Stroke Journal

MARCH 6, 2024

BACKGROUND:The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. Stroke, Ahead of Print.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.

Biomarkers 40

Biomarkers Aneurysm Cardiomyopathy Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

We aimed to determine whether TEG R-time is useful in detecting the impact of PCC administration on anticoagulation activity in patients with anti-factor Xa-associated intracranial hemorrhage (ICH). TEG-R time may be a useful biomarker in DOAC reversal with PCC. Adults with ICH taking apixaban or rivaroxaban were included.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

It is closely linked to Alzheimer's disease (AD) and predisposes elderly patients to intracerebral hemorrhage and cognitive impairment. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Objective:Hematoma expansion (HE) predicts disability and death after intracerebral hemorrhage (ICH). Specific biomarkers of platelet activity would improve our understanding of HE and could point towards targeted treatments. Platelet activity is essential for coagulation, and the use of anti-platelet medication (e.g.,

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). Blood samples were collected at admission to the ER before any therapeutic intervention. fold change and unadjusted p-value <0.05

Biomarkers 40

Biomarkers Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms. Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024.

Biomarkers 40

Biomarkers Outcomes Aneurysm Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage. Future biomarker studies are needed to better understand this relationship. 7.34) and lobar (OR 3.15, 95% CI 1.67-5.94) 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Stroke Journal

JANUARY 30, 2025

Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications. Results:Overall, the median age was 52.5 years [IQR:45-63] and 76% were female.

Aneurysm 40

Aneurysm Hemorrhage Biomarkers Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:Intracerebral Hemorrhage (ICH) is associated with a high case fatality and survivors of ICH are at increased risk for ICH recurrence. Following the search, articles citing a correlation between statin use and risk of intracerebral hemorrhage were included. The search was conducted by two authors (PM and CO).

Hemorrhage 40

Hemorrhage Cholesterol Article Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH. Thus, we sought to investigate various biomarkers of platelets to identify which factors are predictive of patients at-risk for DCI.

Ischemia 40

Ischemia Hemorrhage Biomarkers Aneurysm 40

Stroke Journal

FEBRUARY 1, 2024

Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage. GFAP values over 1000 pg/ml indicated a primary cerebral cause of coma with 100% certainty (hereof, 86% had intracranial hemorrhage).Conclusion:Increased

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Background:The astroglial protein GFAP (glial fibrillary acidic protein) is a promising biomarker candidate for prehospital differentiation between intracerebral hemorrhage (ICH) and ischemic stroke. Stroke, Volume 56, Issue Suppl_1 , Page AWP224-AWP224, February 1, 2025. All blood samples were collected in the prehospital phase.

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage. Timely and accurate risk stratification of IAs is paramount.Objective:Aneurysm wall enhancement (AWE) is a potential imaging biomarker for risk stratification.

Aneurysm 40

Aneurysm Biomarkers Hemorrhage Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:Intracerebral hemorrhage (ICH) is a critical neurological condition with high rates of mortality and morbidity. Conclusion:Spot sign visualized in conventional vascular imaging is a highly specific radiological biomarker for predicting mortality and poor functional outcomes in patients with ICH.

Hemorrhage 40

Hemorrhage Outcomes Biomarkers Strokes 40

Stroke Journal

JANUARY 30, 2025

Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines. Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Of 25 enrolled patients, mean age was 65.8 (SD,

Exercise 40

Exercise Hemorrhage Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024.

Hemorrhage 40

Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Background:Subarachnoid Hemorrhage (SAH) accounts for 2-7% of strokes and has high mortality and morbidity. The identified genes and networks may guide the search for potential biomarkers of outcome and novel treatment targets. Stroke, Volume 56, Issue Suppl_1 , Page ATP343-ATP343, February 1, 2025.

Hemorrhage 40

Hemorrhage Outcomes Biomarkers Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke is decisive for prehospital triage and initiation of targeted therapies. Glial fibrillary acidic protein (GFAP) is a highly promising blood biomarker indicating ICH.

Hemorrhage 40

Hemorrhage Strokes Stroke Blood Pressure 40

Circulation

NOVEMBER 11, 2024

Background:Following an ischemic stroke, a serious complication known as hemorrhagic transformation (HT) might jeopardize patient outcomes. Circulation, Volume 150, Issue Suppl_1 , Page A4148181-A4148181, November 12, 2024.

Hemorrhage 40

Hemorrhage Strokes Stroke Myocardial Infarction 40

Stroke Journal

FEBRUARY 1, 2024

Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies. Glial fibrillary acidic protein (GFAP) is a highly promising blood biomarker indicating acute ICH.

