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Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical. Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025.
Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. These biomarkers could facilitate timely interventions, potentially improving outcomes for stroke patients.
BACKGROUND:Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations.
While researchers in the Alzheimer disease field have been working for years to establish and test blood-based biomarkers for Alzheimer disease diagnosis, prognosis, clinical therapy discovery, and early detection, blood-based biomarkers for VCID are in their infancy and also face challenges.
Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Finally, as neutrophil counts (and the ratio of neutrophils to lymphocytes) are reported to be a biomarker for DCI, we assessed these measures too. Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. nucleosome.
Background:Increase in mean lesional iron content (≥6%) measurement by QSM and vascular permeability (≥ 40%) assessed by DCEQP MRI have been associated with new bleeding in cavernous angiomas (CA), and are used as monitoring biomarkers in clinical trial of pharmacotherapy in CAs with symptomatic hemorrhage (SH).
BACKGROUND:The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. Stroke, Ahead of Print.
A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.
We aimed to determine whether TEG R-time is useful in detecting the impact of PCC administration on anticoagulation activity in patients with anti-factor Xa-associated intracranial hemorrhage (ICH). TEG-R time may be a useful biomarker in DOAC reversal with PCC. Adults with ICH taking apixaban or rivaroxaban were included.
It is closely linked to Alzheimer's disease (AD) and predisposes elderly patients to intracerebral hemorrhage and cognitive impairment. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression.
Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To
Objective:Hematoma expansion (HE) predicts disability and death after intracerebral hemorrhage (ICH). Specific biomarkers of platelet activity would improve our understanding of HE and could point towards targeted treatments. Platelet activity is essential for coagulation, and the use of anti-platelet medication (e.g.,
Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). Blood samples were collected at admission to the ER before any therapeutic intervention. fold change and unadjusted p-value <0.05
Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage. Future biomarker studies are needed to better understand this relationship. 7.34) and lobar (OR 3.15, 95% CI 1.67-5.94) 5.94) groups.
Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications. Results:Overall, the median age was 52.5 years [IQR:45-63] and 76% were female.
Introduction:Intracerebral Hemorrhage (ICH) is associated with a high case fatality and survivors of ICH are at increased risk for ICH recurrence. Following the search, articles citing a correlation between statin use and risk of intracerebral hemorrhage were included. The search was conducted by two authors (PM and CO).
Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH. Thus, we sought to investigate various biomarkers of platelets to identify which factors are predictive of patients at-risk for DCI.
Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage. GFAP values over 1000 pg/ml indicated a primary cerebral cause of coma with 100% certainty (hereof, 86% had intracranial hemorrhage).Conclusion:Increased
Background:The astroglial protein GFAP (glial fibrillary acidic protein) is a promising biomarker candidate for prehospital differentiation between intracerebral hemorrhage (ICH) and ischemic stroke. Stroke, Volume 56, Issue Suppl_1 , Page AWP224-AWP224, February 1, 2025. All blood samples were collected in the prehospital phase.
Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage. Timely and accurate risk stratification of IAs is paramount.Objective:Aneurysm wall enhancement (AWE) is a potential imaging biomarker for risk stratification.
Background:Intracerebral hemorrhage (ICH) is a critical neurological condition with high rates of mortality and morbidity. Conclusion:Spot sign visualized in conventional vascular imaging is a highly specific radiological biomarker for predicting mortality and poor functional outcomes in patients with ICH.
Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines. Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Of 25 enrolled patients, mean age was 65.8 (SD,
Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024.
Background:Subarachnoid Hemorrhage (SAH) accounts for 2-7% of strokes and has high mortality and morbidity. The identified genes and networks may guide the search for potential biomarkers of outcome and novel treatment targets. Stroke, Volume 56, Issue Suppl_1 , Page ATP343-ATP343, February 1, 2025.
