Open Heart

JANUARY 29, 2024

Objectives This study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers. Methods Eligible studies were identified using several article databases.

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Myocardial Infarction STEMI Article Biomarkers 52

Open Heart

JUNE 24, 2022

Objective Short-term ambient fine particulate matter (PM 2.5 ) is associated with adverse cardiovascular events including myocardial infarction (MI). on cardiac troponin I, a cardiomyocyte specific biomarker of cellular damage. However, few studies have examined associations between PM 2.5

Myocardial Infarction 52

Myocardial Infarction Biomarkers Cardiovascular Disease 52

The American Journal of Cardiology

DECEMBER 13, 2023

Immune-inflammatory biomarkers have been shown to be correlated with impaired coronary flow (ICF) in ST-segment elevation myocardial infarction.

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Journal of the American Heart Association

FEBRUARY 13, 2024

In patients with AIS with rising cTn, acute ischemic myocardial infarction was present in 54%, compared with 33% in those with falling cTn (P<0.01). Of 3789 patients with AIS screened, 300 were included. Seventy‐two had a rising pattern, 66 falling, and 162 nondynamic.

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Biomarkers Stroke Strokes Myocardial Infarction 72

Journal of the American Heart Association

JANUARY 31, 2024

BackgroundMicrovascular obstruction (MVO) and intramyocardial hemorrhage (IMH) are well‐established imaging biomarkers of failed myocardial tissue reperfusion in patients with ST‐segment elevation–myocardial infarction treated with percutaneous coronary intervention.

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Myocardial Infarction Thrombolysis Biomarkers Hemorrhage 40

Circulation

NOVEMBER 11, 2024

These challenges highlight the need for new therapies that are both safe and effective in targeting the structural remodeling pivotal to disease progression post-myocardial infarction (MI). Current treatments are limited by side effects, poor patient compliance, and the necessity for gradual drug titration.

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Myocardial Infarction Heart Failure Cardiac Function Biomarkers 40

Coronary Artery Disease Journal

NOVEMBER 26, 2023

Aim Acute injury and subsequent remodelling responses to ST-segment elevation myocardial infarction (STEMI) are major determinants of clinical outcome. Current imaging and plasma biomarkers provide delayed readouts of myocardial injury and recovery.

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Myocardial Infarction STEMI Biomarkers Outcomes 40

Dr. Smith's ECG Blog

SEPTEMBER 26, 2023

See these 2 articles Association between pre-hospital chest pain severity and myocardial injury in ST elevation myocardial infarction: A post-hoc analysis of the AVOID study Author links open overlay panel [link] 1 Background We sought to determine if an association exists between prehospital chest pain severity and markers of myocardial injury.

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Chest Pain STEMI Myocardial Infarction Electrocardiogram 118

Frontiers in Cardiovascular Medicine

AUGUST 7, 2024

This article evaluates the utility of S100A8/A9 protein as a biomarker and therapeutic target for diagnosing cardiovascular diseases, considering its structural features, fundamental biological properties, and its multifaceted influence on cardiovascular conditions including atherosclerosis, myocardial infarction, myocardial ischemia/reperfusion injury, (..)

Cardiovascular Disease 52

Cardiovascular Disease Myocardial Infarction Atherosclerosis Biomarkers 52

HeartRhythm

AUGUST 22, 2024

Neural and electrical remodeling are well documented in the acute setting of myocardial infarction (MI). Sympathetic nerve sprouting in the infarct border zone increases transmural dispersion of repolarization, promoting arrhythmias.

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STEMI Biomarkers Myocardial Infarction Document 40

Heart BMJ

MAY 23, 2024

High-sensitivity cardiac troponin (hs-cTn) T and I assays are the preferred cardiac biomarkers to detect myocardial injury, support the diagnosis of acute myocardial infarction (MI) and facilitate rapid risk stratification of patients with suspected acute coronary syndrome (ACS).

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Myocardial Infarction Biomarkers 52

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Analysis of inflammatory biomarkers and coronary CTA was also performed at baseline and 4 weeks after treatment. Among those, 58% had diabetes, 50% had myocardial infarction, and 91% were in use of statin and aspirin. Clinical and laboratory safety evaluations were made at baseline and every 3 weeks until the end of the study.

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Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

CardiacWire

APRIL 24, 2024

Over 750k people are diagnosed with myocardial infarction in the United States every year, and a new JAMA paper suggests that far more of those patients are incorrectly diagnosed than many might expect.

