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The primary outcome was functional status measured by the modified Rankin Scale at 90 to 180 days. Earlier SBP control was associated with better functional outcomes (modified Rankin Scale score, 3–6; odds ratio, 0.98 [95% CI, 0.97–0.99]) SD, 13.0], 2120 [36.8%] females) were included in analyses.
Background:The deleterious effects of intensive bloodpressure (BP) lowering in patients who achieved successful reperfusion may result from high BP variability (BPV). TR fully mediated the association between intensive BP management and functional outcomes. Stroke, Volume 56, Issue Suppl_1 , Page A119-A119, February 1, 2025.
Background:Systolic bloodpressure (SBP) fluctuation is linked to increased death or disability in intracerebral hemorrhage (ICH) patients. Stroke, Volume 56, Issue Suppl_1 , Page A85-A85, February 1, 2025. These findings suggest this time window is crucial for future interventions aimed at controlling SBP in ICH patients.
BACKGROUND:Data on systolic bloodpressure (SBP) trajectories in the first 24 hours after endovascular thrombectomy (EVT) in acute ischemic stroke are limited. 2.82]), intracranial hemorrhage (aOR, 1.84 [95% CI, 1.31–2.59]), 2.31]), and worse functional outcomes (adjusted common odds ratio,1.92 [95% CI, 1.47–2.50]).CONCLUSIONS:Patients
Current guidelines for bloodpressure (BP) management in patients with intracerebral hemorrhage (ICH) recommend acute lowering of systolic BP (SBP) to 140 mm Hg with a maintenance goal of 130 - 150 mm Hg. Outcome was considered good if the patients were discharged home or had discharge mRS of 0-2.
Introduction:Prospective studies and secondary analyses from clinical trials have identified increased systolic bloodpressure variability (SBPV) as a risk factor for poor outcomes. The primary outcome was severe disability or death (SDD; modified Rankin Scale ≥4) at 90-days after discharge.
These data from the SHINE trial continue to inform the national stroke community about potential approaches to treating hyperglycemic stroke patients to assure better outcomes,” she said. These brain bleeds, known as symptomatic intracerebral hemorrhages, are considered one of the most dangerous complications of ischemic stroke treatment.
Background and Issues:Timely identification and intervention are critical for positive outcomes in acute intracerebral hemorrhage (ICH) patients. Outcomes were measured using data for when the goals were being met versus not being met.Results:Outcomes were measured from 111 ICH patients from 2022-2023.
BACKGROUNDAlthough postprocedure bloodpressure (BP) correlates with outcome in patients undergoing endovascular thrombectomy (EVT), the optimal target is unknown.METHODSWe performed a pilot randomized‐controlled clinical trial enrolling participants with persistently elevated BP after successful EVT. participants/month).
Background and Objectives:There are limited data evaluating the optimum bloodpressure (BP) goal post mechanical thrombectomy (MT) and its effect on outcomes of patients with large vessel occlusions (LVO). The primary outcome was functional independence (modified Rankin Scale [mRS] 0-2) at 3 months. 1.66, P =0.19).Conclusion:This
Intracerebral hemorrhage is the most serious type of stroke, leading to high rates of severe disability and mortality. Hematoma expansion is an independent predictor of poor functional outcome and is a compelling target for intervention. Stroke, Ahead of Print.
Background:Elevated bloodpressure (BP) is common after Intracerebral Hemorrhage (ICH) and is linked with increased morbidity and mortality, partly due to hematoma expansion. On pooling the results of smaller RCTs (<100 patients) with those from larger trials, none of the above outcomes were significant.
Background:Optimal Bloodpressure management after thrombectomy for acute ischemic stroke and its association with clinical outcomes remains unclear. We performed this study to compare clinical outcomes between intensive systolic bloodpressure (SBP) control (<120-140mmHg) and conventional SBP control (< 180mmHg).Methods:In
Recent landmark trials BEST-MSU and B_PROUD have proven that MSUs facilitate quicker thrombolysis times and improved functional outcomes at 90 days when compared to conventional emergency medical services (EMS) for acute ischemic stroke patients. Goal bloodpressure was defined as systolic bloodpressure <160.
