes Regardless of BMI

HCPLive

Patients with lean NAFLD had fewer metabolic comorbidities but maintained similar risk of NASH, cirrhosis, nonliver cancer, and mortality compared to their overweight and obese counterparts.

BMI 105
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Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer

Journal of Clinical Investigation - Cardiology

Obesity is a known driver of endometrial cancer. In this issue of the JCI, Gómez-Banoy and colleagues investigated a cohort of patients with advanced endometrial cancer treated with immune checkpoint inhibitors targeting the interaction between programmed cell death receptor-1 (PD-1) and its ligand (PD-L1).

Cancer 63
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Abstract 4142376: Impact of Atrial Fibrillation on Outcomes in Patients with Esophageal Cancer Receiving Neoadjuvant Chemoradiation

Circulation

Limited data indicate an elevated risk of atrial fibrillation (AF) after neoadjuvant chemoradiation in esophageal cancer however the role of AF as an independent predictor of outcomes post-esophagectomy remains under-studied. Outcomes over a 5-year period were mortality, ischemic stroke, and use of anticoagulation.

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Decoding Longevity. How To Not Die. Young

Dr. Paddy Barrett

Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. Let’s start with Cancer. Compared to those who had ‘Low’ lifestyle scores, those with ‘Ideal’ scores were 27% less likely to be diagnosed with cancer in the next ten years. The leading causes of death are clear.

Cancer 80
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Living Past 100: Insights from Centenarians on a Long, Healthy Life

Dr. Paddy Barrett

It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. J Gerontol A Biol Sci Med Sci.

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Abstract 4148106: Hemophilia and Cardiovascular disease in the United States: Prevalence, Risk factors, and outcomes.

Circulation

The primary outcome was to estimate the prevalence of cardiovascular risk factors in patients with hemophilia compared to the general population. Further research is to identify potential ex-specific risk factors that predispose to worse cardiovascular outcomes among patients with hemophilia.

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Physiology Friday #202: Should You be Taking a Multivitamin for Cognitive Health? A New Study Suggests Yes.

Physiologically Speaking

However, there’s not great evidence that multivitamins benefit specific health outcomes. This hypothesis was studied in a randomized controlled trial known as the COcoa Supplement and Multivitamin Outcomes Study or COSMOS. Nutritional insurance? A health- and longevity-boosting powerhouse? Perhaps not.