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Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation

Journal of Clinical Investigation - Cardiology

How these conditions are linked mechanistically remains unclear, especially two of these: obesity and elevated blood pressure. Pharmacological prevention of lipid droplet formation reverses the suppression of NO production in cell culture and in vivo and blunts blood pressure elevation in response to a high-fat diet.

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Rivus HU6 Shows Obesity-HFpEF Potential

CardiacWire

Rivus Pharmaceuticals’ HU6 is showing promise as a future obesity-related HFpEF treatment, after topline results from its Phase 2a HuMAIN trial revealed valuable weight, symptom, and cardiometabolic improvements – without the risk of muscle loss. blood pressure, pulse, glucose control, inflammation, lipid levels, and liver enzymes).

Obesity 52
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Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II

Journal of the American Heart Association

BackgroundWe have previously reported that male mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show sympathetic activation and increased blood pressure in response to a chronic high‐fat diet. Angiotensin peptides in serum were similar in control and MSEW mice regardless of the diet.

Obesity 40
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Should You Take Ozempic To Lose Weight?

Dr. Paddy Barrett

Overweight/Obesity. Falling into the class of obesity with a BMI of greater than 30 makes this more likely, but so also does having excess visceral fat deposition with significant metabolic consequences at a BMI less than 30. They are not crash diets to fit into your swimwear. All diets work. For a while.

Obesity 52
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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52
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Revolutionary Results: How Modern Weight Loss Medications are Changing the Game

Dr. Paddy Barrett

That’s what the field of obesity therapeutics feels like right now. Share In addition to reductions in weight, multiple risk parameters, including blood pressure, waist circumference and lipids, also improve. What seems clear, however, is that a higher protein diet minimises the degree of lean mass loss 8.

Obesity 87
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The Importance of Cardiovascular Health: An Overview

GEMMS

Regular exercise, a balanced diet, and lifestyle choices such as not smoking and managing stress are all crucial for achieving and maintaining optimal cardiovascular health. Maintaining cardiovascular health reduces the risk of developing various heart diseases, including heart attack, stroke, and high blood pressure.