Heart BMJ

AUGUST 26, 2024

1 Supporting evidence of elevated inflammatory biomarkers and findings of pericardial inflammation on cardiac magnetic resonance or CT also play critical roles in its evaluation.

Pericarditis 105

Pericarditis Chest Pain Outcomes Biomarkers 105

Circulation: Heart Failure

MARCH 14, 2025

The genotype-phenotype interdependence causes unpredictable phenotypic penetrance that results in a variety of signs and symptoms and patient outcomes. Cardiovascular biomarkers and multimodality imaging may identify initial amyloidogenic organ involvement.

Genetic predisposition 71

Genetic predisposition Heart Failure Biomarkers Circulation 71

HCPLive

JANUARY 23, 2024

Wesley Mizutani, MD, discusses California's SB 496 legislation, which addresses the crucial role of biomarkers in guiding optimal drug selection to improve overall healthcare outcomes.

Biomarkers 59

Biomarkers Outcomes 59

Journal of Clinical Investigation - Cardiology

APRIL 1, 2024

There is unmet need for additional biomarkers to better select patients with non–small cell lung cancer (NSCLC) that are likely to benefit from immunotherapy in order to improve patient outcomes, reduce patient toxicity, and relieve the growing burden of healthcare costs.

Biomarkers 58

Biomarkers Cancer Outcomes 58

Frontiers in Cardiovascular Medicine

FEBRUARY 11, 2024

In this review, we summarize the diagnostic and prognostic tools for ICI-myocarditis, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, with emphasis on circulating biomarkers.

Biomarkers 64

Biomarkers Circulation Cancer Outcomes 64

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

Furthermore, we highlight how recent trends in prescription of GLP-1 receptor antagonists are serving to motivate patients to manage biomarkers related to T2D and obesity, which are also relevant in cardiovascular disease.

Cardiovascular Disease 52

Cardiovascular Disease Biomarkers Obesity Outcomes 52

HCPLive

AUGUST 16, 2024

Strnad explains the need for noninvasive biomarkers in AATD liver disease and early research about circulating Z-polymer’s potential association with clinically relevant adverse outcomes.

Biomarkers 52

Biomarkers Circulation Research Outcomes 52

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2024

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies.

Myocardial Infarction 52

Myocardial Infarction Physiology Biomarkers Innovation 52

Heart BMJ

MAY 10, 2024

A timely diagnosis and initiation of evidence-based treatments are key to prevent hospitalisation and improve outcomes in this population. Biomarkers have dramatically impacted the way patients with HF are evaluated and managed. The most studied biomarkers in HF are natriuretic peptides (NPs).

Biomarkers 52

Biomarkers Heart Failure Physiology Article 52

HeartRhythm

AUGUST 25, 2024

Neurofilament light chain (NFL) protein is a biomarker for neurodegenerative diseases. Atrial fibrillation (AF) is an age-related disorder closely linked to autonomic nervous system dysfunction.

Atrial Fibrillation 81

Atrial Fibrillation Biomarkers Ablation Outcomes 81

Stroke Journal

JANUARY 30, 2025

Introduction:Net water uptake (NWU) is a novel biomarker which measures edema and tissue injury from the degree of hypoattenuation on non-contrast CT and may serve as a precision tool for predicting outcomes after acute ischemic stroke (AIS). When controlling for confounders, NWU was non-inferior to ASPECTS.

Biomarkers 40

Biomarkers Outcomes Strokes Stroke 40

Journal of Cardiothoracic Surgery

FEBRUARY 4, 2025

The aim of this review is to summarize the literature concerning the prognostic ability of various preoperative biomarkers for patien. Aortic dissections and repairs are associated with high rates of mortality.

Biomarkers 40

Biomarkers Aortic Outcomes 40

NEJM Journal Watch - Cardiology

AUGUST 29, 2024

Yes, but proving unequivocally that these measurements — added to clinical assessment — improve outcomes is still a work in progress.

Biomarkers 68

Biomarkers Outcomes 68

Stroke Journal

FEBRUARY 1, 2024

Results:Univariate analysis unveiled candidate molecules predictive of outcomes. Multivariate combinatory linear discriminant analysis (LDA) demonstrated significant prognostic potential for favorable outcomes.

Biomarkers 40

Biomarkers Outcomes Aneurysm Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Background:Endovascular thrombectomy (EVT) dramatically improves clinical outcomes, but the final infarct volume (FIV) on MRI only accounts for a minority of the treatment effect. Good outcome was defined as 2 on the 90-day modified Rankin Scale. The mean age was 69 13 years, 41% were female, and 62% achieved a good outcome.

Biomarkers 40

Biomarkers Outcomes Circulation Strokes 40

Stroke Journal

JANUARY 30, 2025

4.94), but not with 90-day mRS or mortality.Conclusion:Serum creatinine-based biomarkers of renal dysfunction were associated with faster progressor phenotype of ACLVO stroke, higher mRS, and mortality at 90 days. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).

Biomarkers 40

Biomarkers Circulation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Introduction:Endovascular thrombectomy (EVT) dramatically improves clinical outcomes, but the reduction in final infarct volume only accounts for a minority of the treatment effect. Good functional outcome was defined as a 90-day modified Rankin Scale score 2. MRI was performed 1248 hours post-EVT. vs 30.3%, p<0.0001).Table

Biomarkers 40

Biomarkers Outcomes Strokes Stroke 40

Open Heart

OCTOBER 31, 2024

Results Baseline characteristics revealed significant differences between NUA and HUA groups, with the latter exhibiting a higher prevalence of males, chronic kidney disease (CKD) and elevated levels of various biomarkers. Our findings suggest that monitoring and managing SUA could be crucial in improving patient with HF outcomes.

