Frontiers in Cardiovascular Medicine

FEBRUARY 7, 2024

Introduction Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. Objective The precise mechanisms driving the progression of hypertension remain unknown.

Hypertension 64

Hypertension Blood Pressure Biomarkers Heart Disease 64

Heart BMJ

AUGUST 26, 2024

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complex pulmonary vascular disorder that involves major vessel and microvascular disease components. 1 2 Secondary microvasculopathy of CTEPH forms the pathophysiological basis for pulmonary hypertension-targeted medical therapies given for CTEPH.

Pulmonary 52

Pulmonary Hypertension Biomarkers Angioplasty 52

Medical Xpress - Cardiology

JULY 2, 2024

For example, blood pressure changes during exercise (EBP) can reveal a latent tendency toward future development of hypertension. At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk.

Hypertension 52

Hypertension Blood Pressure Exercise Physiology 52

Hypertension Journal

NOVEMBER 29, 2023

Hypertension, Ahead of Print. Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations.

Dementia 64

Dementia Hypertension Pharmacology Biomarkers 64

Circulation

NOVEMBER 11, 2024

Background:Acquired mitochondrial dysfunction is one of the characteristics of pulmonary arterial hypertension (PAH). Exploring potential biomarkers from mitochondrial perspective may be effective in the diagnosis and treatment of PAH. Molecular docking and drug prediction showed estradiol is a potential targeted drug for ARMCX3.

Biomarkers 40

Biomarkers Pulmonary Hypertension Circulation 40

Cardiovascular Diabetology

DECEMBER 12, 2023

This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing.

Hypertension 52

Hypertension Stroke Strokes Biomarkers 52

Frontiers in Cardiovascular Medicine

APRIL 30, 2024

This study aims to identify risk factors for new-onset HDP and to develop a prediction model for assessing the risk of new-onset hypertension during pregnancy.MethodsWe included 446 pregnant women without baseline hypertension from Liyang People's Hospital at the first inspection, and they were followed up until delivery.

Risk Factors 52

Risk Factors Hypertension BMI Blood Pressure 52

Journal of the American Heart Association

DECEMBER 24, 2024

BackgroundChronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral smallvessel disease. Journal of the American Heart Association, Ahead of Print. Microvessels were isolated for gene expression profiling and invitro pericyte expansion.

Hypertension 45

Hypertension Biomarkers Circulation 45

Frontiers in Cardiovascular Medicine

JULY 24, 2024

BackgroundThe relationship between human immunodeficiency virus (HIV) infection and pulmonary arterial hypertension (PAH) has garnered significant scrutiny. Individuals with HIV infection have a higher risk of developing PAH. However, the specific mechanism of HIV-associated PAH remains unclear.

Pulmonary 52

Pulmonary Hypertension Biomarkers Download 52

Circulation

MARCH 9, 2025

Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults with few cardiovascular risk factors. Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025.

Kidney Disease 83

Kidney Disease Biomarkers Heart Failure Risk Factors 83

Circulation: Heart Failure

NOVEMBER 11, 2024

Background:Distinguishing hypertrophic cardiomyopathy (HCM) from other cardiomyopathies with left ventricular hypertrophy (LVH), such as hypertensive LVH, transthyretin amyloid cardiomyopathy (ATTR-CM), and aortic stenosis (AS), is sometimes challenging. Of those, 5 proteins were selected as candidate proteins.

Cardiomyopathy 40

Cardiomyopathy Biomarkers Circulation Hypertension 40

Circulation

JANUARY 12, 2024

BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). Circulation, Ahead of Print.

Pulmonary 45

Pulmonary Hypertension Biomarkers Circulation 45

Hypertension Journal

MARCH 6, 2024

Hypertension, Ahead of Print. Generalized estimating equations were used to estimate the associations of 233 plasma proteins with hypertension and systolic blood pressure (SBP). Validation in the KORA-Age1/Age2 study replicated 7 proteins associated with hypertension and 23 associated with SBP. years of follow-up.

Blood Pressure 45

Blood Pressure Hypertension Biomarkers Research 45

Stroke Journal

JANUARY 30, 2025

Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical. Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025.

