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Medical Xpress - Cardiology
JANUARY 25, 2024
An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes.
Physiologically Speaking
JULY 24, 2024
Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.
115 
Becker's Hospital Review - Cardiology
JANUARY 3, 2024
Dallas-based UT Southwestern Medical Center researchers found a two-step screening protocol combining clinical risk assessment with biomarker testing that can identify which patients with Type 2 diabetes need medication to prevent heart failure.
110 
Cardiovascular Diabetology
MARCH 19, 2025
This study aims to identify early metabolomic biomarkers of gestational diabetes mellitus (GDM) and evaluate their association with hepatic steatosis.
52 
Science Daily - Heart Disease
MARCH 18, 2024
Coronary heart disease is a major global health problem, especially among people with type 2 diabetes. Researchers have identified novel protein biomarkers that are associated with the development of CHD in people with and without diabetes.
71 
HCPLive
JANUARY 29, 2024
A systematic review of over 400 studies in type 2 diabetes reveals 13 biomarkers, including NT-proBNP and troponin-t, with potential to significantly enhance cardiovascular disease risk prediction.
Medical Xpress - Cardiology
JANUARY 2, 2024
A two-step screening protocol that combines clinical risk assessment with biomarker testing can more effectively identify which patients with type 2 diabetes need medication to prevent heart failure, according to a study led by UT Southwestern Medical Center researchers.
Cardiovascular Diabetology
NOVEMBER 1, 2024
Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D.
Cardiovascular Diabetology
DECEMBER 17, 2024
Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does no.
59 
Cardiovascular Diabetology
OCTOBER 27, 2024
Systemic stress, inflammation, and hydroelectrolytic and acid‒base abnormalities observed during diabetic ketoacidosis (DKA) can cause changes in the heart and even induce cardiovascular damage. We aimed to ev.
52 
Cardiovascular Diabetology
JANUARY 19, 2024
Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia.
69 
Cardiovascular Diabetology
MARCH 20, 2025
The triglyceride-glucose index serves as a dependable biomarker for gauging insulin resistance linked to cardiovascular disease. Our study was designed to investigate how the trajectory of the triglyceride-glu.
Med Page Today
JUNE 23, 2024
(MedPage Today) -- ORLANDO -- An investigational triple-hormone receptor agonist improved metabolic profiles of people with obesity with or without type 2 diabetes, an exploratory biomarker analysis of a phase II trial found. After 36 weeks.
92 
Cardiovascular Diabetology
MARCH 7, 2025
Coronary artery disease (CAD) and diabetes mellitus (DM) can induce changes in myocardial structure and function, thereby increasing the risk of heart failure (HF). We aimed to identify the alterations in echo.
Cardiovascular Diabetology
MAY 2, 2024
Type 2 Diabetes Mellitus (T2DM) presents a significant healthcare challenge, with considerable economic ramifications. While blood glucose management and long-term metabolic target setting for home care and ou.
52 
HCPLive
APRIL 7, 2025
Used as a biomarker across many specialties, the platelet-to-neutrophil ratio may soon enter ophthalmology for diabetic macular edema prediction.
64 
Cardiovascular Diabetology
APRIL 28, 2024
Glycemic control, as measured by glycosylated hemoglobin (HbA1c), is an important biomarker to evaluate diabetes severity and is believed to be associated with heart failure development. Type 2 diabetes mellit.
Cardiovascular Diabetology
AUGUST 6, 2024
Gestational diabetes mellitus (GDM) significantly impacts maternal and infant health both immediately and over the long term, yet effective early diagnostic biomarkers are currently lacking. Thus, it is essent.
52 
Cardiovascular Diabetology
JANUARY 12, 2025
Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal.
52 
European Journal of Heart Failure
NOVEMBER 3, 2024
Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. Aims Abnormalities in specific echocardiographic parameters and cardiac biomarkers have been reported among individuals with diabetes. The high-risk DbCM phenotype was identified based on the incidence of HF on follow-up.
Circulation: Genomic and Precision Medicine
FEBRUARY 7, 2024
BACKGROUND:The circulating proteome may encode early pathways of diabetes susceptibility in young adults for surveillance and intervention. kg/m2), with validation against diabetes in >1800 individuals in the FHS (Framingham Heart Study) and WHI (Women’s Health Initiative).RESULTS:In
40 Circulation
MARCH 9, 2025
Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults with few cardiovascular risk factors. Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025.
DAIC
APRIL 9, 2024
The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy. Patients had had Type 2 diabetes for an average of 14 years. Decline in exercise ability is a hallmark of progression to overt heart failure.
Cardiovascular Diabetology
FEBRUARY 12, 2024
Studies have demonstrated that coronary artery calcification on one hand and non-alcoholic fatty liver disease (NAFLD) on the other hand are strongly associated with cardiovascular events. However, it remains.
69 
Cardiovascular Diabetology
OCTOBER 13, 2024
Triglyceride (TG) and its related metabolic indices are recognized as important biomarker gauging cardiovascular diseases. This study aimed to explore the association between multiple TG-derived metabolic indi.
52 
Stroke Journal
FEBRUARY 1, 2024
Diabetes doubles the risk of VCID. We showed that diabetic but not control rats develop a progressive cognitive decline in a microemboli (ME) model of VCID. Behavioral deficits observed in the untreated diabetic rats were not noted in the treated group. Some of the biomarkers were unchanged (Table).
40 
Circulation: Heart Failure
JANUARY 16, 2025
However, no biomarker reflecting RVD is available for routine clinical use.METHODS:Proteomic analysis of myocardium from the left ventricle and right ventricle (RV) of patients with heart failure with reduced ejection fraction with (n=10) and without RVD (n=10) who underwent heart transplantation was performed.
