Dr. Paddy Barrett

APRIL 12, 2024

But for many people regular exercise at even moderate intensities will not be on the cards. Maybe you are one of the fortunate ones who loves to exercise at a high level and has managed to land in the top 2.5% Medicine & Science in Sports & Exercise 42(10):p 1819-1825, October 2010. That is something we can all aim for.

Quality of Life 124

Quality of Life Blood Pressure Exercise Chronic Disease 124

Stroke Journal

JANUARY 30, 2025

We assessed safety of moderate intensity exercise in the acute phase and its association with pro-inflammatory cytokines and BDNF expression.Methods:This was a prospective, single center, randomized, pilot of prescribed exercise for patients hospitalized with stroke.

Exercise 40

Exercise Hemorrhage Stroke Strokes 40

Physiologically Speaking

JANUARY 12, 2024

One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. Physical fitness was measured using VO2 peak obtained during a maximal exercise test (the gold standard way to measure this outcome). What can’t we infer from this study?

Physiology 124

Physiology BMI Exercise Diet 124

Circulation

JANUARY 22, 2025

In our study, NT-proBNP provided little value in those with AF and dyspnea because the presence of AF is by itself a robust biomarker of HFpEF. Use of separate rule-in and rule-out diagnostic thresholds stratified by BMI reduces miscategorization and can guide more appropriate use of exercise testing for possible HFpEF.

Preserved Ejection Fraction 55

Preserved Ejection Fraction Outpatient Heart Failure BMI 55

Journal of the American Heart Association

MARCH 7, 2025

Both drugs demonstrated substantial benefit in reducing left ventricular outflow tract obstruction (Valsalva left ventricular outflow tract gradients improved by 45 mm Hg or better), symptom burden (placebocorrected New York Heart Association class improvement 1 of at least 30%), and cardiac biomarkers (geometric mean ratio of 0.2

Cardiomyopathy 45

Cardiomyopathy Quality of Life Atrial Fibrillation Pharmacology 45

Cardiometabolic Health Congress

AUGUST 8, 2024

A meta-analysis published in the Journal of Consulting and Clinical Psychology found that motivational interviewing effectively promoted behavior change across various health domains, including diet and exercise. Key contributions: Advanced cardiac imaging (e.g.,

Education 59

Education Cardiovascular Disease Diabetes Kidney Disease 59

Physiologically Speaking

MARCH 13, 2024

Within exercise and sports science, no one measure has gotten more attention than VO2 max. VO2 max refers to your maximum rate of oxygen consumption, and it’s typically measured during a maximal exercise test to exhaustion (they’re not fun, trust me). The VO2 plateau indicating the achievement of VO2 max.

Exercise 52

Exercise Physiology Research Biomarkers 52

DAIC

APRIL 9, 2024

Decline in exercise ability is a hallmark of progression to overt heart failure. The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy. Patients had had Type 2 diabetes for an average of 14 years.

Heart Failure 52

Heart Failure Diabetes Cardiomyopathy Exercise 52

Journal of the American Heart Association

FEBRUARY 14, 2024

In addition, renal injury, oxidative stress, inflammation, and profibrotic biomarkers were evaluated to determine pathways associated with RDN. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF).We

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Blood Pressure Obesity 40

Circulation: Heart Failure

OCTOBER 23, 2023

BACKGROUND:Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive. Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Exercise 40

DAIC

OCTOBER 2, 2024

vs 24% showed enhanced exercise capacity and 84% vs 8% demonstrated a substantial response in cardiac biomarkers (for all p aficamten achieved one or more clinically relevant outcomes, 62% achieved at least three outcomes and 23% achieved all four outcomes.

Cardiomyopathy 40

Cardiomyopathy Sudden Cardiac Death Biomarkers Heart Failure 40

Physiologically Speaking

AUGUST 9, 2024

So rather than investigate how specific nutrients affect health biomarkers, there’s a growing interest in how restricting or supplying these nutrients might affect physical activity and energy expenditure, key factors in overall health. It’s also important to acknowledge that each of us respond to nutrients and food differently.

Physiology 69

Physiology Diet Cholesterol Obesity 69

Physiologically Speaking

MARCH 29, 2024

There’s a surge in research devoted to finding the best time to exercise. In a new study, evening exercise, but not morning exercise, reduced blood pressure, lowered sympathetic activity, and improved baroreflex sensitivity in a group of adults with treated hypertension. “When is the best time to exercise?

