Medical Xpress - Cardiology

MAY 1, 2024

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

Cerebrovascular Disease 97

Cerebrovascular Disease Biomarkers Strokes Stroke 97

DAIC

DECEMBER 13, 2023

MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE. When they break loose, they can be deadly, triggering strokes and heart attacks.

Heart Attack 105

Heart Attack Heart attacks Atherosclerosis Strokes 105

Journal of the American Heart Association

FEBRUARY 13, 2024

BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Journal of the American Heart Association, Ahead of Print.

Biomarkers 72

Biomarkers Strokes Stroke Myocardial Infarction 72

Journal of the American Heart Association

FEBRUARY 23, 2024

We aimed to evaluate the association of 3 cardiac biomarkers in combination with poststroke cognitive impairment and their prognostic significance.Methods and ResultsThis prospective study included 566 patients with ischemic stroke. 4.07) and 1.86 (1.10–3.14) 4.07) and 1.86 (1.10–3.14)

Biomarkers 45

Biomarkers Strokes Stroke Risk Factors 45

HeartRhythm

MARCH 6, 2025

Detecting atrial fibrillation (AF) after a stroke of undetermined source is crucial to providing appropriate secondary prevention and reducing the risk of a subsequent secondary event. Current guidelines advocate for extended monitoring in these patients.1,2 Current guidelines advocate for extended monitoring in these patients.1,2

Biomarkers 40

Biomarkers Atrial Fibrillation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase.

Biomarkers 40

Biomarkers Strokes Stroke Technology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025. Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical.

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

DAIC

FEBRUARY 1, 2024

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Peripheral Arterial Disease Strokes 104

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP32-AWMP32, February 1, 2025. Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). fold change and unadjusted p-value <0.05

Biomarkers 40

Biomarkers Strokes Stroke Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP396-AWP396, February 1, 2025. Pre-clinical rodent studies have identified angiopoietins, their subvariants, and receptor Tie2 in regulating collateral function and vascular remodeling following ischemic stroke.

Biomarkers 40

Biomarkers Strokes Stroke 40

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system.

Plaque 52

Plaque Biomarkers Circulation Stenosis 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A33-A33, February 1, 2025. Introduction:Net water uptake (NWU) is a novel biomarker which measures edema and tissue injury from the degree of hypoattenuation on non-contrast CT and may serve as a precision tool for predicting outcomes after acute ischemic stroke (AIS).

Biomarkers 40

Biomarkers Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP245-ATP245, February 1, 2024. Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. Accurate identification of stroke etiology is vital for secondary stroke prevention. had hyperlipidemia.

Biomarkers 40

Biomarkers Strokes Stroke Atherosclerosis 40

Cardiovascular Diabetology

MARCH 25, 2025

C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, the association between CTI and the risk of stroke, particularly in.

Biomarkers 52

Biomarkers Strokes Stroke Research 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A64-A64, February 1, 2024. Background:Atrial cardiopathy is associated with incident ischemic stroke in the absence of clinical atrial fibrillation in prospective cohorts. Recurrent stroke occurred in 80 patients (annualized rate, 4.4%) and death in 54 patients. female, 21.1% Black, and 8.1%

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).

Biomarkers 40

Biomarkers Circulation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A146-A146, February 1, 2025. Introduction:Patients with transient ischemic attack (TIA) and those with stroke mimics (MIM) are often difficult to distinguish in emergency room (ER) settings. While TIA patients are at an increased risk of stroke, MIM do not need stroke-related management.

Biomarkers 40

Biomarkers Strokes Stroke 40

CardiacWire

FEBRUARY 7, 2025

Researchers were not able to assess unmeasured confounding factors such as biomarker levels, socioeconomic factors, nursing care level, and medication adherence. Weekend patients were hospitalized twice as long (8 vs. 4 days), costing hospitals almost $28,000 more per patient ($249k vs. $222.9k).

TAVR 59

TAVR Cardiogenic Shock Hospital Cardiac Arrest 59

Stroke Journal

MARCH 24, 2024

Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. This review highlights pathways that are aiding the search for sensitive and specific blood-based cerebrovascular dysfunction markers, describes promising candidates, and explains ongoing initiatives to discover blood-based VCID biomarkers.