40 
Cardiovascular Diabetology
SEPTEMBER 27, 2024
The pericoronary fat attenuation index (FAI) has emerged as a novel and sensitive biomarker reflecting the degree of coronary artery inflammation. Semaglutide has been demonstrated to exert a cardiovascular pr.
52 
Stroke Journal
FEBRUARY 1, 2024
had diabetes mellitus, and 53.7% It also identifies a novel biomarker for ischemic strokes from atherosclerosis. The relationship between stroke etiology (TOAST criteria) and IL-2Rα was assessed using ANOVA and then adjusted for co-morbidities using multilinear regression models.Results:The mean age of patients was 63.4 p<0.01).Conclusions:Our
40 
Stroke Journal
JANUARY 30, 2025
years, 54% were women, 87% had hypertension, 44% had diabetes mellitus, and 54% had hyperlipidemia. Only two out of the 48 cytokines demonstrated differences with thrombectomy. CCL4 levels were significantly higher in patients that underwent thrombectomy, 55.717.4 pg/ml vs. 39.520.6
40 
Circulation
NOVEMBER 11, 2024
Background:Peripheral artery disease (PAD) is associated with high morbidity and mortality and is closely related to diabetes mellitus (DM) and atherosclerosis. These findings suggest that VTRNA2-1 promoter methylation status could serve as a valuable biomarker for predicting prognosis and guiding treatment strategies in PAD.
Cardiometabolic Health Congress
JULY 25, 2024
Practical, Future-Focused Education Cardiorenal and metabolic diseases, fueled by poor lifestyle choices and health conditions, lead to type 2 diabetes, cardiovascular disease, and chronic kidney disease. The robust conference agenda begins with FDA updates and advancements in cardiorenal metabolic care.
100 
Heart BMJ
SEPTEMBER 25, 2024
Background Integration of large proteomics and genetic data in population-based studies can provide insights into discovery of novel biomarkers and potential therapeutic targets for cardiometabolic diseases (CMD). There were 245 potentially causal protein biomarkers identified in MR pooled results, involving 23 pleiotropic proteins.
52 
Frontiers in Cardiovascular Medicine
FEBRUARY 20, 2024
Analysis of inflammatory biomarkers and coronary CTA was also performed at baseline and 4 weeks after treatment. Among those, 58% had diabetes, 50% had myocardial infarction, and 91% were in use of statin and aspirin. Clinical and laboratory safety evaluations were made at baseline and every 3 weeks until the end of the study.
Heart BMJ
APRIL 15, 2024
Participants underwent clinical cardiovascular evaluation, ECG, cardiac biomarker evaluation and CMR. mmol/L and 5% had a new diagnosis of diabetes. All participants had normal LVEF prior to, and on completion of, treatment. Left ventricular systolic dysfunction (LVSD) was defined as LVEF <50%. years (range 5.9–10.8
52 
European Journal of Heart Failure
JANUARY 14, 2025
SGLT2-i, sodiumglucose cotransporter 2 inhibitor; T2D, type 2 diabetes. Sodiumglucose cotransporter 2 inhibitors, a class of anti-diabetic drugs, showed to improve cardiovascular functions although their mechanism of action has not yet been fully established.
40 
Stroke Journal
JANUARY 30, 2025
Patients with increasing CT-CSVD scores were older (p<0.001), more likely to have hypertension (p<0.001), diabetes (p<0.001), coronary artery disease (p=0.044), and a higher baseline systolic blood pressure (p=0.037). 1.02; score 2: OR 0.46, 95%CI 0.26-0.83; 0.83; score 3: OR 0.16, 95%CI 0.03-0.76, 1.95, p = 0.019).Conclusion:This
40 
Open Heart
DECEMBER 9, 2022
Multiple risk factors, including smoking, hyperlipiadaemia and diabetes, can have associated ED, which is correlated with cardiac events. Peripheral vascular techniques and endothelial biomarkers can be used to indirectly assess coronary ED.
Journal of Cardiovascular Pharmacology
AUGUST 18, 2022
Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. Although G protein subunit beta 4 (GNB4)-derived circular RNA (circ-GNB4; hsa_circ_0068087) is a promising candidate biomarker in diabetes mellitus, whether circ-GNB4 participates in DN occurrence and development remains unknown.
40 
Physiologically Speaking
JANUARY 12, 2024
One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. Finally, having dyslipidemia (abnormal levels of blood lipids) and diabetes were associated with a higher age acceleration. The early bird gets the worm.
124 
Heart BMJ
JANUARY 10, 2024
Growth differentiation factor (GDF)-15 has emerged as a potentially useful biomarker. Results Major determinants of GDF-15 were age, diabetes and N-terminal pro-B-type natriuretic peptide, although despite extensive phenotyping, only around half of the variability of GDF-15 could be explained (R 2 0.51).
European Journal of Heart Failure
JANUARY 10, 2025
We examined the association between CMR-estimated PCWP (CMR-PCWP) and other imaging and biomarker measures of congestion, and the effect of empagliflozin on these, in the SUGAR-DM-HF trial (NCT03485092).
Stroke Journal
FEBRUARY 1, 2024
The multivariate model (area under curve = 0.93) had three significant predictors: diabetes mellitus (aOR 36.5, Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,
40 
Journal of Cardiovascular Pharmacology
FEBRUARY 13, 2022
Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. Although G protein subunit beta 4 (GNB4)-derived circular RNA (circ-GNB4; hsa_circ_0068087) is a promising candidate biomarker in diabetes mellitus, whether circ-GNB4 participates in DN occurrence and development remains unknown.
40
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