Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe routinely used computed tomography (CT)‐based workup in the setting of acute ischemic stroke (AIS) includes non‐contrast brain CT, CT angiography (CTA), and CT perfusion.

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Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP12-ATP12, February 1, 2024. Results are a proof of concept that blood tests could replace more complex and costly imaging biomarkers in monitoring CA hemorrhage. Relative change in Phenylacetylglutamine and LPE.18.0+Piperine

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines. Of 25 enrolled patients, mean age was 65.8 (SD,

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Stroke Journal

MARCH 6, 2024

Stroke, Ahead of Print. BACKGROUND:The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025. A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A47-A47, February 1, 2025. Introduction:The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke is decisive for prehospital triage and initiation of targeted therapies. Blood samples were collected in the prehospital phase.

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Circulation

NOVEMBER 11, 2024

Background:Following an ischemic stroke, a serious complication known as hemorrhagic transformation (HT) might jeopardize patient outcomes. Following an ischemic stroke, an increased incidence of HT, especially parenchymal hematoma (PH), has been associated with greater NLR.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP44-ATP44, February 1, 2025. It is closely linked to Alzheimer's disease (AD) and predisposes elderly patients to intracerebral hemorrhage and cognitive impairment. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP226-AWP226, February 1, 2025. Objective:Hematoma expansion (HE) predicts disability and death after intracerebral hemorrhage (ICH). Specific biomarkers of platelet activity would improve our understanding of HE and could point towards targeted treatments.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP169-AWP169, February 1, 2024. We aimed to determine whether TEG R-time is useful in detecting the impact of PCC administration on anticoagulation activity in patients with anti-factor Xa-associated intracranial hemorrhage (ICH). TEG-R time may be a useful biomarker in DOAC reversal with PCC.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024. Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms.

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Biomarkers Outcomes Aneurysm Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2024. Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality. Malnutrition is common in stroke patients and leads to worse outcomes. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP310-ATP310, February 1, 2025. Introduction:Intracerebral Hemorrhage (ICH) is associated with a high case fatality and survivors of ICH are at increased risk for ICH recurrence. Roughly 20-30% of patients with ICH take a statin at the time of ICH onset.

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Hemorrhage Cholesterol Article Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A151-A151, February 1, 2024. Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage. Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP224-AWP224, February 1, 2025. Background:The astroglial protein GFAP (glial fibrillary acidic protein) is a promising biomarker candidate for prehospital differentiation between intracerebral hemorrhage (ICH) and ischemic stroke.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP4-ATMP4, February 1, 2025. Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP320-ATP320, February 1, 2025. The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear. The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear. <0.1).

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,

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Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP377-ATP377, February 1, 2025. Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A130-A130, February 1, 2024.

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Biomarkers Strokes Stroke Physiology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A57-A57, February 1, 2024. Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP343-ATP343, February 1, 2025. Background:Subarachnoid Hemorrhage (SAH) accounts for 2-7% of strokes and has high mortality and morbidity. The identified genes and networks may guide the search for potential biomarkers of outcome and novel treatment targets.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP232-AWP232, February 1, 2025. Background:Intracerebral hemorrhage (ICH) is a critical neurological condition with high rates of mortality and morbidity. However, fully adopting this biomarker for mortality outcome prediction requires further analysis of heterogeneity sources.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2025. Background:The Medical Research Council (MRC) scale is used to assess the impact of stroke on muscle strength. Shoulder abduction and finger extension, collectively (SAFE), have been suggested to have prognostic value for stroke outcomes (e.g.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP338-AWP338, February 1, 2025. Introduction:Extracranial carotid artery pathology accounts for 15-20% of ischemic strokes. From those, intraplaque hemorrhage was the most common feature (81.1%).Proteomic The most common comorbidities were hyperlipidemia (93.3%) and hypertension (80%).

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Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionLoss of autoregulation after endovascular therapy (EVT) for large‐artery acute ischemic stroke (AIS) is well documented. [1] Further studies are required to clarify the utility of this biomarker in guiding post‐EVT care.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2025. Introduction:Glial fibrillary acidic protein (GFAP), highly brain-specific, is emerging as an attractive blood biomarker in acute stroke. from onset, and 28% were wake-up strokes. 24h), and ASPECTS score (8-10 vs. <8).Results:Among

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP319-ATP319, February 1, 2024. Background:Hypothalamic injury after subarachnoid hemorrhage (SAH) is known to be associated with short- and long-term prognosis.

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Hemorrhage Physiology Biomarkers Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP209-ATP209, February 1, 2025. This workflow, which involves downloading imaging data from a clinical trials electronic data capture (EDC) system, performing biomarker analyses, and then re-entering data into the EDC, can be cumbersome when performed manually.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Introduction:ACTIMIS (NCT03803007) was a randomized phase 1b/2a clinical trial evaluating glenzocimab, a monoclonal antibody fragment targeting platelet receptor glycoprotein VI in patients with acute ischemic stroke treated by thrombolysis.

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Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIntracranial atherosclerosis‐related large vessel occlusion (ICAS‐LVO) is a common cause of failed mechanical thrombectomy (MT) in acute ischemic stroke (AIS) [1].

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP75-ATMP75, February 1, 2024. Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP64-AWMP64, February 1, 2024. These patients had an increased hemorrhagic transformation rate of 68% with only 1 in 3 patients having favorable clinical outcome. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury.

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Journal of the American Heart Association

DECEMBER 14, 2024

We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.Methods and ResultsWe enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer'sdisease as controls.

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Stroke: Vascular and Interventional Neurology

JANUARY 25, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. Fear of hemorrhagic complications (74%) was the most compelling reason not to perform RS±angioplasty. The preferred medication during acute RS was intravenous antiplatelet therapy (65%), and after acute RS, it was dual oral antiplatelet therapy (65%).

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