Biomarkers 40

Biomarkers Dementia Hemorrhage Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.

Biomarkers 40

Biomarkers Strokes Stroke Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP275-AWP275, February 1, 2024. Introduction:Elezanumab (EZB), a monoclonal antibody specific to repulsive guidance molecule A (RGMa), is under investigation to treat acute ischemic stroke. Blood samples were taken post-stroke across 52 weeks, or 1 time (baseline) for healthy adults.

Biomarkers 40

Biomarkers Strokes Stroke 40

Journal of the American Heart Association

NOVEMBER 28, 2023

BackgroundComplex aortic plaque (CAP) is a potential embolic source in patients with cryptogenic stroke (CS). From 2293 studies, 45 were reviewed for CAP imaging biomarker criteria in patients with acute CS (N=37 TEE; N=9 CTA; N=6 magnetic resonance imaging). The most common CAP imaging biomarker was ≥4 mm plaque thickness.

Plaque 40

Plaque Biomarkers Aortic Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP283-ATP283, February 1, 2024. Objectives:The dynamic evolution of ischemic penumbra to core has implications for stroke outcomes. Serum H3K18la variations emerge as potential indicators of neuronal damage severity, suggesting effective biomarkers for assessing post-stroke prognosis.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025. A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.

Biomarkers 40

Biomarkers Aneurysm Cardiomyopathy Hemorrhage 40

Stroke Journal

FEBRUARY 7, 2024

Stroke, Ahead of Print. Background:Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo.

Biomarkers 40

Biomarkers Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025. Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition. This difference was more pronounced among females.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

Frontiers in Cardiovascular Medicine

MARCH 25, 2025

We analyzed SUA concentration and lipid profile, along with relevant clinical data, to assess their impact on the occurrence of ischemic stroke (IS) in NAF patients. KaplanMeier cumulative risk analysis indicates that a gender-based combined assessment of SUA and TG enhances stroke risk stratification in NAF patients.

Atrial Fibrillation 52

Atrial Fibrillation Strokes Stroke Biomarkers 52

Stroke Journal

JANUARY 26, 2025

Stroke, Volume 56, Issue 2 , Page 475-477, February 1, 2025.

Strokes 40

Strokes Stroke Biomarkers 40

Stroke Journal

MARCH 6, 2024

Stroke, Ahead of Print. Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the elderly services, and undiagnosed in the community. Neuroimaging has a major role in identifying the proportion of vascular versus other likely pathologies in patients with cognitive impairment.

Biomarkers 40

Biomarkers Dementia Strokes Stroke 40

Cardiovascular Diabetology

DECEMBER 12, 2023

This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing.

Hypertension 52

Hypertension Strokes Stroke Biomarkers 52

DAIC

MARCH 7, 2024

Patients treated with CardiAMP cell therapy saw an almost 5% lower rate of heart death equivalents at up to two years compared to control patients treated with heart failure medication alone (8.3% vs. 13.2%, respectively).

Heart Failure 105

Heart Failure Biomarkers Reimbursement CMS 105

Stroke Journal

MARCH 6, 2024

Stroke, Ahead of Print. BACKGROUND:The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Stroke Journal

FEBRUARY 5, 2025

Stroke, Ahead of Print. Serum analysis revealed rGDF11 dose-dependent decreases in C-reactive protein and identified novel pharmacodynamic biomarkers and pathways associated with potential mechanisms of action of rGDF11.Conclusion:These

Ischemia 45

Ischemia Strokes Stroke Biomarkers 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP49-ATP49, February 1, 2025. Background:Small vessel cerebral vascular disease (sCVD) is common to older individuals, often asymptomatic, but associated with incident stroke and future mortality. years of education. Future work will associate these findings with sCVD phenotypes.

Biomarkers 40

Biomarkers Education Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP44-ATP44, February 1, 2025. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. This secondary study aims to describe the association between the N20 response and imaging biomarkers of ischemic penumbra, infarct volume and collateral flow.MethodsPresence and amplitude of the N20 response was recorded before EVT.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP227-AWP227, February 1, 2025. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. These biomarkers could facilitate timely interventions, potentially improving outcomes for stroke patients.

Biomarkers 40

Biomarkers Physiology Hemorrhage Strokes 40