Hypertension Journal

NOVEMBER 29, 2023

Hypertension, Ahead of Print. Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations.

Dementia 64

Dementia Hypertension Pharmacology Biomarkers 64

Hypertension Journal

SEPTEMBER 21, 2023

Hypertension, Ahead of Print. Recently, some randomized trials, including the SPRINT (Systolic Blood Pressure Intervention Trial), have suggested that improvements in cardiovascular risk factors may also slow cognitive decline and reduce the eventual development of dementia.

Dementia 40

Dementia Cardiovascular Interventions Blood Pressure Physiology 40

Journal of the American Heart Association

DECEMBER 14, 2024

We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.Methods and ResultsWe enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer'sdisease as controls.

Dementia 40

Dementia Biomarkers Hemorrhage Hypertension 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:The Neurofilament light chain (NfL) is a neuronal cytoplasmic protein and a reliable biomarker for assessing axonal damage in neurological diseases and traumatic brain injury. Asymptomatic intracranial large artery stenosis (ILAS) has been associated with higher risk of stroke and dementia.

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Stenosis Dementia Hypertension Biomarkers 40

Stroke Journal

JANUARY 30, 2025

They are key indicators of cerebral small vessel disease (CSVD) and are associated with mild cognitive impairment (MCI) and dementia. Multiple linear regression models tested associations between PVS burden and each NP test, adjusting for age, sex, smoking, diabetes, hypertension, and education.Results:Among 3777 participants (mean age 60.6

Dementia 40

Dementia Biomarkers Education Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

This is important as depression can mimic cognitive impairment, dementia and is treatable. Multivariable logistic regression models were used to relate the MRI-multi-marker CSVD score and incident depression in a primary analysis and individual CSVD biomarkers and depression in an exploratory analysis. years, IQR: 5.3-6.7).

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Dementia Biomarkers Hypertension Stroke 40

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Written by Magnus Nossen, edits by Smith The patient in today's case is an 85-year-old male with a history of COPD and dementia. Due to very severe dementia, it was impossible to obtain a detailed history. He presented to the emergency department for evaluation. Lets us consider two different clinical presentations.

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Chest Pain Pericarditis Myocardial Infarction Dementia 89