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Myocardial Infarction Chest Pain Biomarkers Ischemia 59

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Multiple metabolites of KP have been observed to exhibit elevated concentrations in plasma across various cardiovascular diseases, such as atherosclerosis, hypertension, and acute myocardial infarction. Multiple studies have indicated that kynurenine (KYN) may serve as a potential biomarker for several adverse cardiovascular events.

Cardiovascular Disease 52

Cardiovascular Disease Atherosclerosis Myocardial Infarction Physiology 52

Open Heart

MARCH 19, 2024

Differentiation requires coronary angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS and ACS to determine if differences in biomarker profile can aid diagnosis. to 0.80; p<0.00001) and 5.8

Myocardial Infarction 52

Myocardial Infarction Biomarkers Heart Failure 52

The British Journal of Cardiology

JUNE 11, 2024

Additionally, 2D transthoracic echocardiography (TTE), and myocardial injury serum biomarkers assays (creatine phosphokinase-MB [CPK-MB] and cardiac troponins [cTn]) were measured once. The most common symptom was left hemithorax and interscapular pain (317 patients, 46%).

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Dr. Smith's ECG Blog

APRIL 18, 2024

1] European guidelines add "regardless of biomarkers". Immediate and early percutaneous coronary intervention in very high-risk and high-risk non-ST segment elevation myocardial infarction patients. But only 6.4% of such ‘high risk Non-STEMI’ patients get angiography within 2 hours.[2] Clin Cardiol 2022 4. McLaren and Smith.

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STEMI Chest Pain Myocardial Infarction Blog 120

Circulation

NOVEMBER 11, 2024

Background:Little is known about the clinical relevance of interleukin (IL)-6 and the severity of patients with acute ST-elevation myocardial infarction (STEMI). Blood samples for biomarker analyses, including IL-6, were collected.Results:There were 64 consecutive STEMI patients. There was 75% of males.

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STEMI Myocardial Infarction Tricuspid Biomarkers 40

Circulation

FEBRUARY 23, 2024

BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Circulation, Ahead of Print.

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Myocardial Infarction Cardiac Function Biomarkers Heart Failure 45

Frontiers in Cardiovascular Medicine

JANUARY 6, 2025

Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the related critical genes as biomarkers for ischemic heart disease.MethodsThe single nuclei RNA sequencing (snRNA-seq) and bulk RNA sequencing datasets used in this study were obtained from the Gene Expression Omnibus (GEO).

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Myocardial Infarction Heart Failure Biomarkers Heart Disease 40

Dr. Smith's ECG Blog

JUNE 18, 2013

Studies show that 30% of NonSTEMI have an occluded infarct artery at the time of angiography done 24 hours after presentation. These patients have worse outcomes: higher mortality, more CHF, higher biomarkers, and worse ejection fractions than the NonSTEMI patients with open arteries. This is because of subtle ECG findings.

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STEMI Chest Pain Myocardial Infarction Webinar 52

Dr. Smith's ECG Blog

JANUARY 3, 2022

So even without the diagnostic ECGs, they had clinical evidence of refractory ischemia with biomarker (troponin) confirmation. Prospective validation of current quantitative electrocardiographic criteria for ST-elevation myocardial infarction. V5-V6) of any amplitude, is specific for Occlusion Myocardial Infarction (vs.

STEMI 52

STEMI Myocardial Infarction Chest Pain Ischemia 52

Dr. Smith's ECG Blog

DECEMBER 14, 2016

Acute myocardial injury: Is it myocardial infarction, or perhaps myocarditis? less than 2 h from hospital admission, analogous to STEMI management) invasive strategy with intent to perform revascularization is recommended, irrespective of ECG or biomarker findings. Is it acute or chronic? Is it STEMI or NonSTEMI?

Chest Pain 52

Chest Pain STEMI Aortic Myocardial Infarction 52

Dr. Smith's ECG Blog

DECEMBER 11, 2023

Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). The ESC states that patients with suspected ACS should go to the cath lab in ＜2 hours "regardless of ECG or biomarker evidence of MI!!" link] Opiates are associated with worse outcomes in Myocardial Infarction.

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Frontiers in Cardiovascular Medicine

FEBRUARY 24, 2025

IntroductionAcute coronary syndrome refers to a group of diseases characterized by sudden, decreased blood supply to the heart muscle that results in cell death, also known as acute myocardial infarction. The majority of patients (67.9%) have been diagnosed with ST- Elevated Myocardial Infarction and were classified as Killip class I.

