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Novel pharmacological approaches to lowering blood pressure and managing hypertension

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 07 February 2025; doi:10.1038/s41569-025-01131-4 Hypertension is the leading cause of death globally but has low rates of diagnosis and treatment.

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One Injection of Novel Drug Cuts Systolic Blood Pressure by Up to 12 mmHg

DAIC

Akshay Desai, MD “Compared to placebo, a single injection of zilebesiran resulted in clinically meaningful reductions in blood pressure at three months when added to commonly used antihypertensive treatments,” said Akshay Desai, MD, MPH , a cardiologist at Brigham and Women’s Hospital in Boston and a study coauthor. “In

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Renal Denervation for the Treatment of Hypertension: A Scientific Statement From the American Heart Association

Hypertension Journal

Hypertension, Ahead of Print. Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening.

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Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association

Hypertension Journal

Hypertension, Ahead of Print. Although orthostatic hypotension (OH) has long been recognized as a manifestation of autonomic dysfunction, a growing body of literature has identified OH as a common comorbidity of hypertension. These strategies include countermaneuvers and short-acting vasoactive agents (midodrine, droxidopa).

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Pyridostigmine in the management of orthostatic hypotension: a systematic review and meta-analysis

Open Heart

Background Current pharmacological approaches for the treatment of orthostatic hypotension (OH) may detrimentally affect supine blood pressure (BP). Pyridostigmine has been proposed as a potential treatment alternative which may improve OH without worsening supine hypertension.

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Blood pressure management in type 2 diabetes: a review of recent evidence

Heart BMJ

The frequent concurrence of elevated blood pressure (BP) and type 2 diabetes markedly elevates the risk of cardiovascular disease and mortality. The review introduces a mediation model, delineating the intricate interplay between hypertension and diabetes and their joint contribution to cardiovascular and renal pathologies.

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Efficacy of acupuncture for hypertension in the elderly: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Background Hypertension has now developed into a major public health problem worldwide. Acupuncture, a core technique in the non-pharmacological treatment of Chinese medicine, plays an important role in the treatment of elevated blood pressure. to −6.06, P  < 0.01) and DBP (MD: −7.04, 95% CI: −10.83