Stroke Journal

MARCH 27, 2025

Stroke, Ahead of Print. Stroke remains a predominant cause of death and long-term disability among adults worldwide. We focus on their potential as biomarkers for recovery management and as novel treatment targets that may enhance neuronal repair and mitigate secondary neurodegeneration.

Biomarkers 40

Biomarkers Stroke Strokes Quality of Life 40

Journal of the American Heart Association

FEBRUARY 13, 2024

BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Journal of the American Heart Association, Ahead of Print.

Biomarkers 72

Biomarkers Stroke Strokes Myocardial Infarction 72

Medical Xpress - Cardiology

MAY 1, 2024

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

Cerebrovascular Disease 97

Cerebrovascular Disease Biomarkers Stroke Strokes 97

Open Heart

JANUARY 31, 2025

EE from vegetation rupture are frequent, occurring in more than 50% of patients and can lead to ischaemic stroke and systemic organ infarctions, contributing to poor patient outcomes.

Embolism 52

Embolism Biomarkers Heart Failure Risk Factors 52

HeartRhythm

MARCH 6, 2025

Detecting atrial fibrillation (AF) after a stroke of undetermined source is crucial to providing appropriate secondary prevention and reducing the risk of a subsequent secondary event. Current guidelines advocate for extended monitoring in these patients.1,2 Current guidelines advocate for extended monitoring in these patients.1,2

Biomarkers 40

Biomarkers Atrial Fibrillation Stroke Strokes 40

Journal of the American Heart Association

FEBRUARY 23, 2024

We aimed to evaluate the association of 3 cardiac biomarkers in combination with poststroke cognitive impairment and their prognostic significance.Methods and ResultsThis prospective study included 566 patients with ischemic stroke. 4.07) and 1.86 (1.10–3.14) 4.07) and 1.86 (1.10–3.14)

Biomarkers 45

Biomarkers Stroke Strokes Risk Factors 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase. Moreover, it is unclear what effective therapeutic targets as well as molecular systemic changes in stroke in the chronic phase.

Biomarkers 40

Biomarkers Stroke Strokes Technology 40

Stroke Journal

MARCH 28, 2025

Stroke, Ahead of Print. This investigation describes the prevalence, risk factors, and outcomes associated with FVH in pediatric arterial ischemic stroke (AIS).METHODS:Retrospective METHODS:Retrospective review of children aged 29 days to 18 years in a single institution stroke registry from 2006 to 2022 with AIS.

Pediatrics 40

Pediatrics Biomarkers Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025. Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical.

Hemorrhage 40

Hemorrhage Biomarkers Stroke Strokes 40

Cardiovascular Diabetology

MARCH 25, 2025

C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, the association between CTI and the risk of stroke, particularly in.

Biomarkers 52

Biomarkers Stroke Strokes Research 52

Stroke Journal

MARCH 20, 2025

Stroke, Ahead of Print. BACKGROUND:Sex and social determinants of health predict stroke, yet few studies focus exclusively on women at high social risk. We identified stroke from electronic health records during the 2.5-year Nine (3.8%) participants had documented strokes.

Stroke 49

Stroke Strokes Risk Factors Document 49

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP32-AWMP32, February 1, 2025. Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). fold change and unadjusted p-value <0.05

Biomarkers 40

Biomarkers Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP396-AWP396, February 1, 2025. Pre-clinical rodent studies have identified angiopoietins, their subvariants, and receptor Tie2 in regulating collateral function and vascular remodeling following ischemic stroke.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP245-ATP245, February 1, 2024. Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. Accurate identification of stroke etiology is vital for secondary stroke prevention. had hyperlipidemia.

Biomarkers 40

Biomarkers Stroke Strokes Atherosclerosis 40

Frontiers in Cardiovascular Medicine

MARCH 25, 2025

We analyzed SUA concentration and lipid profile, along with relevant clinical data, to assess their impact on the occurrence of ischemic stroke (IS) in NAF patients. KaplanMeier cumulative risk analysis indicates that a gender-based combined assessment of SUA and TG enhances stroke risk stratification in NAF patients.

Atrial Fibrillation 52

Atrial Fibrillation Stroke Strokes Biomarkers 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A64-A64, February 1, 2024. Background:Atrial cardiopathy is associated with incident ischemic stroke in the absence of clinical atrial fibrillation in prospective cohorts. Recurrent stroke occurred in 80 patients (annualized rate, 4.4%) and death in 54 patients. female, 21.1% Black, and 8.1%

Biomarkers 40

Biomarkers Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A33-A33, February 1, 2025. Introduction:Net water uptake (NWU) is a novel biomarker which measures edema and tissue injury from the degree of hypoattenuation on non-contrast CT and may serve as a precision tool for predicting outcomes after acute ischemic stroke (AIS).

