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Biomarkers Stroke Strokes 
Stroke Journal
MARCH 14, 2025
Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking.
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Science Daily - Heart Disease
MAY 1, 2024
A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new study.
Science Daily - Stroke
JANUARY 30, 2025
Shorter protective caps on chromosomes called telomeres, a proposed marker of accelerated biological cell aging, may be associated with an increased risk of stroke, dementia and late-life depression, according to an analysis of more than 356,000 people in the United Kingdom.
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Frontiers in Cardiovascular Medicine
FEBRUARY 13, 2025
Biomarkers commonly used in both silicosis and cardiovascular diseases were reviewed to underline the common pathological pathways.ResultsPublished epidemiological data revealed a higher risk of ischemic heart disease, stroke, and hypertension in silica-exposed workers, even at low exposure levels.
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Journal of the American Heart Association, Ahead of Print.
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Open Heart
JANUARY 31, 2025
EE from vegetation rupture are frequent, occurring in more than 50% of patients and can lead to ischaemic stroke and systemic organ infarctions, contributing to poor patient outcomes.
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Medical Xpress - Cardiology
MAY 1, 2024
A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.
Journal of the American Heart Association
FEBRUARY 23, 2024
We aimed to evaluate the association of 3 cardiac biomarkers in combination with poststroke cognitive impairment and their prognostic significance.Methods and ResultsThis prospective study included 566 patients with ischemic stroke. 4.07) and 1.86 (1.10–3.14) 4.07) and 1.86 (1.10–3.14)
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase.
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Stroke Journal
MARCH 28, 2025
Stroke, Ahead of Print. This investigation describes the prevalence, risk factors, and outcomes associated with FVH in pediatric arterial ischemic stroke (AIS).METHODS:Retrospective METHODS:Retrospective review of children aged 29 days to 18 years in a single institution stroke registry from 2006 to 2022 with AIS.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025. Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical.
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Stroke Journal
MARCH 20, 2025
Stroke, Ahead of Print. BACKGROUND:Sex and social determinants of health predict stroke, yet few studies focus exclusively on women at high social risk. We identified stroke from electronic health records during the 2.5-year Nine (3.8%) participants had documented strokes.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP32-AWMP32, February 1, 2025. Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). fold change and unadjusted p-value <0.05
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP396-AWP396, February 1, 2025. Pre-clinical rodent studies have identified angiopoietins, their subvariants, and receptor Tie2 in regulating collateral function and vascular remodeling following ischemic stroke.
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HeartRhythm
MARCH 6, 2025
Detecting atrial fibrillation (AF) after a stroke of undetermined source is crucial to providing appropriate secondary prevention and reducing the risk of a subsequent secondary event. Current guidelines advocate for extended monitoring in these patients.1,2 Current guidelines advocate for extended monitoring in these patients.1,2
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP245-ATP245, February 1, 2024. Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. Accurate identification of stroke etiology is vital for secondary stroke prevention. had hyperlipidemia.
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Cardiovascular Diabetology
MARCH 25, 2025
C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, the association between CTI and the risk of stroke, particularly in.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A33-A33, February 1, 2025. Introduction:Net water uptake (NWU) is a novel biomarker which measures edema and tissue injury from the degree of hypoattenuation on non-contrast CT and may serve as a precision tool for predicting outcomes after acute ischemic stroke (AIS).
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Frontiers in Cardiovascular Medicine
MARCH 25, 2025
We analyzed SUA concentration and lipid profile, along with relevant clinical data, to assess their impact on the occurrence of ischemic stroke (IS) in NAF patients. KaplanMeier cumulative risk analysis indicates that a gender-based combined assessment of SUA and TG enhances stroke risk stratification in NAF patients.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A146-A146, February 1, 2025. Introduction:Patients with transient ischemic attack (TIA) and those with stroke mimics (MIM) are often difficult to distinguish in emergency room (ER) settings. While TIA patients are at an increased risk of stroke, MIM do not need stroke-related management.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.
