Frontiers in Cardiovascular Medicine
JANUARY 23, 2024
Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. These biomarkers are typically linked to complications from HTX.
Frontiers in Cardiovascular Medicine
FEBRUARY 5, 2024
Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). cfDNA markers can be used for the detection of cGVHD, opening a window into underlying tissue dynamics in patients that receive allogeneic stem cell transplants. BACKGROUND.
Frontiers in Cardiovascular Medicine
APRIL 8, 2024
To improve our understanding of BAV pathogenesis, we characterized the cellular composition of BAV tissues and identified molecular changes in each cell population.MethodsTissue samples from two patients with BAV and two heart transplant donors were analyzed using single-cell RNA sequencing, assay for transposase-accessible chromatin using sequencing, (..)
Circulation: Heart Failure
JANUARY 16, 2025
However, no biomarker reflecting RVD is available for routine clinical use.METHODS:Proteomic analysis of myocardium from the left ventricle and right ventricle (RV) of patients with heart failure with reduced ejection fraction with (n=10) and without RVD (n=10) who underwent heart transplantation was performed.
HeartRhythm
APRIL 30, 2024
Investigating miRNA changes in TIC could aid in developing novel therapies and serve as biomarkers, aiming to reduce heart failure and transplantation burdens. Micro RNAs (miRNAs) are small, non-coding RNAs that function to regulate gene expression.
DAIC
FEBRUARY 2, 2024
Food and Drug Administration: How to Keep Pace With New Drug Development and Drug Safety” by Laleh Amiri Kordestani, MD Panel Discussion - Patient-Focused Drug Development with Moderator: Ana Barac, MD, PhD, FACC, and panelists Julia Maues and Patient Voice from Asma Dilawari, MD Immunotherapy Decoding Immunotherapy: Applying Diagnostic Criteria (..)
Expert insights. Personalized for you.
119 
Let's personalize your content