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Dallas-based UT Southwestern Medical Center researchers found a two-step screening protocol combining clinical risk assessment with biomarker testing that can identify which patients with Type 2 diabetes need medication to prevent heart failure.
Andrew is a research scientist at Sansum DiabetesResearch Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.
25 include Efficacy and safety of finerenone across the spectrum of kidney risk in heart failure with mildly reduced or preserved ejection fraction during the session;"Innovations and Insights in Heart Failure With Preserved Ejection Fraction: Emerging Therapies, Biomarkers and Mechanistic Studies." Additional ACC.25
Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension (PAH). In pioneering research led by Kevin J.
This results in severe chest pain or discomfort, with the subsequent release of cardiac biomarkers, and alterations in the electrocardiogram. Hypertension and diabetes were the two most common risk factors identified. It can cause diminished heart function and mortality if not treated properly with suitable measures.
Coronary heart disease is a major global health problem, especially among people with type 2 diabetes. Researchers have identified novel protein biomarkers that are associated with the development of CHD in people with and without diabetes.
Among middle-aged adults, individuals with type 2 diabetes (T2D) have a two to four times higher risk of developing CHD than people without T2D. The research team investigated the predictive performance of protein biomarkers on incident CHD in individuals with and without T2D.
A two-step screening protocol that combines clinical risk assessment with biomarker testing can more effectively identify which patients with type 2 diabetes need medication to prevent heart failure, according to a study led by UT Southwestern Medical Center researchers.
Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. Type 2 Diabetes When it comes to the increasing the risk of major chronic diseases such as cardiovascular disease, many cancers and dementia, type 2 diabetes plays a huge role.
Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D.
Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does no.
Systemic stress, inflammation, and hydroelectrolytic and acid‒base abnormalities observed during diabetic ketoacidosis (DKA) can cause changes in the heart and even induce cardiovascular damage. We aimed to ev.
The triglyceride-glucose index serves as a dependable biomarker for gauging insulin resistance linked to cardiovascular disease. Our study was designed to investigate how the trajectory of the triglyceride-glu.
Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia.
In addition, market research firms, like FACTMR referenced here, focused on the cardiology industry and regularly issue insightful reviews and forecasts worthy of note, portions of each shared here. People with diabetes are twice as likely to have heart disease or a stroke than people without diabetes. - In addition, 115.9
25 include Efficacy and safety of finerenone across the spectrum of kidney risk in heart failure with mildly reduced or preserved ejection fraction during the session;"Innovations and Insights in Heart Failure With Preserved Ejection Fraction: Emerging Therapies, Biomarkers and Mechanistic Studies." Additional ACC.25
Coronary artery disease (CAD) and diabetes mellitus (DM) can induce changes in myocardial structure and function, thereby increasing the risk of heart failure (HF). We aimed to identify the alterations in echo.
Type 2 Diabetes Mellitus (T2DM) presents a significant healthcare challenge, with considerable economic ramifications. While blood glucose management and long-term metabolic target setting for home care and ou.
Glycemic control, as measured by glycosylated hemoglobin (HbA1c), is an important biomarker to evaluate diabetes severity and is believed to be associated with heart failure development. Type 2 diabetes mellit.
Gestational diabetes mellitus (GDM) significantly impacts maternal and infant health both immediately and over the long term, yet effective early diagnostic biomarkers are currently lacking. Thus, it is essent.
Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal.
Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults with few cardiovascular risk factors. Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025.
The research was presented at the American College of Cardiology ’s Annual Scientific Session. The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy.
The new model uses a set of 10 factors including age, cigarette smoking status, diabetes status, and blood levels of several cardiac biomarkers, to gauge the risk of a new cardiovascular event, regardless of whether the patient has had one before. Parameters of the new model are available in the paper supplements.
Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. Aims Abnormalities in specific echocardiographic parameters and cardiac biomarkers have been reported among individuals with diabetes. The high-risk DbCM phenotype was identified based on the incidence of HF on follow-up.
Studies have demonstrated that coronary artery calcification on one hand and non-alcoholic fatty liver disease (NAFLD) on the other hand are strongly associated with cardiovascular events. However, it remains.
Triglyceride (TG) and its related metabolic indices are recognized as important biomarker gauging cardiovascular diseases. This study aimed to explore the association between multiple TG-derived metabolic indi.
The pericoronary fat attenuation index (FAI) has emerged as a novel and sensitive biomarker reflecting the degree of coronary artery inflammation. Semaglutide has been demonstrated to exert a cardiovascular pr.
Background:Peripheral artery disease (PAD) is associated with high morbidity and mortality and is closely related to diabetes mellitus (DM) and atherosclerosis. General population samples from the National Health Research Institutes were used as the control group to compare the methylation status.
I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. Pharmaceutical Research, Vol.
One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. Finally, having dyslipidemia (abnormal levels of blood lipids) and diabetes were associated with a higher age acceleration. A recent study provides us with some novel insight.
SGLT2-i, sodiumglucose cotransporter 2 inhibitor; T2D, type 2 diabetes. Sodiumglucose cotransporter 2 inhibitors, a class of anti-diabetic drugs, showed to improve cardiovascular functions although their mechanism of action has not yet been fully established.
MicroRNAs (miRs) have been associated with thrombosis and the blood clotting cascade and can provide additional insight about pathogenesis or biomarkers to help establish safe dietary intake guidelines. However, multiomics studies of both xylitol metabolites and these miRs in humans have not been done.
Keynote speaker and atherosclerosis expert Peter Libby, MD , captivated the audience with an update on his research into inflammation and atherosclerosis. Attendees dove into cutting-edge topics, including FDA updates, resistant hypertension, and cardiac biomarkers. “I I am very inspired and rejuvenated at the 19th Annual CMHC.
Participants with the worst GLS (Q4) were more likely male and of the Black race with a history of tobacco use and diabetes with lower LVEF, higher LV end-diastolic volume, and higher LV mass index. Cumulative incidence of MACE was higher among participants with worse (Q4 vs. Q1) GLS (20.4%
7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 N Engl J Med. 2019;381(26):2497-2505.
Patients with albuminuria had a more severe cardiac phenotype evidenced by higher serum cardiac biomarkers (median NT-proBNP: 4027ng/L [2173-6889] vs 1851ng/L [997-3209], P<0.001; median troponin-T: 69ng/L [46-101] vs 48ng/L [34-68], P<0.001) and worse echocardiographic indices of systolic (longitudinal strain: -10.0±3.6%
These differences remained significant even after adjusting for age, gender, body mass index, history of diabetes mellitus, arterial hypertension, and coronary artery disease. Our study showed SGLT2 gene and protein hyper-expression in patients with LF-LG AS, compared to controls and HG AS ( p < 0.05).
IntroductionThe COVID-19 pandemic, starting in 2020, raised concerns about potential long-term health impacts, including its effects on cardiovascular health and related biomarkers. The prevalence and treatment rates of diabetes, hypertension, and dyslipidemia remained consistent.
There is increased cognizance of gender inequality and the importance of inclusive and diverse approaches to medical research. Historically, women have been underrepresented in scientific fields, and this spills over into the research and study of women’s health.
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