HCPLive

NOVEMBER 18, 2024

Panelists discuss potential biomarkers and clinical indicators that can aid in predicting disease outcomes for individual patients with IgA nephropathy.

Biomarkers 52

Biomarkers Outcomes 52

Frontiers in Cardiovascular Medicine

JANUARY 31, 2024

Objective In patients with complex coronary artery disease (CAD) undergoing cardiac surgery, myocardial protection might be impaired due to microvascular obstruction, resulting in myocardial injury and subsequent biomarker release. Preoperatively, higher levels of cardiac biomarkers were found in patients with higher SYNTAX Score II.

Coronary Artery Disease 64

Coronary Artery Disease Biomarkers Outcomes 64

Heart BMJ

AUGUST 26, 2024

1 Supporting evidence of elevated inflammatory biomarkers and findings of pericardial inflammation on cardiac magnetic resonance or CT also play critical roles in its evaluation.

Pericarditis 105

Pericarditis Chest Pain Outcomes Biomarkers 105

HCPLive

JANUARY 23, 2024

Wesley Mizutani, MD, discusses California's SB 496 legislation, which addresses the crucial role of biomarkers in guiding optimal drug selection to improve overall healthcare outcomes.

Biomarkers 59

Biomarkers Outcomes 59

Journal of Clinical Investigation - Cardiology

APRIL 1, 2024

There is unmet need for additional biomarkers to better select patients with non–small cell lung cancer (NSCLC) that are likely to benefit from immunotherapy in order to improve patient outcomes, reduce patient toxicity, and relieve the growing burden of healthcare costs.

Biomarkers 58

Biomarkers Cancer Outcomes 58

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

Furthermore, we highlight how recent trends in prescription of GLP-1 receptor antagonists are serving to motivate patients to manage biomarkers related to T2D and obesity, which are also relevant in cardiovascular disease.

Cardiovascular Disease 52

Cardiovascular Disease Biomarkers Obesity Outcomes 52

Frontiers in Cardiovascular Medicine

FEBRUARY 11, 2024

In this review, we summarize the diagnostic and prognostic tools for ICI-myocarditis, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, with emphasis on circulating biomarkers.

Biomarkers 64

Biomarkers Circulation Cancer Outcomes 64

HCPLive

AUGUST 16, 2024

Strnad explains the need for noninvasive biomarkers in AATD liver disease and early research about circulating Z-polymer’s potential association with clinically relevant adverse outcomes.

Biomarkers 52

Biomarkers Circulation Research Outcomes 52

Frontiers in Cardiovascular Medicine

NOVEMBER 25, 2024

Future research should focus on understanding the mechanisms behind pathological transdifferentiation, identifying relevant biomarkers and master regulators, and developing novel therapies through preclinical and clinical trials.

Cardiovascular Disease 59

Cardiovascular Disease Biomarkers Research Outcomes 59

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2024

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies.

Myocardial Infarction 52

Myocardial Infarction Physiology Biomarkers Innovation 52

Heart BMJ

MAY 10, 2024

A timely diagnosis and initiation of evidence-based treatments are key to prevent hospitalisation and improve outcomes in this population. Biomarkers have dramatically impacted the way patients with HF are evaluated and managed. The most studied biomarkers in HF are natriuretic peptides (NPs).

Biomarkers 52

Biomarkers Heart Failure Physiology Article 52

DAIC

MARCH 25, 2025

Ten presentations will feature new data from the pivotal Phase III FINEARTS-HF cardiovascular (CV) outcomes trial, which investigated KERENDIA for treatingt adult patients with heart failure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF). Additional ACC.25

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Kidney Disease Research 52

HeartRhythm

AUGUST 25, 2024

Neurofilament light chain (NFL) protein is a biomarker for neurodegenerative diseases. Atrial fibrillation (AF) is an age-related disorder closely linked to autonomic nervous system dysfunction.

Atrial Fibrillation 81

Atrial Fibrillation Biomarkers Ablation Outcomes 81

Stroke Journal

JANUARY 30, 2025

Introduction:Net water uptake (NWU) is a novel biomarker which measures edema and tissue injury from the degree of hypoattenuation on non-contrast CT and may serve as a precision tool for predicting outcomes after acute ischemic stroke (AIS). When controlling for confounders, NWU was non-inferior to ASPECTS.

Biomarkers 40

Biomarkers Outcomes Strokes Stroke 40

Journal of Cardiothoracic Surgery

FEBRUARY 4, 2025

The aim of this review is to summarize the literature concerning the prognostic ability of various preoperative biomarkers for patien. Aortic dissections and repairs are associated with high rates of mortality.

Biomarkers 40

Biomarkers Aortic Outcomes 40

Circulation: Cardiovascular Quality & Outcomes

JANUARY 19, 2024

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Background:Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM).Methods:This

Biomarkers 40

Biomarkers Sudden Cardiac Death Coronary Artery Bypass Graft Cardiomyopathy 40

NEJM Journal Watch - Cardiology

AUGUST 29, 2024

Yes, but proving unequivocally that these measurements — added to clinical assessment — improve outcomes is still a work in progress.

Biomarkers 68

Biomarkers Outcomes 68

Stroke Journal

FEBRUARY 1, 2024

Results:Univariate analysis unveiled candidate molecules predictive of outcomes. Multivariate combinatory linear discriminant analysis (LDA) demonstrated significant prognostic potential for favorable outcomes.

Biomarkers 40

Biomarkers Outcomes Aneurysm Hemorrhage 40

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

By leveraging ML technology, healthcare professionals can make informed decisions and implement timely interventions, ultimately leading to improved outcomes and potentially reducing the mortality rate associated with coronary artery disease. Incorporating 65 new sensitive cytokine biomarkers can increase early detection even more.