Biomarkers 40

Biomarkers Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).

Biomarkers 40

Biomarkers Circulation Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A146-A146, February 1, 2025. Introduction:Patients with transient ischemic attack (TIA) and those with stroke mimics (MIM) are often difficult to distinguish in emergency room (ER) settings. While TIA patients are at an increased risk of stroke, MIM do not need stroke-related management.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.

Biomarkers 40

Biomarkers Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 26, 2025

Stroke, Volume 56, Issue 2 , Page 475-477, February 1, 2025.

Stroke 40

Stroke Strokes Biomarkers 40

CardiacWire

FEBRUARY 7, 2025

Researchers were not able to assess unmeasured confounding factors such as biomarker levels, socioeconomic factors, nursing care level, and medication adherence. Weekend patients were hospitalized twice as long (8 vs. 4 days), costing hospitals almost $28,000 more per patient ($249k vs. $222.9k).

TAVR 59

TAVR Cardiogenic Shock Hospital Cardiac Arrest 59

Stroke Journal

FEBRUARY 5, 2025

Stroke, Ahead of Print. Serum analysis revealed rGDF11 dose-dependent decreases in C-reactive protein and identified novel pharmacodynamic biomarkers and pathways associated with potential mechanisms of action of rGDF11.Conclusion:These

Ischemia 45

Ischemia Stroke Strokes Biomarkers 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025. Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition. This difference was more pronounced among females.

Biomarkers 40

Biomarkers Stroke Strokes Outcomes 40

Cardiovascular Diabetology

DECEMBER 12, 2023

This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing.

Hypertension 52

Hypertension Stroke Strokes Biomarkers 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP275-AWP275, February 1, 2024. Introduction:Elezanumab (EZB), a monoclonal antibody specific to repulsive guidance molecule A (RGMa), is under investigation to treat acute ischemic stroke. Blood samples were taken post-stroke across 52 weeks, or 1 time (baseline) for healthy adults.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 7, 2024

Stroke, Ahead of Print. Background:Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP283-ATP283, February 1, 2024. Objectives:The dynamic evolution of ischemic penumbra to core has implications for stroke outcomes. Serum H3K18la variations emerge as potential indicators of neuronal damage severity, suggesting effective biomarkers for assessing post-stroke prognosis.

Biomarkers 40

Biomarkers Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset. pg/mL, respectively.

Stroke 40

Stroke Strokes Circulation Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP16-ADP16, February 1, 2025. Introduction:The National Institutes of Health Stroke Scale (NIHSS) provides a clinical measure of stroke severity. We collected blood from each patient at hospital admission before administering any therapeutic intervention.

Stroke 40

Stroke Strokes Biomarkers Hospital 40

Journal of the American Heart Association

NOVEMBER 28, 2023

BackgroundComplex aortic plaque (CAP) is a potential embolic source in patients with cryptogenic stroke (CS). From 2293 studies, 45 were reviewed for CAP imaging biomarker criteria in patients with acute CS (N=37 TEE; N=9 CTA; N=6 magnetic resonance imaging). The most common CAP imaging biomarker was ≥4 mm plaque thickness.

Plaque 40

Plaque Biomarkers Aortic Stroke 40

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system.

Plaque 52

Plaque Circulation Biomarkers Stenosis 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP101-AWMP101, February 1, 2025. Introduction:The ARCADIA trial (Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy) found no benefit of anticoagulation for secondary stroke prevention in patients with cryptogenic stroke and evidence of atrial cardiopathy.

Biomarkers 40

Biomarkers Cardiomyopathy Stroke Strokes 40

Stroke Journal

JANUARY 18, 2024

Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.

Dementia 90

Dementia Cerebrovascular Disease Biomarkers Stroke 90

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP9-ATMP9, February 1, 2024. Background:FLAIR vascular hyperintensities (FVH) are high signal intensities on MRI resulting from sluggish flow through collateral vessels in patients with acute arterial ischemic stroke (AIS). Data from adults suggest they may be a marker of penumbra.

Pediatrics 40

Pediatrics Biomarkers Stroke Strokes 40

HeartRhythm

APRIL 30, 2024

Stroke continues to be a leading cause of death worldwide despite improvements in prevention and treatment. Novel biomarkers have been proposed to improve the accuracy of stroke risk assessment including electrocardiographic (ECG)-age, which has been shown to predict clinical outcomes.

Stroke 40

Stroke Strokes Biomarkers Outcomes 40

Medical Xpress - Cardiology

SEPTEMBER 3, 2024

Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischemic stroke or systemic embolism (blood clot) in older adults aged 75–76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug–2 Sept).

Atrial Fibrillation 40

Atrial Fibrillation Blood Clot Research Embolism 40