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Ten presentations will feature new data from the pivotal Phase III FINEARTS-HF cardiovascular (CV) outcomes trial, which investigated KERENDIA for treatingt adult patients with heartfailure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF). Additional ACC.25
Background Heartfailure (HF) is a leading cause of morbidity and mortality worldwide. Results Baseline characteristics revealed significant differences between NUA and HUA groups, with the latter exhibiting a higher prevalence of males, chronic kidneydisease (CKD) and elevated levels of various biomarkers.
Ten presentations will feature new data from the pivotal Phase III FINEARTS-HF cardiovascular (CV) outcomes trial, which investigated KERENDIA for treatingt adult patients with heartfailure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF). Additional ACC.25
Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidneydisease, or heartfailure, as well as among adults with few cardiovascular risk factors. Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025.
Journal of the American Heart Association, Ahead of Print. ABSTRACT: Albuminuria, an established biomarker of the progression of chronic kidneydisease, is also recognized as a biomarker for the risk of cardiovascular disease. However, screening for albuminuria is still low.
Abstract Background Extracellular matrix remodeling is one of the key pathways involved in heartfailure (HF) progression. A mixed model repeated measurements model (MMRM) was used to evaluate the effect of empagliflozin vs. placebo on the analysed biomarkers. SGLT2 inhibitors may have a role in attenuating myocardial fibrosis.
However, multi-parametric techniques and biomarkers which are available for investigating cardiovascular diseases and kidneydiseases may offer opportunities for the evaluation of CRS. Circulation, Volume 150, Issue Suppl_1 , Page A4147019-A4147019, November 12, 2024.
By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g.,
Abstract Aims Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative cardiomyopathy that commonly presents with concomitant chronic kidneydisease. Albuminuria is common in heartfailure and associated with worse outcomes, but its prevalence and relationship to outcome in ATTR-CA remains unclear.
Measuring eGFR and albuminuria is recommended for assessing kidneydisease in all hypertensive patients. Solomon, MD and Muthiah Vaduganathan, MD, MPH (USA) presented results showing that finerenone significantly reduced heartfailure hospitalizations and cardiovascular death in patients with HFmrEF and HFpEF.
Additionally, 10% of the global population suffers from chronic kidneydisease , with diabetes and hypertension as significant risk factors. Disparities in care are also concerning, with diagnosed cardiometabolic diseases varying up to twofold among different racial and ethnic groups. .” In the U.S.,
Background Acute kidney injury (AKI) in the context of acute decompensated heartfailure (ADHF) encompasses a broad spectrum of phenotypes with associated disparate outcomes. AKI was defined using KidneyDisease Improving Global Outcomes (KDIGO) AKI criteria.
Both reperfusion, as judged by the biomarker curve, and patency, as assessed by the angiogram, were correlated with the rapidity and depth of T wave inversion. Most of the time with acute MI little additional information is provided by physical examination ( with exception of those acute MI patients who present with heartfailure or shock ).
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