Hemorrhage 40

Hemorrhage Biomarkers Stroke Strokes 40

Circulation: Heart Failure

MARCH 5, 2025

BACKGROUND:Exercise-induced hypertension (EIH) is common in adults with coarctation of the aorta (COA), but there are limited data about hemodynamics and outcomes in such patients. Circulation: Heart Failure, Ahead of Print.

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Exercise Hypertension Outcomes Biomarkers 40

Hypertension Journal

SEPTEMBER 6, 2023

Hypertension, Volume 80, Issue 12 , Page 2547-2555, December 1, 2023. BPV was evaluated by the SD, coefficient of variation, and average real variability of the patients’ 24-hour ambulatory and home systolic BP values.RESULTS:During the median 7.0-year year follow-up, 109 cardiovascular events occurred.

Blood Pressure 40

Blood Pressure Biomarkers Hypertension Outpatient 40

Hypertension Journal

JANUARY 2, 2024

Hypertension, Ahead of Print. Hypertension is the primary modifiable risk factor for cardiovascular, renal, and cerebrovascular diseases and is considered the main contributing factor to morbidity and mortality worldwide.

Hypertension 40

Hypertension Blood Pressure Cerebrovascular Disease Risk Factors 40

Circulation

DECEMBER 22, 2023

There was no strong evidence of an interaction between urinary sodium and a standard genome-wide polygenic score of BP.CONCLUSIONS:The data suggest that genetic risk in sodium and potassium pathways could be used in a precision medicine model to direct interventions more specifically in the management of hypertension.

Hypertension 45

Hypertension Blood Pressure Biomarkers Risk Factors 45

Frontiers in Cardiovascular Medicine

JULY 17, 2024

The triglyceride–glucose (TyG) index, proven to be a crucial insulin resistance biomarker (better than the Homeostasis Model Assessment for Insulin Resistance), is simple and non-invasive.

Heart Failure 64

Heart Failure Atherosclerosis Obesity Biomarkers 64

Stroke Journal

FEBRUARY 1, 2024

were women, 87% had hypertension, 48.1% It also identifies a novel biomarker for ischemic strokes from atherosclerosis. The relationship between stroke etiology (TOAST criteria) and IL-2Rα was assessed using ANOVA and then adjusted for co-morbidities using multilinear regression models.Results:The mean age of patients was 63.4

Biomarkers 40

Biomarkers Stroke Strokes Atherosclerosis 40

Stroke Journal

JANUARY 30, 2025

years, 54% were women, 87% had hypertension, 44% had diabetes mellitus, and 54% had hyperlipidemia. Only two out of the 48 cytokines demonstrated differences with thrombectomy. CCL4 levels were significantly higher in patients that underwent thrombectomy, 55.717.4 pg/ml vs. 39.520.6

Biomarkers 40

Biomarkers Stroke Strokes Ischemia 40

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2025

Abnormal stress biomarkers [regional wall motion abnormalities (RWMAs), ST-segment depression, induced angina, peak systolic blood pressure, force-based contractile reserve (CR), heart rate reserve (HRR), and low exercise capacity] were used for phenotyping.

Chest Pain 52

Chest Pain Exercise Angina Coronary Artery Disease 52

Cardiometabolic Health Congress

JULY 25, 2024

Innovations in Cardiorenal Metabolic Medicine The event will focus on the whole spectrum of cardiorenal metabolic disease, including obesity, diabetes, lipids, hypertension, and cardiorenal disease. Michos, MD, MHS, FACC, FAHA, FASE, FASPC ; famed hypertension expert Keith C. Morris, MD as featured speakers; CMHC co-chairs Anne L.

Education 100

Education Innovation Risk Factors Obesity 100

CardiacWire

JANUARY 24, 2024

CardioSignal has already developed digital biomarkers for AFib and heart failure, while more solutions could be on the way for aortic stenosis, coronary artery disease, and pulmonary artery hypertension.

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AFIB Coronary Artery Disease Biomarkers Heart Failure 75

Journal of the American Heart Association

NOVEMBER 28, 2023

BackgroundPulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis. Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023.

Congenital Heart Disease 40

Congenital Heart Disease Congenital Pulmonary Heart Disease 40

Hypertension Journal

DECEMBER 11, 2024

Hypertension, Ahead of Print. BACKGROUND:Renin-independent aldosterone production in normotensive people increases risk for developing hypertension. These findings provide mechanistic explanations to implicate PA in the pathogenesis of a substantial proportion of hypertension.