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Stroke Journal
JANUARY 26, 2025
Stroke, Volume 56, Issue 2 , Page 475-477, February 1, 2025.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025. Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition. This difference was more pronounced among females.
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Cardiovascular Diabetology
DECEMBER 12, 2023
This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing.
52 Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP275-AWP275, February 1, 2024. Introduction:Elezanumab (EZB), a monoclonal antibody specific to repulsive guidance molecule A (RGMa), is under investigation to treat acute ischemic stroke. Blood samples were taken post-stroke across 52 weeks, or 1 time (baseline) for healthy adults.
40 Stroke Journal
FEBRUARY 7, 2024
Stroke, Ahead of Print. Background:Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo.
40 Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset. pg/mL, respectively.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP16-ADP16, February 1, 2025. Introduction:The National Institutes of Health Stroke Scale (NIHSS) provides a clinical measure of stroke severity. We collected blood from each patient at hospital admission before administering any therapeutic intervention.
40 Journal of the American Heart Association
NOVEMBER 28, 2023
BackgroundComplex aortic plaque (CAP) is a potential embolic source in patients with cryptogenic stroke (CS). From 2293 studies, 45 were reviewed for CAP imaging biomarker criteria in patients with acute CS (N=37 TEE; N=9 CTA; N=6 magnetic resonance imaging). The most common CAP imaging biomarker was ≥4 mm plaque thickness.
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Frontiers in Cardiovascular Medicine
APRIL 24, 2024
The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP101-AWMP101, February 1, 2025. Introduction:The ARCADIA trial (Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy) found no benefit of anticoagulation for secondary stroke prevention in patients with cryptogenic stroke and evidence of atrial cardiopathy.
40 Stroke Journal
JANUARY 18, 2024
Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATMP9-ATMP9, February 1, 2024. Background:FLAIR vascular hyperintensities (FVH) are high signal intensities on MRI resulting from sluggish flow through collateral vessels in patients with acute arterial ischemic stroke (AIS). Data from adults suggest they may be a marker of penumbra.
40 Medical Xpress - Cardiology
SEPTEMBER 3, 2024
Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischemic stroke or systemic embolism (blood clot) in older adults aged 75–76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug–2 Sept).
Stroke Journal
MARCH 24, 2024
Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. This review highlights pathways that are aiding the search for sensitive and specific blood-based cerebrovascular dysfunction markers, describes promising candidates, and explains ongoing initiatives to discover blood-based VCID biomarkers.
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Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. This secondary study aims to describe the association between the N20 response and imaging biomarkers of ischemic penumbra, infarct volume and collateral flow.MethodsPresence and amplitude of the N20 response was recorded before EVT.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATMP58-ATMP58, February 1, 2024. Objectives:To determine the relationship between patient-reported outcome measures (PROMs) and volumetric biomarkers assessed on clinical imaging in acute ischemic stroke (AIS).Background:AIS Background:AIS is a leading cause of long-term disability.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP320-ATP320, February 1, 2025. The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear. The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear. <0.1).
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP385-ATP385, February 1, 2025. Emerging research suggests that Vitamin D3 might help protect against brain damage caused by ischemic stroke, as a deficiency in Vitamin D3 can worsen the severity and outcomes of a stroke.
40 Stroke Journal
DECEMBER 14, 2023
Stroke, Ahead of Print. BACKGROUND:Iron status has been associated with functional outcomes after ischemic stroke (IS). This data set included 4 iron status biomarkers, namely, ferritin, total iron binding capacity, iron, and transferrin saturation (TSAT). Nonetheless, this association may be affected by confounders.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines. Of 25 enrolled patients, mean age was 65.8 (SD,
40 Stroke Journal
MARCH 24, 2024
Stroke, Volume 55, Issue 4 , Page e131-e131, April 1, 2024.
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Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe routinely used computed tomography (CT)‐based workup in the setting of acute ischemic stroke (AIS) includes non‐contrast brain CT, CT angiography (CTA), and CT perfusion.
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