Introduction:Oxidative stress plays an important role in both early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage (SAH). In this study, we evaluated the effect of MnP-05 on short-term outcomes of SAH in mice.Methods:We used 12-week-old male C57BL/6J mice. P<0.05, Fig.
BackgroundDelayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. The lack of standardized experimental setups and outcome assessments, particularly regarding secondary vasospastic/ischemic events, may be partly responsible for the translational failure.
Introduction:Intracerebral hemorrhage (ICH) leads to the highest mortality among stroke patients. ICH expansion causes worse outcomes, especially with anticoagulant-associated ICH. The checklist tracks bloodpressure (BP) management and calling a neurosurgery consult.
Background:Anticoagulation-associated intracerebral hemorrhage (AC-ICH) often results in death. For patients with available door-to-treatment (DTT) times, outcomes were analyzed using logistic regression models adjusted for demographic, history, baseline, and hospital characteristics.
Background:We have previously identified that hemoglobin decrements and new-onset anemia during an intracerebral hemorrhage (ICH) hospitalization is frequent, rapid, and associates with poor outcome. Stroke, Volume 55, Issue Suppl_1 , Page AWP176-AWP176, February 1, 2024. The mean age was 66.5 (SD were female. 0.99, p=0.04).
Background:Mobile stroke units (MSUs) improve outcomes in thrombolytic-eligible ischemic stroke patients. The primary outcome was utility weighted modified Rankin Scale (uw-mRS) at 90 days; secondary outcomes were hematoma expansion, length of inpatient stay, favorable discharge disposition or 90-day mRS, and mortality.
Introduction:Intracerebral hemorrhage (ICH) is associated with poor outcomes in part due to a lack of perceived sense of urgency. HE was defined as per revised criteria (33% relative or 6 mL absolute increase in ICH volume, or new presence or 1mL increase in intraventricular hemorrhage).Results:Among
Introduction:Intracranial hemorrhage (ICH) is the most severe adverse effect of anticoagulation in atrial fibrillation (AF) patients. Stroke, Volume 56, Issue Suppl_1 , Page A49-A49, February 1, 2025. Hypertension, diabetes, hyperlipidemia, and chronic kidney disease are well-known cardiovascular risk factors for ICH.
Background:Long term follow-up data on elevated bloodpressure (BP) or antihypertensive drugs in young adults are scarce. The primary outcome was a composite of the incidence of myocardial infarction and ischemic and hemorrhagic stroke, obtained by tracking the medical use data of the first-ever ICD-10 codes.
Background:Endovascular thrombectomy (EVT) has improved both short-term and long-term outcomes for acute ischemic stroke (AIS) patients caused by large vessel occlusion (LVO). However, the relationships between bloodpressure (BP) after EVT and outcomes had not been determined.
Background:One of the keys to mitigating adverse outcomes of an ischemic or hemorrhagic stroke is timely access to a stroke center. For intracerebral hemorrhage, early intensive bloodpressure lowering within 2 hours of onset improved outcomes.
The primary outcome was functional independence (modified Rankin Scale score of 0–2) at 90 days. Safety outcomes included symptomatic intracranial hemorrhage and 3-month mortality. Compared with alteplase, tirofiban was not associated with increased risk of symptomatic intracranial hemorrhage (6.8% versus 9.2%;P=0.51)
Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH). The mean length of ICU-stay for the HIM group was 32.8
1] This might result in worse outcomes, despite successful recanalization, from hyper‐ or hypoperfusion with a risk for hemorrhagic conversion or larger stroke volume, respectively. Follow up imaging revealed hemorrhagic conversion in the bed of the stroke with intraparenchymal bleeding (PH1) (Figures 1F‐H).This
BackgroundTransport by mobile stroke units (MSUs), which provide access to computed tomography scanning and intravenous bloodpressure medications and thrombolytics, reduces time to treatment and may improve shortterm functional outcomes for patients with acute stroke. had an intracerebral hemorrhage, and 31.1%
In light of postoperative CT head showing SAH in the basilar, perimesencephalic, prepontine cisterns, interhemispheric fissure and right frontal sulci as well as intraventricular hemorrhage in fourth ventricle, her presentation was thought to be secondary to cerebral vasospasm in the setting of postoperative SAH. Daily TCDs were followed.