Blood Pressure 52

Blood Pressure Exercise Physiology Hypertension 52

Physiologically Speaking

MAY 17, 2024

You won’t find a more potent longevity drug than exercise. “To exercise, or not to exercise” is not the question. Rather, intense debate surrounds what the optimal dose of exercise is for longevity. Rather, intense debate surrounds what the optimal dose of exercise is for longevity.

Physiology 98

Physiology Exercise Biomarkers Cardiovascular Disease 98

Physiologically Speaking

DECEMBER 8, 2023

Exercise is the most potent longevity intervention we have at our disposal. To my knowledge, there’s not a study that doesn’t show that at least some exercise is better than none , and most even show that more exercise is better when it comes to improving healthspan and lifespan. Not completely.

Exercise 59

Exercise Physiology Research Biomarkers 59

Open Heart

AUGUST 16, 2023

Objective To characterise cardiac remodelling, exercise capacity and fibroinflammatory biomarkers in patients with aortic stenosis (AS) with and without diabetes, and assess the impact of diabetes on outcomes. Secondary endpoint was all-cause death. to 4.00; p=0.037).

Exercise 52

Exercise Diabetes Stenosis Aortic 52

DAIC

DECEMBER 18, 2024

The current version of the CardioFlux Score analyzes 14 unique biomarkers that quantify the heart muscle's electrical activity and then compares those results to a benchmark of healthy, symptom-free individuals.

Heart Disease 52

Heart Disease Technology Cardiac Function Biomarkers 52

Physiologically Speaking

APRIL 24, 2024

4 Many environmental and lifestyle factors can throw our circadian system out of whack, which is why being prudent about sleep, diet, and exercise are crucial. The most common stimulus is an increase in blood flow (due to exercise), which elevates the production of nitric oxide (NO) and leads to the dilation (widening) of the artery diameter.

Blood Pressure 52

Blood Pressure Blood Clot COVID-19 Cardiovascular Disease 52

Frontiers in Cardiovascular Medicine

MARCH 17, 2025

mL/kg/min; p=0.297], while exercise ventilatory efficiency (VE/VCO2 slope) improved [from 34.2 NYHA class improved (p=0.002), paralleled by a decrease of MECKI (Metabolic Exercise test data combined with Cardiac and Kidney Indexes) score, from 3.3% (1.98.0) At T2, mean LVEF increased (from 34.67.8 30.237.6); p=0.006]. to 14.61.7g/dL;

Exercise 40

Exercise Biomarkers Heart Failure Pulmonary 40

Heart BMJ

NOVEMBER 25, 2024

Background Participation in regular exercise activities is recommended for patients with chronic heart failure. However, less is known about the effect of exercise in patients with genetic dilated cardiomyopathy (DCM). Trial design Non-randomised clinical pre-post trial of exercise training. mL/kg / min (95% CI +0.9

Exercise 52

Exercise Cardiomyopathy Outpatient Biomarkers 52

Physiologically Speaking

DECEMBER 17, 2024

This has raised concerns that long-term, high-volume exercise might be detrimental to heart health. Notably, athletes engaging in very vigorous-intensity exercise are more likely to develop calcified plaques. Training load : Weekly exercise volume, measured as MET-hours/week, showed a positive trend.

Risk Factors 105

Risk Factors Genetic predisposition Plaque Exercise 105

Open Heart

NOVEMBER 27, 2024

Methods Patients with rate-controlled persistent AF and LVEF<50% undergoing catheter ablation (CA) were prospectively evaluated using echocardiography, cardio-pulmonary exercise testing and serum N-terminal pro b-type natriuretic peptide (NT-proBNP) at baseline and 6 months after CA.

Atrial Fibrillation 52

Atrial Fibrillation Cardiomyopathy Ablation Cardiac Function 52

Dr. Paddy Barrett

MARCH 14, 2025

The goal of exercising for longevity has two goals. 2 Powerpenia Should be Considered a Biomarker of Healthy Aging. 12 Powerpenia Should be Considered a Biomarker of Healthy Aging. The first is extending lifespan - how long you live. The second is improving healthspan - The quality of your life as you age. Am J Prev Med.

Dementia 111

Dementia Biomarkers Cancer Exercise 111