Stroke Journal

JANUARY 18, 2024

Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.

Dementia 90

Dementia Cerebrovascular Disease Biomarkers Stroke 90

Stroke Journal

MARCH 6, 2024

Vascular disease is said to be the second most common cause of dementia after Alzheimer disease, yet vascular dysfunction is now known to predate cognitive decline in Alzheimer disease, and most dementias at older ages are mixed.

Biomarkers 40

Biomarkers Dementia Stroke Strokes 40

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. BACKGROUND.

Risk Factors 96

Risk Factors Dementia Biomarkers Research 96

Stroke Journal

NOVEMBER 15, 2024

As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Stroke, Ahead of Print.

Dementia 40

Dementia Risk Factors Biomarkers Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. These data demonstrate the utility of a serum-based biomarker of BBB integrity, a powerful tool in studying the role of the BBB in various neurodegenerative diseases including Alzheimer’s dementia.

Stroke 40

Stroke Strokes Dementia Biomarkers 40

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundInfection and inflammation are dementia risk factors in population‐based cohorts; however, studies in stroke are scarce. Journal of the American Heart Association, Ahead of Print. Infection may present a tractable target for reducing poststroke cognitive impairment.

Biomarkers 40

Biomarkers Dementia Stroke Strokes 40

Dr. Paddy Barrett

AUGUST 22, 2023

Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia, late-onset dementia. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. What to do?

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Journal of the American Heart Association

DECEMBER 14, 2024

During 2year followup, BACE1 activity was independently related to dementia conversion (odds ratio, 17.72;P=0.001) It indicates that BACE1 is a promising biomarker especially for CSVDrelated neurodegeneration.

Dementia 40

Dementia Biomarkers Hemorrhage Hypertension 40

Journal of the American Heart Association

DECEMBER 1, 2023

BackgroundBrain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023.

Cerebrovascular Disease 40

Cerebrovascular Disease Dementia Biomarkers Risk Factors 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Early identification of white matter hyperintensity-related cognitive impairment (WMH-CI) through normal MRI images is of great significance for early clinical intervention to reduce the occurrence of dementia.

Dementia 40

Dementia Biomarkers Hospital Stroke 40

Dr. Paddy Barrett

OCTOBER 11, 2024

I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process. Dementia is a leading cause of death and a major concern for most people as they age.

Obesity 84

Obesity Cancer Dementia Coronary Artery Disease 84

Hypertension Journal

SEPTEMBER 21, 2023

Recently, some randomized trials, including the SPRINT (Systolic Blood Pressure Intervention Trial), have suggested that improvements in cardiovascular risk factors may also slow cognitive decline and reduce the eventual development of dementia.

Dementia 40

Dementia Cardiovascular Interventions Blood Pressure Physiology 40

Dr. Paddy Barrett

FEBRUARY 21, 2025

Type 2 Diabetes When it comes to the increasing the risk of major chronic diseases such as cardiovascular disease, many cancers and dementia, type 2 diabetes plays a huge role. 10 Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. N Engl J Med. 2024 Jun 8.

Obesity 81

Obesity Diabetes Cardiovascular Disease Chronic Disease 81

Circulation

NOVEMBER 14, 2024

BACKGROUND:Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. CONCLUSIONS:Measurement of targeted protein biomarkers produced superior prediction of aggregated and disaggregated cardiovascular events. Circulation, Ahead of Print.

Cardiovascular Disease 40

Cardiovascular Disease Dementia Biomarkers Myocardial Infarction 40

Stroke Journal

JANUARY 30, 2025

While plasma pTau217 is an established biomarker for AD, its relevance in vascular disease-enriched populations has not been extensively studied. Individuals were classified based on their cognitive status into cognitively normal, mild cognitive impairment (MCI), or dementia.

Dementia 40

Dementia Biomarkers Education Stroke 40

Dr. Paddy Barrett

SEPTEMBER 13, 2024

Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. The further along the line of insulin resistance you sit, the higher your risk of all the leading causes of death, including heart disease, dementia and many cancers 5.

Risk Factors 106

Risk Factors Heart Disease Dementia Diabetes 106

Stroke Journal

FEBRUARY 1, 2024

Introduction:Transient ischemic attack (TIA) patients have an increased risk of early dementia, but the mechanism is unclear. Stroke, Volume 55, Issue Suppl_1 , Page A70-A70, February 1, 2024. One potential mechanism is the damaging effects of microvascular disease on brain networks.

Biomarkers 40

Biomarkers Dementia Stroke Strokes 40

Journal of the American Heart Association

FEBRUARY 14, 2024

BackgroundTwo of the main causes for dementia are Alzheimer's disease (AD) and vascular pathology, with most patients showing mixed pathology. Journal of the American Heart Association, Ahead of Print. Higher NfL (b=−5.63, [95% CI, −8.95 1.78],P=0.039). Higher GFAP levels were associated with cortical infarcts (OR, 1.45 [95% CI, 1.09–1.92],P=0.010).ConclusionsPlasma

Biomarkers 40

Biomarkers Dementia Education Outcomes 40

Stroke Journal

JANUARY 30, 2025

They are key indicators of cerebral small vessel disease (CSVD) and are associated with mild cognitive impairment (MCI) and dementia. These findings suggest a role for MRI-visible PVS as an early biomarker for the identification of those at risk of MCI or dementia.

Dementia 40

Dementia Biomarkers Education Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:The Neurofilament light chain (NfL) is a neuronal cytoplasmic protein and a reliable biomarker for assessing axonal damage in neurological diseases and traumatic brain injury. Asymptomatic intracranial large artery stenosis (ILAS) has been associated with higher risk of stroke and dementia.

Stenosis 40

Stenosis Dementia Hypertension Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

This is important as depression can mimic cognitive impairment, dementia and is treatable. Multivariable logistic regression models were used to relate the MRI-multi-marker CSVD score and incident depression in a primary analysis and individual CSVD biomarkers and depression in an exploratory analysis. years, IQR: 5.3-6.7).

Dementia 40

Dementia Biomarkers Hypertension Stroke 40

Stroke Journal

JANUARY 30, 2025

Accumulation of oxidative stress has been shown to trigger the initiation and progression of cognitive deficits, including mild cognitive impairment (MCI) and Alzheimers Dementia (AD). Due to its composition, MDA readily reacts with lipid membranes, making it a sensitive oxidative stress biomarker.

BMI 40

BMI Biomarkers Dementia Stroke 40

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Written by Magnus Nossen, edits by Smith The patient in today's case is an 85-year-old male with a history of COPD and dementia. Due to very severe dementia, it was impossible to obtain a detailed history. He presented to the emergency department for evaluation. Lets us consider two different clinical presentations.

Chest Pain 89

Chest Pain Pericarditis Myocardial Infarction Dementia 89

Dr. Paddy Barrett

MARCH 14, 2025

A critical component of healthy ageing is the maintenance of cognitive capacity and avoidance of dementia. Muscle power may also play a role in the prevention or progression of dementia. Higher muscle power measures, such as gait (walking) speed, were associated with a 50% reduction in the risk of dementia 6. Am J Prev Med.

Dementia 114

Dementia Biomarkers Cancer Exercise 114

Dr. Malcolm Kendrick

OCTOBER 30, 2024

(2022-25) Swiss Reinsurance Company: £645K China Kadoorie Biobank (2002-ongoing) AstraZeneca: $300K Bayer AG: £300K GlaxoSmithKline: £3.6M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M Establishing Fuwai-Oxford research centre (2010-ongoing) Merck: £1.1M

Cholesterol 145

Cholesterol Article Research Diet 145