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More than half of the patients presented with heartfailure (n=2,234, 55.4%), followed by acute myocardialinfarction (n=1,368, 34.0%), coronary artery disease (n=674, 16.7%), and acute coronary syndrome (n=164, 4.1%). Poor ventricular function (26.16.8
a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced success from a collaborative Phase II trial of ProtheraCytes for the treatment of acute myocardialinfarction (AMI) led by CellProthera , as well as plans to continue the relationship into Phase III.
BackgroundTrimethylamine N-oxide (TMAO) has been widely explored and considered as a biomarker for adverse cardiovascular events. Therefore, this meta-analysis aimed to estimate association between TMAO levels and the prognosis of patients with myocardialinfarction (MI).MethodsWe were systematically addressed.
IntroductionHypoxic liver injury (HLI) and Killip classification are poor prognostic factors in patients with ST-segment elevation myocardialinfarction (STEMI). Left ventricular ejection fraction (LVEF) was below 45% in symptomatic, overt heartfailure patients (Killip class II, III, and IV).
These challenges highlight the need for new therapies that are both safe and effective in targeting the structural remodeling pivotal to disease progression post-myocardialinfarction (MI). Current treatments are limited by side effects, poor patient compliance, and the necessity for gradual drug titration.
This article evaluates the utility of S100A8/A9 protein as a biomarker and therapeutic target for diagnosing cardiovascular diseases, considering its structural features, fundamental biological properties, and its multifaceted influence on cardiovascular conditions including atherosclerosis, myocardialinfarction, myocardial ischemia/reperfusion injury, (..)
Objective Takotsubo syndrome (TTS) is an acute heartfailure syndrome which resembles acute coronary syndrome (ACS) at presentation. Differentiation requires coronary angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. to 0.80; p<0.00001) and 5.8
Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the related critical genes as biomarkers for ischemic heart disease.MethodsThe single nuclei RNA sequencing (snRNA-seq) and bulk RNA sequencing datasets used in this study were obtained from the Gene Expression Omnibus (GEO).
BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardialinfarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Circulation, Ahead of Print.
The elevated troponin is diagnostic of myocardial injury. There was a normal creatinine and no evidence of heartfailure and no other reason for chronic injury, so it must be acute. Acute myocardial injury: Is it myocardialinfarction, or perhaps myocarditis? Is it acute or chronic? Is it STEMI or NonSTEMI?
Coronary heart disease (CHD), with common complications including myocardialinfarction, arrhythmia, heartfailure, is one of the leading causes of global death. Both elevated lactate levels and decreased albumin levels may reflect the body's stress response and inflammatory reaction.
This study investigates the relationship between baseline 5-HTP levels and the incidence of major adverse cardiovascular events (MACE) in patients who have experienced ST-elevation myocardialinfarction (STEMI).Objective:Our years, 53 women) followed for up to 15 years.
( A ) The cumulative incidence rate for cardiovascular death (CVD) was higher in the same control patients when analysed using baseline inflammatory plasma biomarkers high-sensitivity C-reactive protein (hsCRP) 2mg/L ( left panel ) and interleukin (IL)-6 3.4pg/ml ( right panel ). TTFE, time-to-first event.
Data were mapped based on the population assessed, cardiovascular outcomes examined, inclusion of objective measures of cardiac dysfunction such as biomarkers or cardiovascular imaging, or whether cardiovascular symptoms or patient-reported functional outcomes measures were recorded.
BACKGROUND:Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. CONCLUSIONS:Measurement of targeted protein biomarkers produced superior prediction of aggregated and disaggregated cardiovascular events. Circulation, Ahead of Print.
CI, confidence interval; EDMi, end-diastolic mass index; HF, heartfailure; HR, hazard ratio; LVEF, left ventricular ejection fraction. Aim Left ventricular (LV) global longitudinal strain (GLS) may detect subtle abnormalities in myocardial contractility among individuals with normal LV ejection fraction (LVEF).
There was no enrichment of rare variants in DCM-associated genes in patients with NI-LGE compared to patients without this imaging biomarker. Abstract Aims To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD).
(Public health messaging about COVID appears to have kept people away from hospitals, and autopsy series of deaths during the pandemic found that reduced access to health care systems (for conditions such as myocardialinfarction) was more far likely to be identified as a contributory factor to death than undiagnosed COVID-19).
Adult Cardiac Surgery Database Lead Author Title Publication Date Jacob Raphael Red Blood Cell Transfusion and Pulmonary Complications: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis The Annals of Thoracic Surgery January 2024 Joseph Sabik Multi-Arterial versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million (..)
Program Designations Access and Publications (A&P) 1 Participant User File (PUF) 2 Task Force on Funded Research (TFR) 3 Special Projects 4 Adult Cardiac Surgery Database Lead Author Title Publication Date William Keeling 2 National Trends in Emergency Coronary Artery Bypass Grafting European Journal of Cardiothoracic Surgery October 2023 Jake (..)
Objective To characterise cardiac remodelling, exercise capacity and fibroinflammatory biomarkers in patients with aortic stenosis (AS) with and without diabetes, and assess the impact of diabetes on outcomes. Secondary endpoint was all-cause death.
The left atrioventricular coupling index (LACI) has emerged as a novel and transformative biomarker in cardiovascular research, addressing long-standing limitations in traditional cardiac function assessments.
Emerging Risk Factors: Non-traditional factors such as the microbiome, pollution, and somatic mutations are increasingly linked to “SMuRFless” myocardialinfarction (MI) cases. Biomarker-Based HF Prediction: Combined biomarker and imaging assessments provide the highest accuracy in predicting heartfailure risk.
It could also, given a different clinical context be compatible with a subacute myocardialinfarction complicated by post infarct regional pericarditis. The only other processes identified that caused this type of postinfarction T wave evolution were cardiopulmonary resuscitation, reinfarction, and very small infarcts.
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