Heart Failure 52

Heart Failure Kidney Disease Blood Pressure Biomarkers 52

Journal of the American Heart Association

FEBRUARY 13, 2024

BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Journal of the American Heart Association, Ahead of Print.

Biomarkers 72

Biomarkers Strokes Stroke Myocardial Infarction 72

Stroke Journal

JANUARY 30, 2025

Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical. The study found that GFAP levels were significantly higher in HS patients, particularly among those with fatal outcomes. Survivors had GFAP levels of 1.35

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

DAIC

APRIL 9, 2024

The PROACT study reported no impact on cardiotoxicity biomarkers or secondary endpoints related to heart function among patients who took high doses of enalapril, an ACE inhibitor, along with high doses of anthracyclines. The PROACT study will continue to track outcomes in the study participants for at least 12 months.

ACE Inhibitor 105

ACE Inhibitor Cancer Biomarkers Heart Failure 105

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

These outcomes are driven by inflammatory processes. Given the pivotal role of inflammatory mediators in the pathogenesis of aortic calcification, inflammation has attracted interest as a peripheral biomarker for early mortality prediction in patients with aortic calcification.

Aortic 52

Aortic Atherosclerosis Laboratory Biomarkers 52

HCPLive

JULY 30, 2024

Greater circulating Z-polymer levels were associated with an increased risk of adverse clinical outcomes in adults with AATD and the PiZZ genotype.

Circulation 52

Circulation Biomarkers Outcomes 52

Stroke Journal

JANUARY 30, 2025

Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. These biomarkers could facilitate timely interventions, potentially improving outcomes for stroke patients.

Biomarkers 40

Biomarkers Physiology Hemorrhage Strokes 40

Stroke Journal

JANUARY 30, 2025

Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). Blood samples were collected at admission to the ER before any therapeutic intervention. Results:We included 100 patients (mean age 58.6

Biomarkers 40

Biomarkers Strokes Stroke Hemorrhage 40

Physiologically Speaking

JULY 24, 2024

His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. We talk about why the ketogenic diet is helpful for people with diabetes and then dive into the details of each study to explore how 10 years on the diet affected cardiovascular health risk factors and clinical biomarkers.

Diabetes 115

Diabetes Diet Physiology Biomarkers 115

Stroke Journal

JANUARY 30, 2025

Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition. Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025.

Biomarkers 40

Biomarkers Strokes Stroke Outcomes 40

HCPLive

SEPTEMBER 13, 2024

Multiple biomarkers and clinical background factors were linked to improved clinical outcomes after dupilumab therapy for AD.

Biomarkers 59

Biomarkers Outcomes 59

DAIC

FEBRUARY 3, 2025

This clearance comes in advance of disease-modifying therapies on the horizon expected to help clinicians use this biomarker to guide patients to improved cardiovascular health, saidBrad Moore, president and CEO at Roche Diagnostics North America. The development of the Tina-quant Lipoprotein (a) Gen.2

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Stroke Journal

JANUARY 30, 2025

Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. However, not all patients with successful reperfusion experience good functional outcomes.

Biomarkers 40

Biomarkers Strokes Stroke Ischemia 40

Stroke Journal

JANUARY 30, 2025

Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Finally, as neutrophil counts (and the ratio of neutrophils to lymphocytes) are reported to be a biomarker for DCI, we assessed these measures too. Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. nucleosome.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Cardiovascular Diabetology

OCTOBER 13, 2024

Triglyceride (TG) and its related metabolic indices are recognized as important biomarker gauging cardiovascular diseases. This study aimed to explore the association between multiple TG-derived metabolic indi.

Biomarkers 52

Biomarkers Heart Disease Cardiovascular Disease Diabetes 52

European Journal of Heart Failure

NOVEMBER 29, 2023

ABSTRACT Aims Heart failure outcomes remain poor despite advances in therapy. The European Society of Cardiology Heart Failure III Registry (ESC HF III Registry) aims to characterize HF clinical features and outcomes and to assess implementation of guideline-recommended therapy in Europe and other ESC affiliated countries.

Heart Failure 75

Heart Failure Preserved Ejection Fraction Quality of Life Biomarkers 75

Circulation: Heart Failure

JANUARY 16, 2025

However, no biomarker reflecting RVD is available for routine clinical use.METHODS:Proteomic analysis of myocardium from the left ventricle and right ventricle (RV) of patients with heart failure with reduced ejection fraction with (n=10) and without RVD (n=10) who underwent heart transplantation was performed.

Biomarkers 40

Biomarkers Heart Failure Heart Transplant Transplant 40

Stroke Journal

DECEMBER 14, 2023

BACKGROUND:Iron status has been associated with functional outcomes after ischemic stroke (IS). We also took genetic variants related to 4 biomarkers of iron status from combining gene-wide association study results of Iceland, the United Kingdom, and Denmark to perform a replicate Mendelian randomization analysis. 1.50];P=2.27×10−9;

Outcomes 40

Outcomes Strokes Stroke Biomarkers 40

Stroke Journal

MARCH 28, 2025

This investigation describes the prevalence, risk factors, and outcomes associated with FVH in pediatric arterial ischemic stroke (AIS).METHODS:Retrospective Wilcoxon rank-sum test evaluated the association of FVH score with the presence of LVO and poor outcome. P<0.0001) and Pediatric Stroke Outcome Measure at 1 year (rs=0.32;P=0.012).

Pediatrics 40

Pediatrics Biomarkers Strokes Stroke 40

Cardiovascular Diabetology

APRIL 28, 2024

Glycemic control, as measured by glycosylated hemoglobin (HbA1c), is an important biomarker to evaluate diabetes severity and is believed to be associated with heart failure development. Type 2 diabetes mellit.

Heart Failure 52

Heart Failure Diabetes Biomarkers Outcomes 52