Dr. Paddy Barrett

SEPTEMBER 13, 2024

Insulin resistance is a major risk factor for the leading causes of death, the leading one being cardiovascular disease. Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. The key is to identify risk much earlier.

Risk Factors 85

Risk Factors Heart Disease Dementia Diabetes 85

Hypertension Journal

SEPTEMBER 21, 2023

Recently, some randomized trials, including the SPRINT (Systolic Blood Pressure Intervention Trial), have suggested that improvements in cardiovascular risk factors may also slow cognitive decline and reduce the eventual development of dementia.

Dementia 40

Dementia Cardiovascular Interventions Blood Pressure Biomarkers 40

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. Thirty-four with 3 or more confirmed risk factors underwent serial cardiac 18F-dopamine PET at 1.5-year BACKGROUND.

Risk Factors 90

Risk Factors Dementia Biomarkers Research 90

Stroke Journal

FEBRUARY 1, 2024

Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Statistical analyses were performed using Spearman’s rank correlation and Mann Whitney U test.Results:Our subjects were split based on CVA status and matched according to vascular risk factors. pg/mL and 5337.0

Stroke 40

Stroke Strokes Dementia Biomarkers 40

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundInfection and inflammation are dementia risk factors in population‐based cohorts; however, studies in stroke are scarce. Journal of the American Heart Association, Ahead of Print. Infection may present a tractable target for reducing poststroke cognitive impairment.

Biomarkers 40

Biomarkers Dementia Stroke Strokes 40

Dr. Paddy Barrett

AUGUST 22, 2023

Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia, late-onset dementia. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. What to do?

Cholesterol 52

Cholesterol Dementia Cardiovascular Disease Coronary Artery Disease 52

Stroke Journal

FEBRUARY 1, 2024

Introduction:The Neurofilament light chain (NfL) is a neuronal cytoplasmic protein and a reliable biomarker for assessing axonal damage in neurological diseases and traumatic brain injury. Asymptomatic intracranial large artery stenosis (ILAS) has been associated with higher risk of stroke and dementia.

Stenosis 40

Stenosis Dementia Hypertension Biomarkers 40