Coronary Artery Disease 111

Coronary Artery Disease Biomarkers Technology Outcomes 111

Stroke Journal

MARCH 27, 2025

We focus on their potential as biomarkers for recovery management and as novel treatment targets that may enhance neuronal repair and mitigate secondary neurodegeneration.

Biomarkers 40

Biomarkers Strokes Stroke Quality of Life 40

Stroke Journal

JANUARY 30, 2025

Background:Endovascular thrombectomy (EVT) dramatically improves clinical outcomes, but the final infarct volume (FIV) on MRI only accounts for a minority of the treatment effect. Good outcome was defined as 2 on the 90-day modified Rankin Scale. The mean age was 69 13 years, 41% were female, and 62% achieved a good outcome.

Biomarkers 40

Biomarkers Outcomes Circulation Strokes 40

Stroke Journal

JANUARY 30, 2025

4.94), but not with 90-day mRS or mortality.Conclusion:Serum creatinine-based biomarkers of renal dysfunction were associated with faster progressor phenotype of ACLVO stroke, higher mRS, and mortality at 90 days. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).

Biomarkers 40

Biomarkers Circulation Strokes Stroke 40

DAIC

MARCH 7, 2024

Despite improvements with current medications and devices, heart failure remains at epidemic proportions and we now have an exciting opportunity for a therapy to improve important, objective outcomes, such as mortality and hospital re-admissions rates. “We

Heart Failure 105

Heart Failure Biomarkers Reimbursement CMS 105

Stroke Journal

JANUARY 30, 2025

Introduction:Endovascular thrombectomy (EVT) dramatically improves clinical outcomes, but the reduction in final infarct volume only accounts for a minority of the treatment effect. Good functional outcome was defined as a 90-day modified Rankin Scale score 2. MRI was performed 1248 hours post-EVT. vs 30.3%, p<0.0001).Table

Biomarkers 40

Biomarkers Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Background:Atrial cardiopathy is associated with incident ischemic stroke in the absence of clinical atrial fibrillation in prospective cohorts. We analyzed the full cohort using Cox proportional hazard models , sequentially adjusting for treatment effect, demographic factors, and clinical risk factors.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

DAIC

APRIL 9, 2024

The PROACT study reported no impact on cardiotoxicity biomarkers or secondary endpoints related to heart function among patients who took high doses of enalapril, an ACE inhibitor, along with high doses of anthracyclines. The PROACT study will continue to track outcomes in the study participants for at least 12 months.

ACE Inhibitor 105

ACE Inhibitor Cancer Biomarkers Heart Failure 105

Open Heart

OCTOBER 31, 2024

Results Baseline characteristics revealed significant differences between NUA and HUA groups, with the latter exhibiting a higher prevalence of males, chronic kidney disease (CKD) and elevated levels of various biomarkers. Our findings suggest that monitoring and managing SUA could be crucial in improving patient with HF outcomes.

Heart Failure 52

Heart Failure Kidney Disease Blood Pressure Biomarkers 52

Journal of the American Heart Association

FEBRUARY 13, 2024

BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Journal of the American Heart Association, Ahead of Print.

Biomarkers 72

Biomarkers Strokes Stroke Myocardial Infarction 72

Stroke Journal

JANUARY 30, 2025

Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical. The study found that GFAP levels were significantly higher in HS patients, particularly among those with fatal outcomes. Survivors had GFAP levels of 1.35

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

These outcomes are driven by inflammatory processes. Given the pivotal role of inflammatory mediators in the pathogenesis of aortic calcification, inflammation has attracted interest as a peripheral biomarker for early mortality prediction in patients with aortic calcification.

Aortic 52

Aortic Atherosclerosis Laboratory Biomarkers 52

Journal of the American Heart Association

JANUARY 12, 2024

Biomarkers were measured in a median of 16 repeated samples per individual. Cluster analysis was performed to identify biomarker‐based subphenotypes in 723 patients without a repeat ACS in the first year. The temporal biomarker patterns of patients in cluster 3 were similar to those with a repeat ACS during the first year.

Biomarkers 40

Biomarkers Outcomes 40

HCPLive

JULY 30, 2024

Greater circulating Z-polymer levels were associated with an increased risk of adverse clinical outcomes in adults with AATD and the PiZZ genotype.

Circulation 52

Circulation Biomarkers Outcomes 52

Stroke Journal

JANUARY 30, 2025

Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. These biomarkers could facilitate timely interventions, potentially improving outcomes for stroke patients.

Biomarkers 40

Biomarkers Physiology Hemorrhage Strokes 40

Stroke Journal

JANUARY 30, 2025

Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). Blood samples were collected at admission to the ER before any therapeutic intervention. Results:We included 100 patients (mean age 58.6

Biomarkers 40

Biomarkers Strokes Stroke Hemorrhage 40

Physiologically Speaking

JULY 24, 2024

His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. We talk about why the ketogenic diet is helpful for people with diabetes and then dive into the details of each study to explore how 10 years on the diet affected cardiovascular health risk factors and clinical biomarkers.

Diabetes 115

Diabetes Diet Physiology Biomarkers 115

HeartRhythm

APRIL 30, 2024

An aggregate weighted scoring system utilising fully-customised 3D models of patient hearts, combining functional and structural biomarkers, allows the opportunity for the enhanced assessment of patient risk and outcomes.

Sudden Cardiac Death 40

Sudden Cardiac Death Biomarkers Heart Disease Defibrillator 40

Stroke Journal

JANUARY 30, 2025

Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition. Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40