Hemorrhage 40

Hemorrhage Biomarkers Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Background:Hypothalamic injury after subarachnoid hemorrhage (SAH) is known to be associated with short- and long-term prognosis. Recently, a novel hypothalamic protein, Sushi repeat-containing protein X-linked 2 (SRPX2), was reported as a potential biomarker for hypothalamic damage after traumatic brain injury.

Hemorrhage 40

Hemorrhage Physiology Biomarkers Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Objective:To investigate the anatomical and physiological impact of intracerebral hemorrhage (ICH) on the mechanical CST distortion measured using serial MRI and its relation to functional recovery.Introduction:ICH causes CST (motor pathway for arm movement) deformation/displacement leading to disruption of brain-arm neuronal communication.

Biomarkers 40

Biomarkers Strokes Stroke Physiology 40

Stroke Journal

JANUARY 30, 2025

This workflow, which involves downloading imaging data from a clinical trials electronic data capture (EDC) system, performing biomarker analyses, and then re-entering data into the EDC, can be cumbersome when performed manually. Cloud computing completed the same tasks in an average of 8 minutes and 13 seconds.

Download 40

Download Biomarkers Hemorrhage Research 40

Journal of the American Heart Association

MARCH 3, 2025

Associations between clinical/magnetic resonance imaging features and CSF biomarker concentrations were investigated with univariate and multivariate models.ResultsWe identified 31 patients aged 69.68.4 CSF tau concentrations are linked to cognitive complaints, likely representing comorbid Alzheimer disease pathology.

Biomarkers 40

Biomarkers Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

From those, intraplaque hemorrhage was the most common feature (81.1%).Proteomic Furthermore, these patients could benefit from early surgical intervention if these biomarkers were to be detected. The most common comorbidities were hyperlipidemia (93.3%) and hypertension (80%). of patients had symptomatic disease.

Plaque 40

Plaque Biomarkers Risk Factors Strokes 40

Stroke Journal

JANUARY 30, 2025

Further subgroup analysis revealed significant differences between ischemic stroke and hemorrhagic stroke subgroups (P=0.03).Conclusions:These Moreover, variations in KYN exhibit significant differences among different stroke types, with more pronounced changes observed in hemorrhagic stroke.

Strokes 40

Strokes Stroke Biomarkers Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Fear of hemorrhagic complications (70%) was the most compelling reason not to perform RS +/‐ angioplasty. There is no equipoise regarding the optimal treatment strategy, and the fear of hemorrhagic complications associated with antithrombotic medications contributes to the variation in practice.

Atherosclerosis 40

Atherosclerosis Angioplasty Stent Stents 40

Stroke Journal

FEBRUARY 1, 2024

Primary analysis demonstrated a reduction in intracranial hemorrhage occurrence stroke-related mortality. In this sub-analysis, volumetric imaging biomarkers were used to assess efficacy of glenzocimab.Methods:In the phase 2a study, patients were randomized (1:1) with 1000mg glenzocimab or placebo.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline. The cellular architecture in the lesions and their genetic alterations have not been elucidated, limiting biomarker development and therapeutic targeting.

Biomarkers 40

Biomarkers Hemorrhage Strokes Stroke 40

Journal of the American Heart Association

DECEMBER 14, 2024

We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.Methods and ResultsWe enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer'sdisease as controls.

Dementia 40

Dementia Biomarkers Hemorrhage Hypertension 40

Stroke Journal

FEBRUARY 1, 2024

These patients had an increased hemorrhagic transformation rate of 68% with only 1 in 3 patients having favorable clinical outcome. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Outcomes 40

Stroke: Vascular and Interventional Neurology

JANUARY 25, 2024

Fear of hemorrhagic complications (74%) was the most compelling reason not to perform RS±angioplasty. The preferred medication during acute RS was intravenous antiplatelet therapy (65%), and after acute RS, it was dual oral antiplatelet therapy (65%).

Atherosclerosis 40

Atherosclerosis Angioplasty Stenosis Stent 40

Journal of the American Heart Association

JANUARY 31, 2024

BackgroundMicrovascular obstruction (MVO) and intramyocardial hemorrhage (IMH) are well‐established imaging biomarkers of failed myocardial tissue reperfusion in patients with ST‐segment elevation–myocardial infarction treated with percutaneous coronary intervention. Journal of the American Heart Association, Ahead of Print.

Myocardial Infarction 40

Myocardial Infarction Thrombolysis Biomarkers Hemorrhage 40

Dr. Smith's ECG Blog

JULY 22, 2012

5) Myocardial contusion (edema and hemorrhage in the myocardium) which may result in dysrhythmias, blocks (especially RBBB as here), and poor cardiac contractility, including wall motion abnormalities. Localized bleeding from contusion could cause hemopericardium even without rupture.

Dysrhythmia 52

Dysrhythmia Biomarkers Echocardiogram Ultrasound 52