Because the patient had asystole, was resuscitated without difficulty, and had no neurologic function, suspected a cerebral hemorrhage was suspected as the etiology of the arrest, specifically subarachnoid hemorrhage. She went for a head CT and had a severe subarachnoid hemorrhage (SAH) due to ruptured aneurysm.
Background:Blood pressure (BP) reduction is associated with better neuroimaging and clinical outcomes in patients with spontaneous, non-traumatic intracerebral hemorrhage (ICH). We fitted multivariable logistic regression models to test for association between the intervention and our outcomes of interest.
Introduction:Selected studies link high systolic bloodpressure variability (SBPV) to poor patient outcome after intracerebral hemorrhage (ICH). Hemorrhage characteristics and cerebral small vessel disease burden (CSVD; STRIVE 2.0 Median hemorrhage volume was 12.1 [1.9-36.3] Hispanic, 8.2% Asian, and 2.5%
Introduction:Elevated bloodpressure (BP) is common in acute intracerebral hemorrhage (ICH) and is associated with poor neurological outcomes. Patients underwent 24-hour noninvasive BP monitoring, and clinical outcomes were recorded at 24 hours. years, 263 [62.0%] male).
Optimal cut points for predicting 90-day clinical outcomes (death or major disability [defined as modified Rankin Scale scores 3–6], major disability [defined as modified Rankin Scale scores 3–5], and death alone) were determined using the Youden index. Similar findings were observed when assessing the outcome of major disability.
Disparities in outcomes of patients with ischemic stroke have been associated with insurance coverage. However, there are few studies investigating the impact of insurance status on outcomes in patients with intracerebral hemorrhage (ICH).Methods:We Table 1 illustrates demographics by insurance status. 2.03, p=0.022, Figure 1).
Introduction:Education, a key modifiable social determinant of health, plays a significant role in shaping outcomes related to ischemic stroke. The predicted probability of good outcome by education level was significantly different (Figure 1). See Table 1 for demographics by education group. 3.85, p=0.002).Conclusion:Our
Background:Ischemic lesions on diffusion weighted imaging (DWI) occur in one-third of intracerebral hemorrhage (ICH). Due to conflicting prior studies, it is uncertain if the degree of systolic bloodpressure reduction increases the risk. Stroke, Volume 55, Issue Suppl_1 , Page ATP154-ATP154, February 1, 2024.
Background:Ischemia on diffusion weighted imaging (DWI) after intracerebral hemorrhage (ICH) increases the risk of future ischemic stroke. Though cortical superficial siderosis (cSS) is also a hemorrhagic small vessel disease subtype, it is unclear if cSS similarly relates to DWI lesions. and cSS in 10.6%.
Introduction:While the attention on racial, ethnic, and gender differences in ischemic stroke has progressed beyond reporting to evaluating corrective activities, less is known about disparities in hemorrhagic stroke evaluation and care, especially amongst young population. More women had access to primary care compared to men (51.2%
Also consider non-hemorrhagic volume depletion, dehydration : orthostatic vitals may uncover this [see Mendu et al. (3)]. Cardiac Syncope ("True Syncope") Independent Predictors of Adverse Outcomes condensed from multiple studies 1. These premonitory symptoms were negative predictors of adverse outcomes in EGSYS.
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