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Shorter protective caps on chromosomes called telomeres, a proposed marker of accelerated biological cell aging, may be associated with an increased risk of stroke, dementia and late-life depression, according to an analysis of more than 356,000 people in the United Kingdom.
It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia. Knowledge gaps include initiating factors, molecular pathogenesis, relationships between arterial pathology and tissue damage, possible reversibility, pharmacological targets, and molecular biomarkers.
Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.
I am going to start with the answer to the question of whether statins cause dementia and then provide the details backing up my answer. Statins do not cause dementia. But if you are someone who thinks that statins do cause dementia and you need to see the evidence to refute that claim, then read on. The answer is: No.
Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular origins.
Stroke, Ahead of Print. Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the elderly services, and undiagnosed in the community. Neuroimaging has a major role in identifying the proportion of vascular versus other likely pathologies in patients with cognitive impairment.
I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process. Dementia is a leading cause of death and a major concern for most people as they age.
Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Both subjects with stroke and subjects with TIA had increased serum PDGFRβ compared to those without history of CVA (6608.4 pg/mL and 5337.0
Stroke, Ahead of Print. As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia.
That is severe obstructive sleep apnea (OSA), and with that serious interruption to sleep quality also comes a doubling in the risk of future heart disease, particularly stroke 6. 10 Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. Every hour. N Engl J Med.
BackgroundInfection and inflammation are dementia risk factors in population‐based cohorts; however, studies in stroke are scarce. Associations with acute and 6‐month global and domain‐specific cognitive impairment were analyzed using multivariable regression, adjusting for demographic/vascular factors and stroke severity.
During 2year followup, BACE1 activity was independently related to dementia conversion (odds ratio, 17.72;P=0.001) P=0.001) but not stroke in CSVD.ConclusionsPlasma BACE1 activity is moderately increased and associated with neurodegeneration and cognitive impairment risk in CSVD.
Stroke, Volume 55, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2024. Introduction:Early identification of white matter hyperintensity-related cognitive impairment (WMH-CI) through normal MRI images is of great significance for early clinical intervention to reduce the occurrence of dementia.
BACKGROUND:Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. CONCLUSIONS:Measurement of targeted protein biomarkers produced superior prediction of aggregated and disaggregated cardiovascular events. Circulation, Ahead of Print.
Stroke, Volume 56, Issue Suppl_1 , Page AWP49-AWP49, February 1, 2025. While plasma pTau217 is an established biomarker for AD, its relevance in vascular disease-enriched populations has not been extensively studied. Plasma pTau217 levels were found to be elevated in individuals with MCI and dementia.
Stroke, Volume 56, Issue Suppl_1 , Page ATP378-ATP378, February 1, 2025. Introduction:The molecular and metabolic changes that occur after acute ischemic stroke (AIS) are not fully understood. Due to its composition, MDA readily reacts with lipid membranes, making it a sensitive oxidative stress biomarker.
Stroke, Volume 55, Issue Suppl_1 , Page A70-A70, February 1, 2024. Introduction:Transient ischemic attack (TIA) patients have an increased risk of early dementia, but the mechanism is unclear. One potential mechanism is the damaging effects of microvascular disease on brain networks.
Stroke, Volume 55, Issue Suppl_1 , Page AWP255-AWP255, February 1, 2024. Introduction:The Neurofilament light chain (NfL) is a neuronal cytoplasmic protein and a reliable biomarker for assessing axonal damage in neurological diseases and traumatic brain injury. The mean concentration of NFL was 0.19±0.10
Stroke, Volume 55, Issue Suppl_1 , Page ATP39-ATP39, February 1, 2024. This is important as depression can mimic cognitive impairment, dementia and is treatable. Introduction:The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) contributes to the development of depression. years, IQR: 5.3-6.7).
Stroke, Volume 56, Issue Suppl_1 , Page AWP45-AWP45, February 1, 2025. They are key indicators of cerebral small vessel disease (CSVD) and are associated with mild cognitive impairment (MCI) and dementia. These findings suggest a role for MRI-visible PVS as an early biomarker for the identification of those at risk of MCI or dementia.
This misinformation would have resulted in many thousands of people giving up their medication and suffering heart attacks and strokes as a result. I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. With thousands dying.
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