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Heart transplantation and biomarkers: a review about their usefulness in clinical practice

Frontiers in Cardiovascular Medicine

Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. These biomarkers are typically linked to complications from HTX.

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A gentler approach to monitor for heart transplant rejection

Frontiers in Cardiovascular Medicine

Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy.

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Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm

Frontiers in Cardiovascular Medicine

To improve our understanding of BAV pathogenesis, we characterized the cellular composition of BAV tissues and identified molecular changes in each cell population.MethodsTissue samples from two patients with BAV and two heart transplant donors were analyzed using single-cell RNA sequencing, assay for transposase-accessible chromatin using sequencing, (..)

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Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5

Circulation: Heart Failure

BACKGROUND:Right ventricular dysfunction (RVD) is common in patients with heart failure with reduced ejection fraction, and it is associated with poor prognosis.

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Abstract 4113494: Gut Microbiota Modulation by Immunosuppression and Cardiac Cell Therapy in a Nonhuman Primate Ischemia/Reperfusion Model of Cardiac Regeneration

Circulation

End-stage ischemic heart disease necessitates heart transplantation, and emerging cell therapy presents a promising solution to address donor scarcity. Disruption of gut microbiota significantly influences various diseases and treatments, including transplantation.

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Championing Change: Celebrating Cardiometabolic Health Congress (CMHC) Women Faculty

Cardiometabolic Health Congress

Her research focuses on women’s cardiovascular health and cardio-obstetrics, cardiovascular risk prediction using coronary artery calcium scores and biomarkers, lipids, and cardiometabolic diseases.

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Published Research

Society of Thoracic Surgeons - Research

Hunter Mehaffey Distressed communities are associated with worse outcomes after coronary artery bypass surgery The Journal of Thoracic and Cardiovascular Surgery August 2019 Meghana Helder Regional and Temporal Trends in the Outcomes of Repairs for Acute Type A Aortic Dissections The Annals of Thoracic Surgery August 2019 Derrick Tam Surgical valve (..)