Blood Pressure 40

Blood Pressure Biomarkers Hypertension 40

Heart BMJ

APRIL 15, 2024

Participants underwent clinical cardiovascular evaluation, ECG, cardiac biomarker evaluation and CMR. 33% of participants had a new finding of hypertension. All participants had normal LVEF prior to, and on completion of, treatment. Left ventricular systolic dysfunction (LVSD) was defined as LVEF <50%. years (range 5.9–10.8

Cancer 52

Cancer Risk Factors Biomarkers Cholesterol 52

Hypertension Journal

JANUARY 22, 2025

Hypertension, Ahead of Print. BACKGROUND:Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Sphingosine-1-phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development.

Biomarkers 40

Biomarkers Hypertension 40

Stroke Journal

JANUARY 30, 2025

The most common comorbidities were hyperlipidemia (93.3%) and hypertension (80%). Furthermore, these patients could benefit from early surgical intervention if these biomarkers were to be detected. There were 73.3% male patients. of patients had symptomatic disease. Eleven plaques were vulnerable in preoperative MRI with VWI.

Plaque 40

Plaque Biomarkers Risk Factors Stroke 40

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Multiple metabolites of KP have been observed to exhibit elevated concentrations in plasma across various cardiovascular diseases, such as atherosclerosis, hypertension, and acute myocardial infarction. Multiple studies have indicated that kynurenine (KYN) may serve as a potential biomarker for several adverse cardiovascular events.

Cardiovascular Disease 52

Cardiovascular Disease Atherosclerosis Myocardial Infarction Physiology 52

Open Heart

JULY 17, 2023

Arterial hypertension (HR 2.27; 95% CI 1.00 Arterial hypertension (HR 2.27; 95% CI 1.00 Kaplan-Maier estimators of the combined end point were 31% in patients with arterial hypertension, 56% in patients with severe valvular heart disease and 77% with both risk factors (HR 12.4, 95% CI 3.8

COVID-19 52

COVID-19 Outcomes Cardiovascular Interventions Risk Factors 52

Heart BMJ

FEBRUARY 23, 2024

We aim to assess differences in the biomarkers among the phenotypes of HFpEF and investigate its multifactorial pathophysiology. Biomarker characteristics in each phenotype were evaluated. Conclusions Distinctive characteristics of biomarkers in HFpEF phenotypes would indicate differential underlying mechanisms to be elucidated.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Hypertension 40

Stroke Journal

JANUARY 30, 2025

Patients with increasing CT-CSVD scores were older (p&lt;0.001), more likely to have hypertension (p&lt;0.001), diabetes (p&lt;0.001), coronary artery disease (p=0.044), and a higher baseline systolic blood pressure (p=0.037). 1.02; score 2: OR 0.46, 95%CI 0.26-0.83; 0.83; score 3: OR 0.16, 95%CI 0.03-0.76, 1.95, p = 0.019).Conclusion:This

Thrombolysis 40

Thrombolysis Outcomes Biomarkers Stroke 40

Hypertension Journal

DECEMBER 3, 2024

Hypertension, Ahead of Print. BACKGROUND:Circulating proteins in blood are involved in various physiological processes, but their contributions to blood pressure regulation remain partially understood.

Blood Pressure 40

Blood Pressure Circulation Hypertension Physiology 40

Hypertension Journal

NOVEMBER 17, 2023

Hypertension, Ahead of Print. BACKGROUND:Arterial stiffness, as measured by arterial pulse wave velocity (PWV), is an established biomarker for cardiovascular risk and target-organ damage in individuals with hypertension.

Hypertension 40

Hypertension Biomarkers Technology Research 40

Frontiers in Cardiovascular Medicine

FEBRUARY 13, 2024

By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g.,

Risk Factors 64

Risk Factors Laboratory Coronary Artery Disease Cerebrovascular Disease 64

DAIC

FEBRUARY 1, 2024

million, or 47% of adults are estimated to have hypertension.** percent of adults have high LDL-C (>/_ 130 mg/dL).** - The age-adjusted death rate attributable to CVD is 224.4 per 1,000* - 122.4 People with diabetes are twice as likely to have heart disease or a stroke than people without diabetes. -

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Stroke Strokes 104