Introduction:The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke is decisive for prehospital triage and initiation of targeted therapies. Glial fibrillary acidic protein (GFAP) is a highly promising blood biomarker indicating ICH.
Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies. Glial fibrillary acidic protein (GFAP) is a highly promising blood biomarker indicating acute ICH.
Background:Hypothalamic injury after subarachnoid hemorrhage (SAH) is known to be associated with short- and long-term prognosis. Recently, a novel hypothalamic protein, Sushi repeat-containing protein X-linked 2 (SRPX2), was reported as a potential biomarker for hypothalamic damage after traumatic brain injury.
Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.
Objective:To investigate the anatomical and physiological impact of intracerebral hemorrhage (ICH) on the mechanical CST distortion measured using serial MRI and its relation to functional recovery.Introduction:ICH causes CST (motor pathway for arm movement) deformation/displacement leading to disruption of brain-arm neuronal communication.
This workflow, which involves downloading imaging data from a clinical trials electronic data capture (EDC) system, performing biomarker analyses, and then re-entering data into the EDC, can be cumbersome when performed manually. Cloud computing completed the same tasks in an average of 8 minutes and 13 seconds.
Associations between clinical/magnetic resonance imaging features and CSF biomarker concentrations were investigated with univariate and multivariate models.ResultsWe identified 31 patients aged 69.68.4 CSF tau concentrations are linked to cognitive complaints, likely representing comorbid Alzheimer disease pathology.
From those, intraplaque hemorrhage was the most common feature (81.1%).Proteomic Furthermore, these patients could benefit from early surgical intervention if these biomarkers were to be detected. The most common comorbidities were hyperlipidemia (93.3%) and hypertension (80%). of patients had symptomatic disease.
Further subgroup analysis revealed significant differences between ischemic stroke and hemorrhagic stroke subgroups (P=0.03).Conclusions:These Moreover, variations in KYN exhibit significant differences among different stroke types, with more pronounced changes observed in hemorrhagic stroke.
Fear of hemorrhagic complications (70%) was the most compelling reason not to perform RS +/‐ angioplasty. There is no equipoise regarding the optimal treatment strategy, and the fear of hemorrhagic complications associated with antithrombotic medications contributes to the variation in practice.
Primary analysis demonstrated a reduction in intracranial hemorrhage occurrence stroke-related mortality. In this sub-analysis, volumetric imaging biomarkers were used to assess efficacy of glenzocimab.Methods:In the phase 2a study, patients were randomized (1:1) with 1000mg glenzocimab or placebo.
Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline. The cellular architecture in the lesions and their genetic alterations have not been elucidated, limiting biomarker development and therapeutic targeting.
We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.Methods and ResultsWe enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer'sdisease as controls.
These patients had an increased hemorrhagic transformation rate of 68% with only 1 in 3 patients having favorable clinical outcome. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury.
Fear of hemorrhagic complications (74%) was the most compelling reason not to perform RS±angioplasty. The preferred medication during acute RS was intravenous antiplatelet therapy (65%), and after acute RS, it was dual oral antiplatelet therapy (65%).
BackgroundMicrovascular obstruction (MVO) and intramyocardial hemorrhage (IMH) are well‐established imaging biomarkers of failed myocardial tissue reperfusion in patients with ST‐segment elevation–myocardial infarction treated with percutaneous coronary intervention. Journal of the American Heart Association, Ahead of Print.
5) Myocardial contusion (edema and hemorrhage in the myocardium) which may result in dysrhythmias, blocks (especially RBBB as here), and poor cardiac contractility, including wall motion abnormalities. Localized bleeding from contusion could cause hemopericardium even without rupture.
Males=147; Right Hemisphere=131; Ischemic=199, Hemorrhagic=27). The integrity of the corticospinal tract has frequently been suggested as a biomarker of stroke recovery. Only voxels lesioned in >10% of participants were tested.Results:We recruited 226 stroke participants at 2 weeks post-stroke (mean age=62.6;
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