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Hospital Myocardial Infarction Chest Pain Electrocardiogram 98

Frontiers in Cardiovascular Medicine

NOVEMBER 17, 2024

Coronary heart disease (CHD), with common complications including myocardial infarction, arrhythmia, heart failure, is one of the leading causes of global death. Both elevated lactate levels and decreased albumin levels may reflect the body's stress response and inflammatory reaction.

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ICU Heart Disease Myocardial Infarction Biomarkers 59

Open Heart

OCTOBER 23, 2024

Background Since 2000, the definition of myocardial infarction (MI) has evolved with reliance on cardiac troponin (cTn) tests. Linked biomarker results were classified as ‘diagnostic’ for MI according to established criteria. Results There were 37 272 ACS admissions in 30 683 patients (64.2%

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Biomarkers Hospital STEMI Myocardial Infarction 52

Circulation

NOVEMBER 11, 2024

This study investigates the relationship between baseline 5-HTP levels and the incidence of major adverse cardiovascular events (MACE) in patients who have experienced ST-elevation myocardial infarction (STEMI).Objective:Our years, 53 women) followed for up to 15 years.

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Myocardial Infarction Coronary Artery Bypass Graft STEMI Angina 40

Dr. Smith's ECG Blog

AUGUST 9, 2024

Frick -- one wonders about the diagnosis of unstable angina in a patient with significantly elevated biomarkers which would certainly have been rising on repeat measurement.) AIVR is not always the result of significant pathology, but is classically associated with the reperfusion phase of acute myocardial infarction.

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Chest Pain Arrhythmia Myocardial Infarction STEMI 106

Dr. Smith's ECG Blog

MAY 8, 2023

Diagnosis of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block using the ST Elevation to S-Wave Ratio in a Modified Sgarbossa Rule. Electrocardiographic Diagnosis of Acute Coronary Occlusion Myocardial Infarction in Ventricular Paced Rhythm Using the Modified Sgarbossa Criteria.

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Chest Pain Myocardial Infarction STEMI Pacemaker 52

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

age, sex, ACS presentation, history of hypertension, smoking, diabetes, prior myocardial infarction (MI), heart failure, prior ischemic stroke, and cancer], laboratory tests [i.e., positive cardiac biomarker, hemoglobin, platelet count, white blood cell (WBC) count], and treatment [i.e.,

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Stents Stent Thrombosis Myocardial Infarction 64

Open Heart

DECEMBER 7, 2023

Data were mapped based on the population assessed, cardiovascular outcomes examined, inclusion of objective measures of cardiac dysfunction such as biomarkers or cardiovascular imaging, or whether cardiovascular symptoms or patient-reported functional outcomes measures were recorded.

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Article Myocardial Infarction Cardiovascular Imaging Biomarkers 52

DAIC

JANUARY 23, 2024

3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4 Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. 4 In the U.S. 12 Importantly, colchicine, 0.5 N Engl J Med.

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Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Circulation

NOVEMBER 14, 2024

BACKGROUND:Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. CONCLUSIONS:Measurement of targeted protein biomarkers produced superior prediction of aggregated and disaggregated cardiovascular events. Circulation, Ahead of Print.

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Cardiovascular Disease Dementia Biomarkers Myocardial Infarction 40

European Journal of Heart Failure

NOVEMBER 26, 2024

( A ) The cumulative incidence rate for cardiovascular death (CVD) was higher in the same control patients when analysed using baseline inflammatory plasma biomarkers high-sensitivity C-reactive protein (hsCRP) 2mg/L ( left panel ) and interleukin (IL)-6 3.4pg/ml ( right panel ).

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Heart Failure Myocardial Infarction Risk Factors Stroke 40

Circulation

NOVEMBER 11, 2024

Furthermore, the LDL-to-HDL ratio has been connected to long-term clinical outcomes like death and recurrent myocardial infarction, which may be associated with HT risk.Conclusions:In individuals with ischemic stroke, NLR and LDL-to-HDL ratios are potential HT indicators.

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Hemorrhage Stroke Strokes Myocardial Infarction 40

Circulation

OCTOBER 22, 2023

The key secondary endpoint was the composite of death, myocardial infarction (MI), or stroke. of patients were female and 55% presented with biomarker positive ACS. years, 23.2% Rates of all-cause death, MI, or stroke were not significantly different between groups (2.4% vs. 2.7%; HR 0.91, 95% CI 0.68-1.21; 1.21; P = 0.515).

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Myocardial Infarction Biomarkers Academic Stroke 40